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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | ROCHA, Luiza F. | - |
dc.contributor.author | ASSAD, Ana Paula Luppino | - |
dc.contributor.author | MARANGONI, Roberta G. | - |
dc.contributor.author | RIO, Ana Paula Toledo Del | - |
dc.contributor.author | MARQUES-NETO, Joao Francisco | - |
dc.contributor.author | SAMPAIO-BARROS, Percival D. | - |
dc.date.accessioned | 2016-07-18T12:43:44Z | - |
dc.date.available | 2016-07-18T12:43:44Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | RHEUMATOLOGY INTERNATIONAL, v.36, n.5, p.697-702, 2016 | - |
dc.identifier.issn | 0172-8172 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/14563 | - |
dc.description.abstract | The objective of this study is to describe the characteristics of patients with Erasmus syndrome (ES) in a large SSc Brazilian cohort. Nine hundred and forty-seven SSc patients attended at the Scleroderma Outpatient Clinic at two academic medical centers in Brazil and classified as SSc according to the ACR/EULAR criteria were retrospectively studied. Information on demographics, clinical, and laboratory features was obtained by chart review. ES patients had their HLA class II characterized by PCR-SSO method as available. Among the 947 SSc patients studied, nine (0.9 %) had ES. These ES patients were predominantly male (78 %) and smokers (68 %) and presented diffuse SSc (67 %). Mean time of occupational exposure to silica was 13.7 years, with mean age at onset of 47 years. Previous history of tuberculosis was referred by 33 % of the ES patients. All the ES patients presented Raynaud's phenomenon, esophageal involvement, and interstitial lung disease (ILD). Antinuclear antibodies were present in all the ES patients, while anti-topoisomerase I was positive in 44 % and no patient had anticentromere antibody. Three different HLA-DQB alleles (0506, 0305, and 0303) were observed. Compared to non-ES cases, patients with ES were associated with male gender (p < 0.001), diffuse SSc (p < 0.05), ILD (p < 0.05), positive anti-topoisomerase I antibodies (p < 0.05), and death (p < 0.05). Multivariate analysis did not confirm that silicosis is an independent risk factor for SSc. To conclude, ES was rare in this large SSc cohort, although associated with a bad prognosis. | - |
dc.description.sponsorship | Federico Foundation, Switzerland | - |
dc.language.iso | eng | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.relation.ispartof | Rheumatology International | - |
dc.rights | restrictedAccess | - |
dc.subject | Systemic sclerosis | - |
dc.subject | Silicosis | - |
dc.subject | Erasmus syndrome | - |
dc.subject | Occupational exposure | - |
dc.subject.other | connective-tissue disease | - |
dc.subject.other | occupational risk-factors | - |
dc.subject.other | scleroderma | - |
dc.subject.other | markers | - |
dc.subject.other | workers | - |
dc.title | Systemic sclerosis and silica exposure: a rare association in a large Brazilian cohort | - |
dc.type | article | - |
dc.rights.holder | Copyright SPRINGER HEIDELBERG | - |
dc.identifier.doi | 10.1007/s00296-015-3412-0 | - |
dc.identifier.pmid | 26759224 | - |
dc.subject.wos | Rheumatology | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | ROCHA, Luiza F.:Lusiada Fdn Sch Med, Santos, Brazil | - |
hcfmusp.author.external | MARANGONI, Roberta G.:Northwestern Univ, Div Rheumatol, Chicago, IL 60611 USA | - |
hcfmusp.author.external | RIO, Ana Paula Toledo Del:Univ Estadual Campinas, Rheumatol Unit, Campinas, Brazil | - |
hcfmusp.author.external | MARQUES-NETO, Joao Francisco:Univ Estadual Campinas, Rheumatol Unit, Campinas, Brazil | - |
hcfmusp.description.beginpage | 697 | - |
hcfmusp.description.endpage | 702 | - |
hcfmusp.description.issue | 5 | - |
hcfmusp.description.volume | 36 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84954315497 | - |
hcfmusp.origem.id | WOS:000374567500011 | - |
hcfmusp.publisher.city | HEIDELBERG | - |
hcfmusp.publisher.country | GERMANY | - |
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dc.description.index | MEDLINE | - |
dc.identifier.eissn | 1437-160X | - |
hcfmusp.citation.scopus | 17 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/Outros Artigos e Materiais de Revistas Científicas - LIM/17 Artigos e Materiais de Revistas Científicas - ODS/03 |
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