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https://observatorio.fm.usp.br/handle/OPI/14455
Title: | Pharmacologic injection treatment of comitant strabismus |
Authors: | DEBERT, Iara; MILLER, Joel M.; DANH, Kenneth K.; SCOTT, Alan B. |
Citation: | JOURNAL OF AAPOS, v.20, n.2, p.106-111, 2016 |
Abstract: | PURPOSE To report the magnitude and stability of corrections in comitant horizontal strabismus achieved by injecting bupivacaine (BPX, optionally with epinephrine) and botulinum A toxin (BTXA) into extraocular muscles of alert adult subjects with electromyographic (EMG) guidance. METHODS A total of 55 adults with comitant horizontal strabismus participated in a prospective observational clinical series. Of these, 29 previously had undergone 1 or more unsuccessful strabismus surgeries; 4 had undergone other orbital surgeries. Thirty-one patients with esodeviations received BPX injections in a lateral rectus muscle, some with BTXA in the medial rectus; 24 patients with exodeviations received BPX in a medial rectus muscle, some with BTXA in the lateral rectus muscle. A second treatment (BPX, BTXA, or both) was administered to 27 patients who had residual strabismus after the first treatment. Five patients required additional injections. Clinical alignment was measured at 6 months and yearly thereafter through 5 years' follow-up, with mean follow-up of 28 months. A successful outcome was defined as residual deviation <= 10(Delta). RESULTS On average, presenting misalignment of 23.8(Delta) (13.4 degrees) was reduced at 28 months by 16.0(Delta) (9.1 degrees), with successful outcomes in 56% of patients. Of patients with initial misalignments <= 25(Delta), 66% had successful outcomes, with corrections averaging 13.2(Delta) (7.5 degrees); of patients with larger misalignments, 40% had successful outcomes, with corrections averaging 20.9(Delta) (11.8 degrees). Corrected alignments were stable over follow-ups as long as 5 years. CONCLUSIONS Injection treatments resulted in stable, clinically significant corrections in comitant horizontal strabismus. Injection provides a low-cost alternative to incisional strabismus surgery, particularly where it is desirable to minimize surgical anesthesia and avoid extraocular scarring. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/33 |
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