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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | GONCALVES, Flavia | - |
dc.contributor.author | MORAES, Miriam Santos de | - |
dc.contributor.author | FERREIRA, Lorraine Braga | - |
dc.contributor.author | CARREIRA, Ana Claudia Oliveira | - |
dc.contributor.author | KOSSUGUE, Patricia Mayumi | - |
dc.contributor.author | BOARO, Leticia Cristina Cidreira | - |
dc.contributor.author | BENTINI, Ricardo | - |
dc.contributor.author | GARCIA, Celia Regina da Silva | - |
dc.contributor.author | SOGAYAR, Mari Cleide | - |
dc.contributor.author | ARANA-CHAVEZ, Victor Elias | - |
dc.contributor.author | CATALANI, Luiz Henrique | - |
dc.date.accessioned | 2016-07-18T12:24:15Z | - |
dc.date.available | 2016-07-18T12:24:15Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | PLOS ONE, v.11, n.3, article ID e0152412, 21p, 2016 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/14424 | - |
dc.description.abstract | Regeneration of periodontal tissues requires a concerted effort to obtain consistent and predictable results in vivo. The aim of the present study was to test a new family of bioactive polymeric membranes in combination with stem cell therapy for periodontal regeneration. In particular, the novel polyester poly(isosorbide succinate-co-L-lactide) (PisPLLA) was compared with poly(L-lactide) (PLLA). Both polymers were combined with collagen (COL), hydroxyapatite (HA) and the growth factor bone morphogenetic protein-7 (BMP7), and their osteoinductive capacity was evaluated via in vitro and in vivo experiments. Membranes composed of PLLA/COL/HA or PisPLLA/COL/HA were able to promote periodontal regeneration and new bone formation in fenestration defects in rat jaws. According to quantitative real-time polymerase chain reaction (qRT-PCR) and Alizarin Red assays, better osteoconductive capacity and increased extracellular mineralization were observed for PLLA/COL/HA, whereas better osteoinductive properties were associated with PisPLLA/COL/HA. We concluded that membranes composed of either PisPLLA/COL/HA or PLLA/COL/HA present promising results in vitro as well as in vivo and that these materials could be potentially applied in periodontal regeneration. | - |
dc.description.sponsorship | CNPq | - |
dc.description.sponsorship | FAPESP [2010/17698-2, 2011/21442-6, 2011/51295-5] | - |
dc.description.sponsorship | BNDES | - |
dc.description.sponsorship | FAPESP | - |
dc.description.sponsorship | FINEP | - |
dc.description.sponsorship | MCTI | - |
dc.description.sponsorship | MS-DECIT | - |
dc.language.iso | eng | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.relation.ispartof | Plos One | - |
dc.rights | openAccess | - |
dc.subject.other | guided tissue regeneration | - |
dc.subject.other | bone morphogenetic protein-7 | - |
dc.subject.other | osteoblastic differentiation | - |
dc.subject.other | mechanical-properties | - |
dc.subject.other | barrier membranes | - |
dc.subject.other | gene-expression | - |
dc.subject.other | growth-factor | - |
dc.subject.other | defects | - |
dc.subject.other | scaffolds | - |
dc.subject.other | composite | - |
dc.title | Combination of Bioactive Polymeric Membranes and Stem Cells for Periodontal Regeneration: In Vitro and In Vivo Analyses | - |
dc.type | article | - |
dc.rights.holder | Copyright PUBLIC LIBRARY SCIENCE | - |
dc.identifier.doi | 10.1371/journal.pone.0152412 | - |
dc.identifier.pmid | 27031990 | - |
dc.subject.wos | Multidisciplinary Sciences | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | GONCALVES, Flavia:Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo, SP, Brazil | - |
hcfmusp.author.external | MORAES, Miriam Santos de:Univ Sao Paulo, Inst Biociencias, Dept Fisiol, BR-05508090 Sao Paulo, SP, Brazil | - |
hcfmusp.author.external | FERREIRA, Lorraine Braga:Univ Sao Paulo, Fac Odontol, Dept Biomat & Biol Oral, BR-05508000 Sao Paulo, SP, Brazil | - |
hcfmusp.author.external | KOSSUGUE, Patricia Mayumi:Univ Sao Paulo, Fac Med, NUCEL NETCEM Nucleo Terapia Celular & Mol, BR-05360130 Sao Paulo, SP, Brazil | - |
hcfmusp.author.external | BOARO, Leticia Cristina Cidreira:Univ Sao Paulo, Fac Odontol, Dept Biomat & Biol Oral, BR-05508000 Sao Paulo, SP, Brazil | - |
hcfmusp.author.external | BENTINI, Ricardo:Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo, SP, Brazil | - |
hcfmusp.author.external | GARCIA, Celia Regina da Silva:Univ Sao Paulo, Inst Biociencias, Dept Fisiol, BR-05508090 Sao Paulo, SP, Brazil | - |
hcfmusp.author.external | SOGAYAR, Mari Cleide:Univ Sao Paulo, Fac Med, NUCEL NETCEM Nucleo Terapia Celular & Mol, BR-05360130 Sao Paulo, SP, Brazil; Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-05508000 Sao Paulo, SP, Brazil | - |
hcfmusp.author.external | ARANA-CHAVEZ, Victor Elias:Univ Sao Paulo, Fac Odontol, Dept Biomat & Biol Oral, BR-05508000 Sao Paulo, SP, Brazil | - |
hcfmusp.author.external | CATALANI, Luiz Henrique:Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo, SP, Brazil | - |
hcfmusp.description.articlenumber | e0152412 | - |
hcfmusp.description.issue | 3 | - |
hcfmusp.description.volume | 11 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000373121800070 | - |
hcfmusp.origem.id | 2-s2.0-84977658201 | - |
hcfmusp.publisher.city | SAN FRANCISCO | - |
hcfmusp.publisher.country | USA | - |
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dc.description.index | MEDLINE | - |
hcfmusp.citation.scopus | 18 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/Outros |
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