Incidence, Duration, Persistence, and Factors Associated With High-risk Anal Human Papillomavirus Persistence Among HIV-negative Men Who Have Sex With Men: A Multinational Study

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art_NYITRAY_Incidence_Duration_Persistence_and_Factors_Associated_With_Highrisk_2016.PDF (388.39 KB)
Citações na Scopus
41
Tipo de produção
article
Data de publicação
2016
Editora
OXFORD UNIV PRESS INC
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
NYITRAY, Alan G.
SILVA, Roberto J. Carvalho da
CHANG, Mihyun
INGLES, Donna J.
ABRAHAMSEN, Martha
PAPENFUSS, Mary
LIN, Hui-Yi
SALMERON, Jorge
QUITERIO, Manuel
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
CLINICAL INFECTIOUS DISEASES, v.62, n.11, p.1367-1374, 2016
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background. Given high rates of anal disease, we investigated the natural history of high-risk anal human papillomavirus (HPV) among a multinational group of men who have sex with men (MSM) aged 18-64 years. Methods. Anal specimens from human immunodeficiency virus-negative men from Brazil, Mexico, and the United States were genotyped. Over 2 years, 406 MSM provided evaluable specimens every 6 months for >= 2 visits. These men were stratified into men who have sex only with men (MSOM, n = 70) and men who have sex with women and men (MSWM, n = 336). Persistence was defined as >= 12 months' type-specific duration and could begin with either a prevalent or incident infection. Prevalence ratios and 95% confidence intervals were calculated by Poisson regression. Results. Median follow-up time was 2.1 years. Retention was 82%. Annual cumulative incidence of 9-valent vaccine types was 19% and 8% among MSOM and MSWM, respectively (log-rank P =.02). Duration of anal HPV did not differ for MSOM and MSWM and was a median of 6.9 months for HPV-16 after combining men from the 2 groups. Among men with prevalent high-risk infection (n = 106), a total of 36.8%, retained the infection for at least 24 months. For those with prevalent HPV-16 (n = 27), 29.6% were persistent for at least 24 months. Persistence of high-risk HPV was associated with number of male anal sex partners and inversely associated with number of female sex partners. Conclusions. MSM with prevalent high-risk HPV infection should be considered at increased risk for nontransient infection.
Palavras-chave
natural history, anal cancer, anal condyloma, HPV DNA, prospective
URI
https://observatorio.fm.usp.br/handle/OPI/16156
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - LIM/24
Artigos e Materiais de Revistas Científicas - ODS/03