Vitamin D deficiency contributes to vascular damage in sustained ischemic acute kidney injury
Carregando...
Citações na Scopus
39
Tipo de produção
article
Data de publicação
2016
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY-BLACKWELL
Autores
Citação
PHYSIOLOGICAL REPORTS, v.4, n.13, article ID e12829, 13p, 2016
Resumo
Reductions in renal microvasculature density and increased lymphocyte activity may play critical roles in the progression of chronic kidney disease (CKD) following acute kidney injury (AKI) induced by ischemia/reperfusion injury (IRI). Vitamin D deficiency is associated with tubulointerstitial damage and fibrosis progression following IRI-AKI. We evaluated the effect of vitamin D deficiency in sustained IRI-AKI, hypothesizing that such deficiency contributes to the early reduction in renal capillary density or alters the lymphocyte response to IRI. Wistar rats were fed vitamin D-free or standard diets for 35days. On day 28, rats were randomized into four groups: control, vitamin D deficient (VDD), bilateral IRI, and VDD+IRI. Indices of renal injury and recovery were evaluated for up to 7days following the surgical procedures. VDD rats showed reduced capillary density (by cablin staining), even in the absence of renal I/R. In comparison with VDD and IRI rats, VDD+IRI rats manifested a significant exacerbation of capillary rarefaction as well as higher urinary volume, kidney weight/body weight ratio, tissue injury scores, fibroblast-specific protein-1, and alpha-smooth muscle actin. VDD+IRI rats also had higher numbers of infiltrating activated CD4(+) and CD8(+) cells staining for interferon gamma and interleukin-17, with a significant elevation in the Th17/T-regulatory cell ratio. These data suggest that vitamin D deficiency impairs renal repair responses to I/R injury, exacerbates changes in renal capillary density, as well as promoting fibrosis and inflammation, which may contribute to the transition from AKI to CKD.
Palavras-chave
Acute kidney injury, CD4(+) lymphocytes, CD8(+) lymphocytes, cytokines, ischemia reperfusion injury, renal microvascular density, T-reg cells, vitamin D deficiency
Referências
- Ascon DB, 2008, J LEUKOCYTE BIOL, V84, P1400, DOI 10.1189/jlb.0907651
- Ascon M, 2009, KIDNEY INT, V75, P526, DOI 10.1038/ki.2008.602
- Basile DP, 2007, KIDNEY INT, V72, P151, DOI 10.1038/sj.ki.5002312
- Basile DP, 2011, AM J PHYSIOL-RENAL, V300, pF721, DOI 10.1152/ajprenal.00546.2010
- Basile David P., 2014, Cardiovascular & Hematological Disorders - Drug Targets, V14, P3
- Basile DP, 2016, J AM SOC NEPHROL, V27, P687, DOI 10.1681/ASN.2015030309
- Basile DP, 2008, AM J PHYSIOL-RENAL, V294, pF928, DOI 10.1152/ajprenal.00596.2007
- Basile DP, 2001, AM J PHYSIOL-RENAL, V281, pF887
- Belayev LY, 2014, CURR OPIN NEPHROL HY, V23, P149, DOI 10.1097/01.mnh.0000441051.36783.f3
- Braun Andrea B., 2013, Inflammation & Allergy Drug Targets, V12, P262
- Braun AB, 2012, CRIT CARE MED, V40, P3170, DOI 10.1097/CCM.0b013e318260c928
- Burne MJ, 2001, J CLIN INVEST, V108, P1283, DOI 10.1172/JCI12080
- Charron AJ, 1999, AM J PHYSIOL-HEART C, V277, pH1985
- Chawla LS, 2011, KIDNEY INT, V79, P1361, DOI 10.1038/ki.2011.42
- Chawla LS, 2012, KIDNEY INT, V82, P516, DOI 10.1038/ki.2012.208
- Choi HY, 2015, STEM CELL RES THER, V6, DOI 10.1186/s13287-015-0012-6
- Coca SG, 2012, KIDNEY INT, V81, P442, DOI 10.1038/ki.2011.379
- Day YJ, 2006, J IMMUNOL, V176, P3108
- desAraujo M., 2005, J AM SOC NEPHROL, V16, P3339
- desBoer I. H., 2011, CLIN J AM SOC NEPHRO, V6, P2141
- desBraganca A. C., 2015, PHYSL REP, V3
- Dusso AS, 2012, KIDNEY INT, V81, P937, DOI 10.1038/ki.2012.30
- Dusso AS, 2005, AM J PHYSIOL-RENAL, V289, pF8, DOI 10.1152/ajprenal.00336.2004
- Gandolfo MT, 2009, KIDNEY INT, V76, P717, DOI 10.1038/ki.2009.259
- Goncalves JG, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0107228
- Jang HR, 2009, J MOL MED-JMM, V87, P859, DOI 10.1007/s00109-009-0491-y
- Jang HR, 2009, CLIN IMMUNOL, V130, P41, DOI 10.1016/j.clim.2008.08.016
- Kienreich K, 2013, NUTRIENTS, V5, P3005, DOI 10.3390/nu5083005
- Kramann R, 2014, J AM SOC NEPHROL, V25, P1924, DOI 10.1681/ASN.2013101121
- Lancas T, 2011, RESPIRATION, V82, P177, DOI 10.1159/000326897
- Lanske B, 2007, J NUTR BIOCHEM, V18, P771, DOI 10.1016/j.jnutbio.2007.02.002
- Liang M, 2015, KIDNEY INT, V88, P490, DOI 10.1038/ki.2015.73
- Manickam N, 2014, AM J PHYSIOL-RENAL, V307, pF159, DOI 10.1152/ajprenal.00546.2013
- Megyesi J, 1996, AM J PHYSIOL-RENAL, V271, pF1211
- Mehrotra P, 2015, KIDNEY INT, V88, P776, DOI 10.1038/ki.2015.200
- Miyaji T, 2001, J AM SOC NEPHROL, V12, P900
- Moe SM, 2008, PRIMARY CARE, V35, P215, DOI 10.1016/j.pop.2008.01.007
- Molinari C, 2011, CELL PHYSIOL BIOCHEM, V27, P661, DOI 10.1159/000330075
- Patel TV, 2009, SEMIN NEPHROL, V29, P113, DOI 10.1016/j.semnephrol.2009.01.004
- Rabb H, 2000, AM J PHYSIOL-RENAL, V279, pF525
- Venkatachalam MA, 2010, AM J PHYSIOL-RENAL, V298, pF1078, DOI 10.1152/ajprenal.00017.2010
- Wu VC, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.114.000933
- Zhou LL, 2015, J AM SOC NEPHROL, V26, P677, DOI 10.1681/ASN.2013101067