Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/16129
Title: Myocardial Infarction-Associated Transcript, a Long Noncoding RNA, Is Overexpressed During Dilated Cardiomyopathy Due to Chronic Chagas Disease
Authors: FRADE, Amanda FarageLAUGIER, LaurieFERREIRA, Ludmila Rodrigues PintoBARON, Monique AndradeBENVENUTI, Luiz AlbertoTEIXEIRA, Priscila CamilloNAVARRO, Isabela CunhaCABANTOUS, SandrineFERREIRA, Frederico MoraesCANDIDO, Darlan da SilvaGAIOTTO, Fabio AntonioBACAL, FernandoPOMERANTZEFF, PabloSANTOS, Ronaldo Honorato BarrosKALIL, JorgeCUNHA-NETO, EdecioCHEVILLARD, Christophe
Citation: JOURNAL OF INFECTIOUS DISEASES, v.214, n.1, p.161-165, 2016
Abstract: Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of the lncRNA known as myocardial infarction-associated transcript (MIAT) has been associated with myocardial infarction. Chagas disease causes a severe inflammatory dilated chronic cardiomyopathy (CCC). We investigated the role of MIAT in CCC. A whole-transcriptome analysis of heart biopsy specimens and formalin-fixed, paraffin-embedded samples revealed that MIAT was overexpressed in patients with CCC, compared with subjects with noninflammatory dilated cardiomyopathy and controls. These results were confirmed in a mouse model. Results suggest that MIAT is a specific biomarker of CCC.
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