Breast reconstruction and risk of lymphedema after mastectomy: A prospective cohort study with 10 years of follow-up

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art_MENEZES_Breast_reconstruction_and_risk_of_lymphedema_after_mastectomy_2016.PDF (360.82 KB)
Citações na Scopus
15
Tipo de produção
article
Data de publicação
2016
Editora
ELSEVIER SCI LTD
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
MENEZES, Monique M.
BELLO, Marcelo A.
MILLEN, Eduardo
LUCAS, Frederico A. S.
CARVALHO, Flavia N.
PEREIRA, Ana Carolina P. R.
KOIFMAN, Rosalina J.
BERGMANN, Anke
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, v.69, n.9, p.1218-1226, 2016
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective: The aim of this study is to assess the incidence and risk factors for lymphedema in women submitted to mastectomy, with or without breast reconstruction. Methods: A cohort study was performed on women submitted to mastectomy with axillary lymphadenectomy in a single center. The follow-up included clinical evaluation and arm column measurements before surgery, at 30 days, 6 months, 5 years, and 10 years after surgery. For women subjected to late reconstruction, the time of occurrence of lymphedema (before or after reconstruction) was observed. Results: We followed up on 622 patients submitted to mastectomy and axillary lymphadenectomy for an average period of 57 months after surgery. In total, 94 women were submitted to breast reconstruction, 47 (8%) of them immediate and 47 (8%) late reconstructions. Incidence of lymphedema in the whole group was 33% (n = 204). Among the patients submitted to reconstruction, 28% of them developed lymphedema, on average, 93 months (CI 95%, 88-98) after surgical treatment. In women not subjected to reconstruction, 179 (34%) developed lymphedema, on average, after 106 months (CI 95%, 96-116) (p = 0.03). Breast reconstruction reduced lymphedema risk in 36% (HR = 0.64, CI 96%, 0.42-0.98, p = 0.04). After adjustment for pathological staging and radiotherapy, this was not statistically significant (HR = 0.79, CI 95%, 0.52-1.21, p = 0.28). Conclusion: Breast reconstruction does not increase the risk of lymphedema in long-term follow-up.
Palavras-chave
Breast neoplasia, Reconstruction, Incidence, Lymphedema, Risk factors
URI
https://observatorio.fm.usp.br/handle/OPI/16060
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCG
Artigos e Materiais de Revistas Científicas - LIM/02