Capgras syndrome associated with limbic encephalitis in a patient with diffuse large B-cell lymphoma

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author SOARES NETO, Herval Ribeiro FMUSP-HC
CAVALCANTE, Wagner Cid Palmeira FMUSP-HC
MARTINS FILHO, Sebastião Nunes FMUSP-HC
SMID, Jerusa FMUSP-HC
NITRINI, Ricardo FMUSP-HC
dc.date.issued 2016
dc.identifier.citation DEMENTIA & NEUROPSYCHOLOGIA, v.10, n.1, p.63-69, 2016
dc.identifier.issn 1980-5764
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/14674
dc.description.abstract We report the case of a patient with insidious onset and slowly progressive cognitive impairment, behavioral symptoms, temporal lobe seizures and delusional thoughts typical of delusional misidentification syndromes. Clinical presentation along with extensive diagnostic work-up revealed limbic encephalitis secondary to diffuse large B-cell lymphoma. The patient underwent immunotherapy with high-dose corticosteroid but no significant improvement was observed. No specific treatment for lymphoma was performed because the patient died of septic shock following a nosocomial respiratory infection. Delusional misidentification syndromes are an unusual and unique form of cognitive impairment in which a patient consistently misidentifies persons, places, objects, or events. Capgras syndrome is the most common subtype of this disorder, being defined by the recurrent and transient belief that someone close has been substituted by an imposter. These entities are generally associated with neurodegenerative diseases and psychiatric disturbances. Rare reports of associations between misidentification syndromes and autoimmune diseases such as multiple sclerosis have been published, but no papers address a correlation with limbic encephalitis or lymphoma.
dc.description.abstract Nós relatamos o caso de um paciente com início insidioso e lentamente progressivo de declínio cognitivo, sintomas comportamentais, crises convulsivas do lobo temporal e pensamentos delirantes típicos dos delírios monotemáticos de identificação. A apresentação clínica associada aos exames complementares levaram ao diagnóstico de encefalite límbica relacionada a linfoma difuso de grandes células B. O paciente foi submetido a imunoterapia com altas doses de corticoide sem melhora clínica. Não foi realizado tratamento específico para o linfoma em função do paciente ter evoluído para óbito por choque séptico secundário a infecção respiratória nosocomial. Os delírios monotemáticos de identificação representam uma forma única e incomum de comprometimento cognitivo nas quais o paciente consistentemente identifica de forma errônea pessoas, lugares, objetos ou eventos. A síndrome de Capgras é o subtipo mais comum dessas desordens, sendo definida como a crença recorrente e transitória que um impostor substituiu uma pessoa familiar. Essas entidades são geralmente relacionadas com doenças neurodegenerativas e distúrbios psiquiátricos. Raros relatos da associação entre os delírios monotemáticos de identificação e doenças autoimunes como esclerose múltipla foram publicados, porém não há artigos abordando a correlação com encefalite límbica ou linfoma.
dc.language.iso eng
dc.publisher Associação de Neurologia Cognitiva e do Comportamento
dc.relation.ispartof Dementia & Neuropsychologia
dc.rights openAccess
dc.subject Capgras syndrome; limbic encephalitis; lymphoma; síndrome de Capgras; encefalite límbica; linfoma
dc.title Capgras syndrome associated with limbic encephalitis in a patient with diffuse large B-cell lymphoma
dc.title.alternative Síndrome de Capgras associada a Encefalite Límbica em um Paciente com Linfoma Difuso de Grandes Células B
dc.type article
dc.rights.holder Copyright Associação de Neurologia Cognitiva e do Comportamento
dc.description.group LIM/15
dc.identifier.doi 10.1590/S1980-57642016DN10100012
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author SOARES NETO, Herval Ribeiro:HC:ICHC
hcfmusp.author CAVALCANTE, Wagner Cid Palmeira:HC:ICHC
hcfmusp.author MARTINS FILHO, Sebastião Nunes:HC:ICHC
hcfmusp.author SMID, Jerusa:HC:ICHC
hcfmusp.author NITRINI, Ricardo:FM:MNE
hcfmusp.origem.id 2-s2.0-84961822663
hcfmusp.origem.id SCIELO:S1980-57642016000100063
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