High levels of C-reactive protein are associated with reduced vagal modulation and low physical activity in young adults

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art_NEGRAO_High_levels_of_C_reactive_protein_are_associated_2012.PDF (237.77 KB)
Citações na Scopus
15
Tipo de produção
article
Data de publicação
2012
Editora
WILEY-BLACKWELL
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
SOARES-MIRANDA, L.
SILVA, P.
SANTOS, R.
VALE, S.
MOTA, J.
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, v.22, n.2, p.278-284, 2012
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The purpose of this study was to examine the relationship between cardiac autonomic control derived from heart rate variability (HRV), high-sensitivity C-reactive protein (hs-CRP) and physical activity (PA) levels measured using accelerometers. A total of 80 healthy university students volunteered to participate in this study (20.56 +/- 0.82 years, 1.36 +/- 1.5 mg/L of hs-CRP). The participants were divided into groups based on tertiles of hs-CRP. Analysis of covariance adjusted to PA was used to assess group differences in HRV. Associations between hs-CRP, HRV indices and PA were analyzed using Pearson's correlation. The participants at the highest tertile of hs-CRP (tertile 3) had lower cardiac vagal modulation (SDNN, tertile 1=78.05 +/- 5.9,tertile 2=82.43 +/- 5.9,tertile 3=56.03 +/- 6.1; SD1, tertile 1=61.27 +/- 5.3, tertile 2=62.93 +/- 5.4, tertile 3=40.03 +/- 5.5). In addition, vagal indices were inversely correlated with hs-CRP but positively correlated with PA (SDNN r=-0.320, SD1 r=-0.377; SDNN r=0.304, SD1 r=0.299; P<0.05). Furthermore, the most physically active subjects had lower levels of hs-CRP and the highest levels of vagal modulation.
Palavras-chave
physical activity, accelerometer, young adults
URI
https://observatorio.fm.usp.br/handle/OPI/1516
Referências
  1. Allison MA, 2007, ATHEROSCLEROSIS, V194, pE87, DOI 10.1016/j.atherosclerosis.2006.10.006
  2. Araujo F, 2006, INT J CARDIOL, V107, P333, DOI 10.1016/j.ijcard.2005.03.044
  3. Bernik TR, 2002, J EXP MED, V195, P781, DOI 10.1084/jem.20011714
  4. Biro G, 2002, EUR J CLIN NUTR, V56, pS25, DOI 10.1038/sj/ejcn/1601426
  5. Brage S, 2003, MED SCI SPORT EXER, V35, P1447, DOI 10.1249/01.MSS.0000079078.62035.EC
  6. Braun C, 1998, AM J PHYSIOL-HEART C, V275, pH1577
  7. Brouwer J, 1996, J AM COLL CARDIOL, V28, P1183, DOI 10.1016/S0735-1097(96)00279-3
  8. Danesh J, 2004, NEW ENGL J MED, V350, P1387, DOI 10.1056/NEJMoa032804
  9. Esliger D., 2005, J PHYS ACT HEALTH, V3, P366
  10. Freedson PS, 1998, MED SCI SPORT EXER, V30, P777, DOI 10.1097/00005768-199805000-00021
  11. Gilder M, 2008, J SPORT SCI, V26, P781, DOI 10.1080/02640410701836895
  12. Graham I, 2007, EUR J CARDIOV PREV R, V14, pS1, DOI 10.1097/01.hjr.0000277983.23934.c9
  13. Jae SY, 2009, MOL MED, V15, P291, DOI 10.2119/molmed.2009.00057
  14. Koenig W, 1999, CIRCULATION, V99, P237
  15. Lampert R, 2008, AM HEART J, V156, pe751
  16. La Rovere MT, 2003, CIRCULATION, V107, P565, DOI 10.1161/01.CIR.0000047275.25795.17
  17. Libby P, 2006, AM J CLIN NUTR, V83, p456S
  18. Madsen T, 2007, ANN NONINVAS ELECTRO, V12, P216, DOI 10.1111/j.1542-474X.2007.00164.x
  19. Milani RV, 2004, J AM COLL CARDIOL, V43, P1056, DOI 10.1016/j.jacc.2003.10.041
  20. Mourot L, 2004, CLIN PHYSIOL FUNCT I, V24, P10, DOI 10.1046/j.1475-0961.2003.00523.x
  21. Nunan D, 2009, MED SCI SPORT EXER, V41, P243, DOI 10.1249/MSS.0b013e318184a4b1
  22. Panagiotakos DB, 2005, PREV MED, V40, P432, DOI 10.1016/j.ypmed.2004.07.010
  23. Pasceri V, 2000, CIRCULATION, V102, P2165
  24. Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
  25. Radespiel-Troger M, 2003, CLIN AUTON RES, V13, P99, DOI 10.1007/s10286-003-0085-7
  26. Rennie KL, 2003, AM J EPIDEMIOL, V158, P135, DOI 10.1093/aje/kwg120
  27. Ridker PM, 1997, NEW ENGL J MED, V336, P973, DOI 10.1056/NEJM199704033361401
  28. Ridker PM, 2001, JAMA-J AM MED ASSOC, V285, P2481, DOI 10.1001/jama.285.19.2481
  29. Rothney MP, 2008, OBESITY, V16, P1946, DOI 10.1038/oby.2008.279
  30. Sajadieh A, 2004, EUR HEART J, V25, P363, DOI 10.1016/j.ehj.2003.12.003
  31. Shemesh T, 2006, CLIN CHIM ACTA, V367, P69, DOI 10.1016/j.cca.2005.11.014
  32. Sloan RP, 2007, MOL MED, V13, P178, DOI 10.2119/2006-00112.Sloan
  33. Soares-Miranda L, 2009, EUR J CARDIOV PREV R, V16, P705, DOI 10.1097/HJR.0b013e3283316cd1
  34. Stein PK, 2008, J AM GERIATR SOC, V56, P315, DOI 10.1111/j.1532-5415.2007.01564.x
  35. Stewart LK, 2007, MED SCI SPORT EXER, V39, P1714, DOI 10.1249/mss.0b013e31811ece1c
  36. Task Force of the European Society of Cardiology and the North American Society of Pacing Electrophysiology, 1996, CIRCULATION, V93, P1043
  37. Thayer JF, 2009, J INTERN MED, V265, P439, DOI 10.1111/j.1365-2796.2008.02023.x
  38. Tracey KJ, 2007, J CLIN INVEST, V117, P289, DOI 10.1172/JCI30555
  39. TSUJI H, 1994, CIRCULATION, V90, P878
  40. Ulloa L, 2005, NAT REV DRUG DISCOV, V4, P673, DOI 10.1038/nrd1797
  41. Viles-Gonzalez JF, 2004, EUR HEART J, V25, P1197, DOI 10.1106/j.ehj.2004.03.011
  42. Wang H, 2003, NATURE, V421, P384, DOI 10.1038/nature01339
  43. Zwaka TP, 2001, CIRCULATION, V103, P1194

Coleções
Artigos e Materiais de Revistas Científicas - HC/InCor