Myocardial Infarction-Associated Transcript, a Long Noncoding RNA, Is Overexpressed During Dilated Cardiomyopathy Due to Chronic Chagas Disease

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author FRADE, Amanda Farage FMUSP-HC
LAUGIER, Laurie
FERREIRA, Ludmila Rodrigues Pinto FMUSP-HC
BARON, Monique Andrade FMUSP-HC
BENVENUTI, Luiz Alberto FMUSP-HC
TEIXEIRA, Priscila Camillo
NAVARRO, Isabela Cunha FMUSP-HC
CABANTOUS, Sandrine
FERREIRA, Frederico Moraes FMUSP-HC
CANDIDO, Darlan da Silva FMUSP-HC
GAIOTTO, Fabio Antonio FMUSP-HC
BACAL, Fernando FMUSP-HC
POMERANTZEFF, Pablo FMUSP-HC
SANTOS, Ronaldo Honorato Barros FMUSP-HC
KALIL, Jorge FMUSP-HC
CUNHA-NETO, Edecio FMUSP-HC
CHEVILLARD, Christophe
dc.date.issued 2016
dc.identifier.citation JOURNAL OF INFECTIOUS DISEASES, v.214, n.1, p.161-165, 2016
dc.identifier.issn 0022-1899
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/16129
dc.description.abstract Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of the lncRNA known as myocardial infarction-associated transcript (MIAT) has been associated with myocardial infarction. Chagas disease causes a severe inflammatory dilated chronic cardiomyopathy (CCC). We investigated the role of MIAT in CCC. A whole-transcriptome analysis of heart biopsy specimens and formalin-fixed, paraffin-embedded samples revealed that MIAT was overexpressed in patients with CCC, compared with subjects with noninflammatory dilated cardiomyopathy and controls. These results were confirmed in a mouse model. Results suggest that MIAT is a specific biomarker of CCC.
dc.description.sponsorship · Institut National de la Sante et de la Recherche Medicale, Aix-Marseille University (Direction des Relations Internationales)
· USP-COFECUB program
· ARCUS II PACA Bresil program
· Brazilian National Research Council
· Sao Paulo State Research Funding Agency (FAPESP)
· French National Research Agency
· FAPESP
dc.language.iso eng
dc.publisher OXFORD UNIV PRESS INC
dc.relation.ispartof Journal of Infectious Diseases
dc.rights restrictedAccess
dc.subject dilated; cardiomyopathy; Chagas disease; lncRNA; MIAT; biomarker
dc.subject.other miat; heart; risk
dc.title Myocardial Infarction-Associated Transcript, a Long Noncoding RNA, Is Overexpressed During Dilated Cardiomyopathy Due to Chronic Chagas Disease
dc.type article
dc.rights.holder Copyright OXFORD UNIV PRESS INC
dc.description.group LIM/11
dc.description.group LIM/19
dc.identifier.doi 10.1093/infdis/jiw095
dc.identifier.pmid 26951817
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author FRADE, Amanda Farage:FM:
hcfmusp.author FERREIRA, Ludmila Rodrigues Pinto:HC:INCOR
hcfmusp.author BARON, Monique Andrade:FM:
hcfmusp.author BENVENUTI, Luiz Alberto:HC:INCOR
hcfmusp.author NAVARRO, Isabela Cunha:FM:
hcfmusp.author FERREIRA, Frederico Moraes:FM:MCM
hcfmusp.author CANDIDO, Darlan da Silva:FM:
hcfmusp.author GAIOTTO, Fabio Antonio:HC:INCOR
hcfmusp.author BACAL, Fernando:HC:INCOR
hcfmusp.author POMERANTZEFF, Pablo:FM:MCP
hcfmusp.author SANTOS, Ronaldo Honorato Barros:HC:INCOR
hcfmusp.author KALIL, Jorge:FM:MCM
hcfmusp.author CUNHA-NETO, Edecio:FM:MCM
hcfmusp.author.external · LAUGIER, Laurie:Aix Marseille Univ, INSERM, GIMP, UMR S906, F-13385 Marseille, France
· TEIXEIRA, Priscila Camillo:Univ Sao Paulo, Sch Med, Lab Immunol, Sao Paulo, Brazil; Univ Sao Paulo, Sch Med, Div Clin Immunol & Allergy, Sao Paulo, Brazil; Natl Inst Sci & Technol, Inst Invest Immunol, Sao Paulo, Brazil
· CABANTOUS, Sandrine:Aix Marseille Univ, INSERM, GIMP, UMR S906, F-13385 Marseille, France
· CHEVILLARD, Christophe:Aix Marseille Univ, INSERM, GIMP, UMR S906, F-13385 Marseille, France
hcfmusp.origem.id WOS:000379822200022
hcfmusp.origem.id 2-s2.0-84979221784
hcfmusp.publisher.city CARY
hcfmusp.publisher.country USA
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dc.description.index MEDLINE
dc.identifier.eissn 1537-6613
hcfmusp.citation.scopus 14
hcfmusp.citation.wos 12
hcfmusp.affiliation.country Brasil
hcfmusp.affiliation.country França


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