Evaluation of hemodynamic effects of xenon in dogs undergoing hemorrhagic shock

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author FRANCESCHI, Ruben C. FMUSP-HC
AULER JR., Jose Otavio Costa FMUSP-HC
FIGUEIREDO, Luiz Francisco Poli de FMUSP-HC
dc.date.issued 2013
dc.identifier.citation CLINICS, v.68, n.2, p.231-237, 2013
dc.identifier.issn 1807-5932
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/1690
dc.description.abstract OBJECTIVES: The anesthetic gas xenon is reported to preserve hemodynamic stability during general anesthesia. However, the effects of the gas during shock are unclear. The objective of this study was to evaluate the effect of Xe on hemodynamic stability and tissue perfusion in a canine model of hemorrhagic shock. METHOD: Twenty-six dogs, mechanically ventilated with a fraction of inspired oxygen of 21% and anesthetized with etomidate and vecuronium, were randomized into Xenon (Xe; n = 13) or Control (C; n = 13) groups. Following hemodynamic monitoring, a pressure-driven shock was induced to reach an arterial pressure of 40 mmHg. Hemodynamic data and blood samples were collected prior to bleeding, immediately after bleeding and 5, 20 and 40 minutes following shock. The Xe group was treated with 79% Xe diluted in ambient air, inhaled for 20 minutes after shock. RESULT: The mean bleeding volume was 44 mL.kg(-1) in the C group and 40 mL.kg(-1) in the Xe group. Hemorrhage promoted a decrease in both the cardiac index (p<0.001) and mean arterial pressure (p<0.001). These changes were associated with an increase in lactate levels and worsening of oxygen transport variables in both groups (p<0.05). Inhalation of xenon did not cause further worsening of hemodynamics or tissue perfusion markers. CONCLUSIONS: Xenon did not alter hemodynamic stability or tissue perfusion in an experimentally controlled hemorrhagic shock model. However, further studies are necessary to validate this drug in other contexts.
dc.language.iso eng
dc.relation.ispartof Clinics
dc.rights openAccess
dc.subject Xenon; Hemorrhagic Shock; General Anesthesia
dc.subject.other cardiovascular risk; propofol anesthesia; isoflurane; recovery; surgery; volume; pigs
dc.title Evaluation of hemodynamic effects of xenon in dogs undergoing hemorrhagic shock
dc.type article
dc.rights.holder Copyright HOSPITAL CLINICAS, UNIV SAO PAULO
dc.description.group LIM/08
dc.identifier.doi 10.6061/clinics/2013(02)OA18
dc.identifier.pmid 23525321
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author FRANCESCHI, Ruben C.:HC:INCOR
hcfmusp.author MALBOUISSON, Luiz:HC:ICHC
hcfmusp.author YOSHINAGA, Eduardo:HC:ICHC
hcfmusp.author AULER JR., Jose Otavio Costa:FM:MCG
hcfmusp.author FIGUEIREDO, Luiz Francisco Poli de:FM:MCG
hcfmusp.author CARMONA, Maria Jose C.:FM:MCG
hcfmusp.origem.id 2-s2.0-84875664495
hcfmusp.origem.id WOS:000316764000018
hcfmusp.origem.id SCIELO:S1807-59322013000200018
hcfmusp.publisher.city SAO PAULO
hcfmusp.publisher.country BRAZIL
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dc.description.index MEDLINE
hcfmusp.citation.scopus 3
hcfmusp.citation.wos 2

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