Regional lung perfusion estimated by electrical impedance tomography in a piglet model of lung collapse
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Citações na Scopus
143
Tipo de produção
article
Data de publicação
2012
Editora
AMER PHYSIOLOGICAL SOC
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Autores
SUAREZ-SIPMANN, Fernando
BOHM, Stephan H.
TUSMAN, Gerardo
MELO, Alexandre
MARIPUU, Enn
SANDSTROM, Mattias
HEDENSTIERNA, Goran
Autor de Grupo de pesquisa
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Citação
JOURNAL OF APPLIED PHYSIOLOGY, v.112, n.1, p.225-236, 2012
Resumo
Borges JB, Suarez-Sipmann F, Bohm SH, Tusman G, Melo A, Maripuu E, Sandstrom M, Park M, Costa EL, Hedenstierna G, Amato M. Regional lung perfusion estimated by electrical impedance tomography in a piglet model of lung collapse. J Appl Physiol 112: 225-236, 2012. First published September 29, 2011; doi: 10.1152/japplphysiol.01090.2010.-The assessment of the regional match between alveolar ventilation and perfusion in critically ill patients requires simultaneous measurements of both parameters. Ideally, assessment of lung perfusion should be performed in real-time with an imaging technology that provides, through fast acquisition of sequential images, information about the regional dynamics or regional kinetics of an appropriate tracer. We present a novel electrical impedance tomography (EIT)-based method that quantitatively estimates regional lung perfusion based on first-pass kinetics of a bolus of hypertonic saline contrast. Pulmonary blood flow was measured in six piglets during control and unilateral or bilateral lung collapse conditions. The first-pass kinetics method showed good agreement with the estimates obtained by single-photon-emission computerized tomography (SPECT). The mean difference (SPECT minus EIT) between fractional blood flow to lung areas suffering atelectasis was -0.6%, with a SD of 2.9%. This method outperformed the estimates of lung perfusion based on impedance pulsatility. In conclusion, we describe a novel method based on EIT for estimating regional lung perfusion at the bedside. In both healthy and injured lung conditions, the distribution of pulmonary blood flow as assessed by EIT agreed well with the one obtained by SPECT. The method proposed in this study has the potential to contribute to a better understanding of the behavior of regional perfusion under different lung and therapeutic conditions.
Palavras-chave
first-pass kinetics, pulmonary blood flow distribution
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