Repetitive transcranial magnetic stimulation and transcranial direct-current stimulation in neuropathic pain due to radiculopathy: a randomized sham-controlled comparative study

Imagem de Miniatura
Arquivos
art_ATTAL_Repetitive_transcranial_magnetic_stimulation_and_transcranial_directcurrent_stimulation_2016.PDF (328.1 KB)
Citações na Scopus
76
Tipo de produção
article
Data de publicação
2016
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
LIPPINCOTT WILLIAMS & WILKINS
Autores
ATTAL, Nadine
AYACHE, Samar S.
MHALLA, Alaa
BAUDIC, Sophie
JAZAT, Frederique
AHDAB, Rechdi
NEVES, Danusa O.
SOREL, Marc
LEFAUCHEUR, Jean-Pascal
Citação
PAIN, v.157, n.6, p.1224-1231, 2016
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
No study has directly compared the effectiveness of repetitive transcranial magnetic stimulation (rTMS) and transcranial direct-current stimulation (tDCS) in neuropathic pain (NP). In this 2-centre randomised double-blind sham-controlled study, we compared the efficacy of 10-Hz rTMS and anodal 2-mA tDCS of the motor cortex and sham stimulation contralateral to the painful area (3 daily sessions) in patients with NP due to lumbosacral radiculopathy. Average pain intensity (primary outcome) was evaluated after each session and 5 days later. Secondary outcomes included neuropathic symptoms and thermal pain thresholds for the upper limbs. We used an innovative design that minimised bias by randomly assigning patients to 1 of 2 groups: active rTMS and tDCS or sham rTMS and tDCS. For each treatment group (active or sham), the order of the sessions was again randomised according to a crossover design. In total, 51 patients were screened and 35 (51% women) were randomized. Active rTMS was superior to tDCS and sham in pain intensity (F = 2.89 and P = 0.023). Transcranial direct-current stimulation was not superior to sham, but its analgesic effects were correlated to that of rTMS (P = 0.046), suggesting common mechanisms of action. Repetitive transcranial magnetic stimulation lowered cold pain thresholds (P = 0.04) and its effect on cold pain was correlated with its analgesic efficacy (P = 0.006). However, rTMS had no impact on individual neuropathic symptoms. Thus, rTMS is more effective than tDCS and sham in patients with NP due to lumbosacral radiculopathy and may modulate the sensory and affective dimensions of pain.
Palavras-chave
rTMS, tDCS, Noninvasive brain stimulation, Neuropathic pain, Radiculopathy, Thermal threshold, NPSI
URI
https://observatorio.fm.usp.br/handle/OPI/16380
Referências
  1. Andre-Obadia N, 2006, CLIN NEUROPHYSIOL, V117, P1536, DOI 10.1016/j.clinph.2006.03.025
  2. Andre-Obadia N, 2011, PAIN, V152, P1233, DOI 10.1016/j.pain.2010.12.027
  3. Andre-Obadia N, 2008, NEUROLOGY, V9, P833
  4. Apkarian AV, 2010, TRANSLATIONAL PAIN R, P15
  5. Attal N, 2015, 22 WORLD C NEUR WCN
  6. Attal N, 2011, J PAIN, V12, P1080, DOI 10.1016/j.jpain.2011.05.006
  7. Attal N, 2011, PAIN, V152, P2836, DOI 10.1016/j.pain.2011.09.014
  8. Bestmann S, 2004, EUR J NEUROSCI, V19, P1950, DOI 10.1111/j.1460.9568.2004.03277.x
  9. Bouhassira D, 2004, PAIN, V108, P248, DOI 10.1016/j.pain.2003.12.024
  10. Bouhassira D, 2005, PAIN, V114, P29, DOI 10.1016/j.pain.2004.12.010
  11. Bouhassira D, 2008, PAIN, V136, P380, DOI 10.1016/j.pain.2007.08.013
  12. Cleeland C. S., 1994, Annals Academy of Medicine Singapore, V23, P129
  13. de Andrade DC, 2011, PAIN, V152, P320, DOI 10.1016/j.pain.2010.10.032
  14. Defrin R, 2007, ARCH PHYS MED REHAB, V88, P1574, DOI 10.1016/j.apmr.2007.07.025
  15. Soler MD, 2010, BRAIN, V133, P2565, DOI 10.1093/brain/awq184
  16. Dworkin RH, 2013, PAIN, V154, P2249, DOI 10.1016/j.pain.2013.06.004
  17. Finnerup NB, 2015, LANCET NEUROL, V14, P162, DOI 10.1016/S1474-4422(14)70251-0
  18. Fregni F, 2006, PAIN, V122, P197, DOI 10.1016/j.pain.2006.02.023
  19. Freynhagen R, 2009, CURR PAIN HEADACHE R, V13, P185, DOI 10.1007/s11916-009-0032-y
  20. Grachev ID, 2000, PAIN, V89, P7, DOI 10.1016/S0304-3959(00)00340-7
  21. Hodaj H, 2015, BRAIN STIMUL, V8, P801, DOI 10.1016/j.brs.2015.01.416
  22. Hosomi K, 2013, PAIN, V154, P1065, DOI 10.1016/j.pain.2013.03.016
  23. Johnson S, 2006, PAIN, V123, P187, DOI 10.1016/j.pain.2006.02.030
  24. Khedr EM, 2015, EUR J PAIN, V19, P519, DOI 10.1002/ejp.576
  25. Khedr EM, 2005, J NEUROL NEUROSUR PS, V76, P833, DOI 10.1136/jnnp.2004.055806
  26. Kim Yon Joon, 2013, Annals of Rehabilitation Medicine, V37, P766, DOI 10.5535/arm.2013.37.6.766
  27. Lefaucheur JP, 2006, NEUROLOGY, V67, P1568, DOI 10.1212/01.wnl.0000242731.10074.3c
  28. Lefaucheur JP, 2008, J NEUROL NEUROSUR PS, V79, P1044, DOI 10.1136/jnnp.2007.135327
  29. Lefaucheur JP, 2010, CLIN NEUROPHYSIOL, V121, P895, DOI 10.1016/j.clinph.2009.12.028
  30. Lefaucheur JP, 2014, CLIN NEUROPHYSIOL, V125, P2150, DOI 10.1016/j.clinph.2014.05.021
  31. Lefaucheur JP, 2008, BRAIN STIMUL, V1, P337, DOI 10.1016/j.brs.2008.07.003
  32. Lefaucheur JP, 2004, J NEUROL NEUROSUR PS, V75, P612, DOI 10.1136/jnnp.2003.022236
  33. Leung A, 2009, J PAIN, V10, P1205, DOI 10.1016/j.jpain.2009.03.010
  34. Mhalla A, 2010, PAIN, V149, P495, DOI 10.1016/j.pain.2010.03.009
  35. Mhalla A, 2011, PAIN, V152, P1478, DOI 10.1016/j.pain.2011.01.034
  36. Mori F, 2010, J PAIN, V11, P436, DOI 10.1016/j.jpain.2009.08.011
  37. Nahmias F, 2009, PAIN, V147, P224, DOI 10.1016/j.pain.2009.09.016
  38. Ngernyam N, 2015, CLIN NEUROPHYSIOL, V126, P382, DOI 10.1016/j.clinph.2014.05.034
  39. O'Connell NE, 2014, COCHRANE DB SYST REV, V4, DOI 10.1002/14651858.CD008208.PUB3
  40. Passard A, 2007, BRAIN, V130, P2661, DOI 10.1093/brain/awm189
  41. Picarelli H, 2010, J PAIN, V11, P1203, DOI 10.1016/j.jpain.2010.02.006
  42. Ranoux D, 2008, ANN NEUROL, V64, P274, DOI 10.1002/ana.21427
  43. Rossini PM, 2015, CLIN NEUROPHYSIOL, V126, P1071, DOI 10.1016/j.clinph.2015.02.001
  44. Roussel NA, 2013, CLIN J PAIN, V29, P625, DOI 10.1097/AJP.0b013e31826f9a71
  45. Rutkowski MD, 2002, SPINE, V27, P1604, DOI 10.1097/01.BRS.0000018792.91620.9E
  46. Souto G, 2014, CLIN J PAIN, V30, P809, DOI 10.1097/AJP.0000000000000037
  47. Sullivan MJL, 1995, PSYCHOL ASSESSMENT, V7, P524, DOI 10.1037//1040-3590.7.4.524
  48. Tinazzi M, 2000, J NEUROSCI, V20, P9277
  49. Treede RD, 2008, NEUROLOGY, V70, P1630, DOI 10.1212/01.wnl.0000282763.29778.59
  50. Yilmaz B, 2014, J SPINAL CORD MED, V37, P397, DOI 10.1179/2045772313Y.0000000172
  51. Yoo WK, 2008, NEUROIMAGE, V39, P1886, DOI 10.1016/j.neuroimage.2007.10.035
  52. ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x

Coleções
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC