Urinary Retinol-Binding Protein: Relationship to Renal Function and Cardiovascular Risk Factors in Chronic Kidney Disease
Carregando...
Citações na Scopus
33
Tipo de produção
article
Data de publicação
2016
Editora
PUBLIC LIBRARY SCIENCE
Indexadores
Título da Revista
ISSN da Revista
Título do Volume
Autores
MOREIRA, Silvia Regina
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
PLOS ONE, v.11, n.9, article ID e0162782, 10p, 2016
Resumo
The role of urinary retinol-binding protein (RBP) as a biomarker of CKD in proximal tubular diseases, glomerulopathies and in transplantation is well established. However, whether urinary RBP is also a biomarker of renal damage and CKD progression in general CKD is not known. In this study, we evaluated the association of urinary RBP with renal function and cardiovascular risk factors in the baseline data of the Progredir Study, a CKD cohort in Sao Paulo, Brazil, comprising 454 participants with stages 3 and 4 CKD. In univariate analysis, urinary RBP was inversely related to estimated glomerular filtration rate (CKD-EPI eGFR) and several cardiovascular risk factors. After adjustments, however, only CKD-EPI eGFR, albuminuria, systolic blood pressure, anemia, acidosis, and left atrium diameter remained significantly related to urinary RBP. The inverse relationship of eGFR to urinary RBP (beta-0.02 +/- 95CI -0.02; -0.01, p<0.0001 for adjusted model) remained in all strata of albuminuria, even after adjustments: in normoalbuminuria (beta-0.008 +/- 95CI (-0.02; -0.001, p = 0.03), in microalbuminuria (beta-0.02 +/- 95CI (-0.03; -0.02, p<0,0001) and in macroalbuminuria (beta-0.02 +/- 95CI (-0.03; -0.01, p<0,0001). Lastly, urinary RBP was able to significantly increase the accuracy of a logistic regression model (adjusted for sex, age, SBP, diabetes and albuminuria) in diagnosing eGFR<35 ml/min/1.73m(2) (AUC 0,77, 95% CI 0,72-0,81 versus AUC 0,71, 95% CI 0,65-0,75, respectively; p = 0,05). Our results suggest that urinary RBP is significantly associated to renal function in CKD in general, a finding that expands the interest in this biomarker beyond the context of proximal tubulopathies, glomerulopathies or transplantation. Urinary RBP should be further explored as a predictive marker of CKD progression.
Palavras-chave
Referências
- Abel ED, 2001, NATURE, V409, P729, DOI 10.1038/35055575
- Agatston AS, 1990, J AM COLL CARDIOL, P15
- BERNARD A, 1988, CLIN CHIM ACTA, V171, P85, DOI 10.1016/0009-8981(88)90293-8
- Camara NOS, 2001, TRANSPLANT P, V33, P2129, DOI 10.1016/S0041-1345(01)01971-6
- Chistensen EI, 1999, J AM SOC NEPHROL, V10, P685
- Cruz DN, 2010, INT J NEPHROL, DOI 10.4061/2011/351291
- Donadio C, 2010, AM J PHYSIOL-RENAL, V299, pF1407, DOI 10.1152/ajprenal.00507.2009
- Flower DR, 1996, BIOCHEM J, V318, P1
- Graham TE, 2006, NEW ENGL J MED, V354, P2552, DOI 10.1056/NEJMoa054862
- Hebert K, 2010, EUR J HEART FAIL, V12, P861, DOI 10.1093/eurjhf/hfq077
- HOLM J, 1993, CLIN CHEM, V39, P517
- Holm J, 1994, Kidney Int Suppl, V47, pS105
- Hosaka B, 2003, TRANSPLANT P, V35, P1341, DOI 10.1016/S0041-1345(03)00380-4
- Kirsztajn GM, 2002, NEPHRON, V90, P424
- Krolewski AS, 2014, DIABETES CARE, V37, P226, DOI 10.2337/dc13-0985
- Levey AS, 2009, ANN INTERN MED, V150, P604
- Pallet N, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0084708
- PEREIRA AB, 1993, CLIN CHEM, V39, P472
- Perkins BA, 2010, KIDNEY INT, V77, P57, DOI 10.1038/ki.2009.399
- PETERSON PA, 1971, J BIOL CHEM, V246, P44
- Ronco C, 2009, BLOOD PURIFICAT, V27, P114, DOI 10.1159/000167018
- Salem Mona A K, 2002, Pediatr Diabetes, V3, P37, DOI 10.1034/j.1399-5448.2002.30107.x
- SESSO R, 1992, ANN INTERN MED, V116, P905
- SHEPHERD PR, 1993, J BIOL CHEM, V268, P22243
- Titan SM, 2012, J DIABETES COMPLICAT, V26, P546, DOI 10.1016/j.jdiacomp.2012.06.006
- Yang Q, 2005, NATURE, V436, P356, DOI 10.1038/nature03711
Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HU
Artigos e Materiais de Revistas Científicas - LIM/13
Artigos e Materiais de Revistas Científicas - LIM/20
Artigos e Materiais de Revistas Científicas - LIM/51
Artigos e Materiais de Revistas Científicas - ODS/03
Artigos e Materiais de Revistas Científicas - HU
Artigos e Materiais de Revistas Científicas - LIM/13
Artigos e Materiais de Revistas Científicas - LIM/20
Artigos e Materiais de Revistas Científicas - LIM/51
Artigos e Materiais de Revistas Científicas - ODS/03