Exercise training attenuates the pressor response evoked by peripheral chemoreflex in rats with heart failure

Imagem de Miniatura
Arquivos
art_CALEGARI_Exercise_training_attenuates_the_pressor_response_evoked_by_2016.PDF (749.54 KB)
Citações na Scopus
6
Tipo de produção
article
Data de publicação
2016
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
Autores
CALEGARI, Leonardo
MOZZAQUATTRO, Bruna B.
ROSSATO, Douglas D.
QUAGLIOTTO, Edson
RASIA-FILHO, Alberto
LAGO, Pedro Dal
Citação
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, v.94, n.9, p.979-986, 2016
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The effects of exercise training (ExT) on the pressor response elicited by potassium cyanide (KCN) in the rat model of ischemia-induced heart failure (HF) are unknown. We evaluated the effects of ExT on chemoreflex sensitivity and its interaction with baroreflex in rats with HF. Wistar rats were divided into four groups: trained HF (Tr-HF), sedentary HF (Sed-HF), trained sham (Tr-Sham), and sedentary sham (Sed-Sham). Trained animals underwent to a treadmill running protocol for 8 weeks (60 m/day, 5 days/week, 16 m/min). After ExT, arterial pressure (AP), baroreflex sensitivity (BRS), peripheral chemoreflex (KCN: 100 mu g/kg body mass), and cardiac function were evaluated. The results demonstrate that ExT induces an improvement in BRS and attenuates the pressor response to KCN relative to the Sed-HF group (P < 0.05). The improvement in BRS was associated with a reduction in the pressor response following ExT in HF rats (P < 0.05). Moreover, ExT induced a reduction in left ventricular end-diastolic pressure and pulmonary congestion compared with the Sed-HF group (P < 0.05). The pressor response to KCN in the hypotensive state is decreased in sedentary HF rats. These results suggest that ExT improves cardiac function and BRS and attenuates the pressor response evoked by KCN in HF rats.
Palavras-chave
exercise training, autonomic dysfunction, baroreceptor reflex, chemoreceptor reflex, heart failure
URI
https://observatorio.fm.usp.br/handle/OPI/16464
Referências
  1. Abboud FM, 2010, AM J PHYSIOL-REG I, V298, pR1449, DOI 10.1152/ajpregu.00130.2010
  2. Al-Hesayen A, 2004, CIRCULATION, V109, P2862, DOI 10.1161/01.CIR.0000129313.73750.57
  3. Alves JP, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0110317
  4. Azevedo ER, 2000, J CARDIOVASC PHARM, V35, P129, DOI 10.1097/00005344-200001000-00017
  5. Barros RCH, 2002, AUTON NEUROSCI-BASIC, V97, P110, DOI 10.1016/S1566-0702(02)00050-4
  6. Bertagnolli M, 2008, AM J HYPERTENS, V21, P1188, DOI 10.1038/ajh.2008.270
  7. Chong AY, 2004, CIRCULATION, V110, P1794, DOI 10.1161/01.CIR.0000143073.60937.50
  8. DallAgo P, 1997, BRAZ J MED BIOL RES, V30, P119
  9. Dantas EM, 2013, AUTON NEUROSCI-BASIC, V177, P231, DOI 10.1016/j.autneu.2013.05.007
  10. Floras JS, 2009, J AM COLL CARDIOL, V54, P375, DOI 10.1016/j.jacc.2009.03.061
  11. Franchini KG, 1997, HYPERTENSION, V30, P699
  12. GRASSI G, 1995, CIRCULATION, V92, P3206
  13. HAIBARA AS, 1995, AM J PHYSIOL-HEART C, V269, pH1421
  14. Hambrecht R, 1997, J AM COLL CARDIOL, V29, P1067
  15. HEAD GA, 1987, J AUTONOM NERV SYST, V21, P203, DOI 10.1016/0165-1838(87)90023-3
  16. HEISTAD DD, 1974, J CLIN INVEST, V53, P1226, DOI 10.1172/JCI107669
  17. Heitzer T, 2005, ARTERIOSCL THROM VAS, V25, P1174, DOI 10.1161/01.ATV.0000166516.52477.81
  18. Hentschke VS, 2013, LASER MED SCI, V28, P1007, DOI 10.1007/s10103-012-1190-4
  19. Henze M, 2013, AM J PHYSIOL-HEART C, V304, pH444, DOI 10.1152/ajpheart.00763.2012
  20. Hottinger Daniel G, 2014, J Anaesthesiol Clin Pharmacol, V30, P462, DOI 10.4103/0970-9185.142799
  21. Hubert F, 2014, BRIT J PHARMACOL, V171, P5361, DOI 10.1111/bph.12853
  22. Hunt SA, 2005, CIRCULATION, V112, pE154, DOI 10.1161/CIRCULATIONHA.105.167586
  23. Jaenisch RB, 2011, J APPL PHYSIOL, V111, P1664, DOI 10.1152/japplphysiol.01245.2010
  24. Krylov S.S., 1968, ARTERIAL CHEMORECEPT, P103
  25. Kumar P, 2009, ADV EXP MED BIOL, V648, P223, DOI 10.1007/978-90-481-2259-2_26
  26. Li JH, 2004, CIRCULATION, V110, P3049, DOI 10.1161/01.CIR.0000147188.46287.1B
  27. Li YL, 2008, J APPL PHYSIOL, V105, P782, DOI 10.1152/japplphysiol.90533.2008
  28. LINDPAINTNER K, 1993, J MOL CELL CARDIOL, V25, P133, DOI 10.1006/jmcc.1993.1017
  29. Liu JL, 2000, CIRCULATION, V102, P1854
  30. Mandel DA, 2008, AM J PHYSIOL-HEART C, V295, pH1772, DOI 10.1152/ajpheart.216.2008
  31. McMurray JJV, 2012, EUR HEART J, V33, P1787, DOI 10.1093/eurheartj/ehs104
  32. MIURA M, 1972, J PHYSIOL-LONDON, V223, P525
  33. Morgan DR, 2004, EUR J HEART FAIL, V6, P901, DOI 10.1016/j.ejheart.2004.02.008
  34. Mortara A, 1997, CIRCULATION, V96, P3450
  35. Mousa TM, 2008, J APPL PHYSIOL, V104, P616, DOI 10.1152/japplphysiol.00601.2007
  36. Neckel H, 2012, CAN J PHYSIOL PHARM, V90, P525, DOI [10.1139/y2012-024, 10.1139/Y2012-024]
  37. Negrao CE, 2008, J APPL PHYSIOL, V104, P577, DOI 10.1152/japplphysiol.01368.2007
  38. Nunes RB, 2008, J APPL PHYSIOL, V104, P1641, DOI 10.1152/japplphysiol.00062.2008
  39. Nunes RB, 2013, CLINICS, V68, P876, DOI 10.6061/clinics/2013(06)24
  40. Patel KP, 2013, AM J PHYSIOL-HEART C, V305, pH173, DOI 10.1152/ajpheart.00009.2013
  41. Ponikowski P, 1997, CIRCULATION, V96, P2586
  42. Ponikowski P, 2001, CIRCULATION, V104, P544, DOI 10.1161/hc3101.093699
  43. Quagliotto E, 2008, NEUROSCIENCE, V157, P709, DOI 10.1016/j.neuroscience.2008.09.053
  44. Reddy MK, 2005, AM J PHYSIOL-REG I, V289, pR789, DOI 10.1152/ajpregu.00222.2005
  45. Rengo G, 2010, AM J PHYSIOL-HEART C, V298, pH2032, DOI 10.1152/ajpheart.00702.2009
  46. Rondon E, 2006, AM J PHYSIOL-HEART C, V291, pH2801, DOI 10.1152/ajpheart.01352.2005
  47. Sabino JPJ, 2013, AUTON NEUROSCI-BASIC, V179, P43, DOI 10.1016/j.autneu.2013.07.001
  48. Sakai S, 1996, J AM COLL CARDIOL, V28, P1580, DOI 10.1016/S0735-1097(96)00336-1
  49. Schmidt H, 2005, INT J CARDIOL, V98, P369, DOI 10.1016/j.ijcard.2004.01.002
  50. Smith SA, 2005, CIRCULATION, V111, P2056, DOI 10.1161/01.CIR.0000162473.10951.0A
  51. Sun SY, 1999, J APPL PHYSIOL, V86, P1264
  52. vandeBorne P, 1997, CIRCULATION, V95, P1449
  53. Veras-Silva AS, 1997, AM J PHYSIOL-HEART C, V273, pH2627
  54. Wan WH, 2007, AM J MED SCI, V334, P265, DOI 10.1097/MAJ.0b013e318068b5ed
  55. Wang WZ, 2008, AM J PHYSIOL-HEART C, V295, pH1216, DOI 10.1152/ajpheart.00557.2008
  56. Xing JH, 2015, MED SCI SPORT EXER, V47, P257, DOI 10.1249/MSS.0000000000000415
  57. Xu XH, 2008, J MOL CELL CARDIOL, V44, P114, DOI 10.1016/j.yjmcc.2007.10.004
  58. Zhang SJ, 2006, J PHYSIOL-LONDON, V572, P551, DOI 10.1113/jphysiol.2005.104521
  59. Zucker IH, 2012, HEART FAIL CLIN, V8, P87, DOI 10.1016/j.hfc.2011.08.007

Coleções
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/59
Artigos e Materiais de Revistas Científicas - ODS/03