Cerebrospinal fluid approach on neuro-oncology

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art_GOMES_Cerebrospinal_fluid_approach_on_neurooncology_2013.PDF (127.75 KB)
Citações na Scopus
13
Tipo de produção
article
Data de publicação
2013
Editora
DOI
Indexadores
SciELO
Scopus
Web of Science
PubMed
Título da Revista
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Título do Volume
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Autor de Grupo de pesquisa
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Citação
ARQUIVOS DE NEURO-PSIQUIATRIA, v.71, n.9B, p.677-680, 2013
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Central nervous system (CNS) involvement is a major complication of haematological and solid tumors with an incidence that ranges from 10% in solid malignances up to 25% in specific leukaemia or lymphoma subtypes. Cerebrospinal fluid (CSF) patterns are unspecific. Though CSF cytology has a high specificity (up to 95%), its sensitivity is generally less than 50% and no diagnostic gold standard marker is available, yet. New technologies such as flow cytometry, molecular genetics and newer biomarkers may improve diagnostic sensitivity and specificity, leading to the CNS involvement diagnosis, and consequently, to an effective prophylaxis and successful treatment.
Palavras-chave
cerebrospinal fluid, biomarkers, leptomeningeal metastasis, neoplastic meningitis
URI
https://observatorio.fm.usp.br/handle/OPI/16004
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Coleções
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - LIM/15
Artigos e Materiais de Revistas Científicas - ODS/03