Age, Gender, and Race-Based Coronary Artery Calcium Score Percentiles in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP PEREIRA, Alexandre C. FMUSP-HC
FOPPA, Murilo
BLAHA, Michael J.
LOTUFO, Paulo A. FMUSP-HC 2016
dc.identifier.citation CLINICAL CARDIOLOGY, v.39, n.6, p.352-359, 2016
dc.identifier.issn 0160-9289
dc.description.abstract Background: Coronary artery calcium (CAC) has been demonstrated to independently predict the risk of cardiovascular events and all-cause mortality, especially among White populations. Although the population distribution of CAC has been determined for several White populations, the distribution in ethnically admixed groups has not been well established. Hypothesis: The CAC distribution, stratified for age, gender and race, is similar to the previously described distribution in the MESA study. Methods: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a prospective cohort study designed to investigate subclinical cardiovascular disease in 6 different centers of Brazil. Similar to previous studies, individuals with self-reported coronary or cerebrovascular disease and those treated for diabetes mellitus were excluded from analysis. Results: Percentiles of CAC distribution were estimated with nonparametric techniques. The analysis included 3616 individuals (54% female; mean age, 50 years). As expected, CAC prevalence and burden were steadily higher with increasing age, as well as increased in men and in White individuals. Our results revealed that for a given CAC score, the ELSA-derived CAC percentile would be lower in men compared with the Multi-Ethnic Study of Atherosclerosis (MESA) and would be higher in women compared with MESA. Conclusions: In our sample of the Brazilian population, we observed significant differences in CAC by sex, age, and race. Adjusted for age and sex, low-risk individuals from the Brazilian population present with significantly lower CAC prevalence and burden compared with other low-risk individuals from other worldwide populations. Using US-derived percentiles in Brazilian individuals may lead to overestimating relative CAC burden in men and underestimating relative CAC burden in women.
dc.language.iso eng
dc.publisher WILEY-BLACKWELL
dc.relation.ispartof Clinical Cardiology
dc.rights restrictedAccess
dc.subject.other beam computed-tomography; atherosclerosis mesa; white subjects; heart-disease; risk-factors; calcification; angiography; accuracy; events; young
dc.title Age, Gender, and Race-Based Coronary Artery Calcium Score Percentiles in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
dc.type article
dc.rights.holder Copyright WILEY-BLACKWELL LIM/13 LIM/20
dc.identifier.doi 10.1002/clc.22539
dc.identifier.pmid 27082165
dc.type.category original article
dc.type.version publishedVersion PEREIRA, Alexandre C.:HC:INCOR GOMEZ, Luz M.:HC:LIM/13 BITTENCOURT, Marcio Sommer:HU:SCPACEX-62 STANIAK, Henrique Lane:HU:DVCLME-62 BENSENOR, Isabela M.:FM:MCM LOTUFO, Paulo A.:FM:MCM · SHAROVSKY, Rodolfo:Univ Sao Paulo, Ctr Clin & Epidemiol Res, Sao Paulo, Brazil
· FOPPA, Murilo:Fed Univ, Dept Cardiol, Porto Alegre, RS, Brazil
· BLAHA, Michael J.:Johns Hopkins Ciccarone Ctr Prevent Heart Dis, Baltimore, MD USA 2-s2.0-84976320783 WOS:000379924400007 HOBOKEN USA
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dc.description.index MEDLINE
dc.identifier.eissn 1932-8737
hcfmusp.citation.scopus 13
hcfmusp.citation.wos 13 Brasil Estados Unidos

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