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https://observatorio.fm.usp.br/handle/OPI/16443
Title: | Status of research and development of vaccines for Streptococcus pyogenes |
Authors: | STEER, Andrew C.; CARAPETIS, Jonathan R.; DALE, James B.; FRASER, John D.; GOOD, Michael F.; GUILHERME, Luiza; MORELAND, Nicole J.; MULHOLLAND, E. Kim; SCHODEL, Florian; SMEESTERS, Pierre R. |
Citation: | VACCINE, v.34, n.26, Special Issue, p.2953-2958, 2016 |
Abstract: | Streptococcus pyogenes is an important global pathogen, causing considerable morbidity and mortality, especially in low and middle income countries where rheumatic heart disease and invasive infections are common. There is a number of promising vaccine candidates, most notably those based on the M protein, the key virulence factor for the bacterium. Vaccines against Streptococcus pyogenes are considered as impeded vaccines because of a number of crucial barriers to development Considerable effort is needed by key players to bring current vaccine candidates through phase III clinical trials and there is a clear need to develop a roadmap for future development of current and new candidates. (C) 2016 World Health Organization; licensee Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.orgilicensesiby/3.0/). |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/19 Artigos e Materiais de Revistas Científicas - ODS/03 |
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