Role of low-level laser therapy on the cardiac remodeling after myocardial infarction: A systematic review of experimental studies

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Citações na Scopus
7
Tipo de produção
article
Data de publicação
2016
Título da Revista
ISSN da Revista
Título do Volume
Editora
PERGAMON-ELSEVIER SCIENCE LTD
Autores
CARLOS, Fernando Pereira
GRADINETTI, Vanessa
MANCHINI, Martha
CARVALHO, Paulo de Tarso Camillo de
SILVA JR., Jose Antonio
LEAL-JUNIOR, Ernesto Cesar Pinto
BOCALINI, Danilo Sales
VIEIRA, Stella
ANTONIO, Ednei Luiz
Citação
LIFE SCIENCES, v.151, p.109-114, 2016
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Aims: We systematically reviewed the role of low-level laser therapy (LLLT) in cardiac remodeling after myocardial infarction. Main methods: Literatures were systematically searched in several electronic databases. We included only studies with a well-standardized coronary occlusion model in vivo LLLT application. Key findings: After screening, 14 studies were eligible for review. The study heterogeneity was described in terms of rationality, gender, irradiation parameters, treatment numbers and moment of LLLT application. Three studies showed a null role of LLLT on infarct size, and only one study found positive LLLT effects on the cardiac performance. The cardioprotective role of LLLT was mediated by anti-inflammatory, pro-angiogenic and anti-oxidant actions. Significance: The reduction in infarct size is a major finding. The LLLT cardioprotection may be mediated by several molecular and cellular mechanisms. Although these results are exciting, there are many limitations that must be resolved before LLLT clinical trials.
Palavras-chave
Cardiac remodeling, Laser therapy, Myocardial infarction
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