Compartment-specific expression of natural killer cell markers in renal transplantation: immune profile in acute rejection

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art_SANTOS_Compartmentspecific_expression_of_natural_killer_cell_markers_in_2016.PDF (266.61 KB)
Citações na Scopus
17
Tipo de produção
article
Data de publicação
2016
Editora
WILEY-BLACKWELL
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
CAMPOS, Erika Fernandes
CAMARA, Niels Olsen Saraiva
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
TRANSPLANT INTERNATIONAL, v.29, n.4, p.443-452, 2016
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Natural killer (NK) cells have been implicated in graft dysfunction. Here, we formulated hypothesis that distinct patterns of expression NK cells markers correlated with acute rejection in kidney transplantation. Therefore, we studied the pattern of NK cell markers CD56, CD57, and CD16 in different compartments of biopsies obtained from recipients diagnosed with acute graft rejection, with or without donor-specific antibodies (DSA). DSA-negative biopsies-from patients with acute T-cell mediated rejection (aTCMR) had an increased expression of CD56+ and CD57+ cells (P = 0.004 and P = 0.001) in the interstitial compartment in comparison with DSA-positive biopsies from patients acute antibody-mediated rejection (aABMR) with (aABMR C4d+) and without C4d deposition (aABMR C4d-). CD16+ cells was increased (P = 0.03) in the glomerular compartment in DSA-positive biopsies. We assume that CD16+ expression and antibody-dependent cellular cytotoxicity (ADCC) in microvascular injury can be associated with aABMR. IFN- release from cytoplasmic granules of NK cell could be associated with aTCMR. Our findings suggest that NK cells need to be carefully evaluated because variations in NK cell marker expression might imply the involvement of different immune system pathways in graft rejection.
Palavras-chave
acute antibody-mediated rejection, acute T-cell mediated rejection, donor-specific antibodies, natural killer cells, renal allograft pathology
URI
https://observatorio.fm.usp.br/handle/OPI/14389
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/16
Artigos e Materiais de Revistas Científicas - ODS/03