Sevoflurane preconditioning during myocardial ischemia-reperfusion reduces infarct size and preserves autonomic control of circulation in rats

Imagem de Miniatura
Arquivos
art_PASQUALIN_Sevoflurane_preconditioning_during_myocardial_ischemiareperfusion_reduces_infarct_size_2016.PDF (393.29 KB)
Citações na Scopus
17
Tipo de produção
article
Data de publicação
2016
Editora
ACTA CIRURGICA BRASILEIRA
DOI
Indexadores
SciELO
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
PASQUALIN, Rubens Campana
SOUZA, Leandro Ezequiel de
SIRVENTE, Raquel
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
ACTA CIRURGICA BRASILEIRA, v.31, n.5, p.338-345, 2016
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
PURPOSE: To investigate the myocardial ischemia-reperfusion with sevoflurane anesthetic preconditioning (APC) would present beneficial effects on autonomic and cardiac function indexes after the acute phase of a myocardial ischemia-reperfusion. METHODS: Twenty Wistar rats were allocated in three groups: control (CON, n=10), myocardial infarction with sevoflurane (SEV, n=5) and infarcted without sevoflurane (INF, n=5). Myocardial ischemia (60 min) and reperfusion were performed by temporary coronary occlusion. Twenty-one days later, the systolic and diastolic function were evaluated by echocardiography; spectral analysis of the systolic arterial pressure (SAPV) and heart rate variability (HRV) were assessed. After the recording period, the infarct size (IS) was evaluated. RESULTS: The INF group presented greater cardiac dysfunction and increased sympathetic modulation of the SAPV, as well as decreased alpha index and worse vagal modulation of the HRV. The SEV group exhibited attenuation of the systolic and diastolic dysfunction and preserved vagal modulation (square root of the mean squared differences of successive R-R intervals and high frequency) of HRV, as well as a smaller IS. CONCLUSION: Sevoflurane preconditioning better preserved the cardiac function and autonomic modulation of the heart in post-acute myocardial infarction period.
Palavras-chave
Autonomic Nervous System, Heart Rate, Myocardial Infarction, Ischemic Preconditioning, Myocardial, Rats
URI
https://observatorio.fm.usp.br/handle/OPI/16053
Referências
  1. Bignami E, 2013, J CARDIOTHOR VASC AN, V27, P50, DOI 10.1053/j.jvca.2012.06.007
  2. Buccelletti F, 2009, EUR REV MED PHARMACO, V13, P299
  3. Cai JR, 2014, J THORAC CARDIOV SUR, V148, P3127, DOI 10.1016/j.jtcvs.2014.07.085
  4. Camm AJ, 1996, CIRCULATION, V93, P1043
  5. Communal C, 1998, CIRCULATION, V98, P1329
  6. da Luz VF, 2015, CLIN EXP PHARMACOL P, V42, P1098, DOI 10.1111/1440-1681.12456
  7. FISHBEIN MC, 1981, AM HEART J, V101, P593, DOI 10.1016/0002-8703(81)90226-X
  8. FLORAS JS, 1988, J HYPERTENS, V6, P525, DOI 10.1097/00004872-198807000-00003
  9. Florea VG, 2014, CIRC RES, V114, P1815, DOI 10.1161/CIRCRESAHA.114.302589
  10. FREEDMAN BM, 1985, ANESTHESIOLOGY, V62, P29, DOI 10.1097/00000542-198501000-00006
  11. Furlan R, 2000, CIRCULATION, V101, P886
  12. Harthmann AD, 2007, AUTON NEUROSCI-BASIC, V133, P115, DOI 10.1016/j.autneu.2006.10.004
  13. Kashimoto S, 1997, EUR J ANAESTH, V14, P359, DOI 10.1046/j.1365-2346.1997.00092.x
  14. KLEIGER RE, 1987, AM J CARDIOL, V59, P256, DOI 10.1016/0002-9149(87)90795-8
  15. La Rovere MT, 1998, LANCET, V351, P478
  16. MALIK M, 1989, MED BIOL ENG COMPUT, V27, P603, DOI 10.1007/BF02441642
  17. Martelli D, 2014, AM J PHYSIOL-HEART C, V307, pH1005, DOI 10.1152/ajpheart.00361.2014
  18. Mostarda C, 2010, CLIN EXP PHARMACOL P, V37, P447, DOI 10.1111/j.1440-1681.2009.05327.x
  19. ODEMUYIWA O, 1991, AM J CARDIOL, V68, P434, DOI 10.1016/0002-9149(91)90774-F
  20. PAGANI M, 1986, CIRC RES, V59, P178
  21. Pagani M, 1997, CIRCULATION, V95, P1441
  22. Palacios M, 2007, PHYSIOL MEAS, V28, P677, DOI 10.1088/0967-3334/28/6/006
  23. SPADARO J, 1980, ARCH PATHOL LAB MED, V104, P179
  24. Spencer FA, 2002, CIRCULATION, V105, P2605, DOI 10.1161/01.CIR.0000017861.00991.2F
  25. Stauss HM, 2007, CLIN EXP PHARMACOL P, V34, P362, DOI 10.1111/j.1440-1681.2007.04588.x
  26. Toepfer Marcell, 1996, Clinical Science (London), V91, P117
  27. Toller WG, 1999, ANESTHESIOLOGY, V91, P1437, DOI 10.1097/00000542-199911000-00037
  28. Triposkiadis F, 2009, J AM COLL CARDIOL, V54, P1747, DOI 10.1016/j.jacc.2009.05.015
  29. Vaseghi M, 2008, PROG CARDIOVASC DIS, V50, P404, DOI 10.1016/j.pcad.2008.01.003
  30. Yu CH, 2006, CAN J ANAESTH, V53, P906
  31. Zamo FS, 2010, CLINICS, V65, P85, DOI 10.1590/S1807-59322010000100013

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCG
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/ICr
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/08
Artigos e Materiais de Revistas Científicas - LIM/59
Carregar mais