ESMO consensus guidelines for the management of patients with metastatic colorectal cancer

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Citações na Scopus
2501
Tipo de produção
article
Data de publicação
2016
Título da Revista
ISSN da Revista
Título do Volume
Editora
OXFORD UNIV PRESS
Autores
CUTSEM, E. Van
CERVANTES, A.
ADAM, R.
SOBRERO, A.
KRIEKEN, J. H. Van
ADERKA, D.
AGUILAR, E. Aranda
BARDELLI, A.
BENSON, A.
BODOKY, G.
Citação
ANNALS OF ONCOLOGY, v.27, n.8, p.1386-1422, 2016
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The clinical outcome for patients with metastatic CRC (mCRC) has improved greatly over the last 20 years. These ESMO consensus guidelines have been developed based on the current available evidence to provide a series of evidence-based recommendations to assist in the treatment and management of patients with mCRC in this rapidly evolving treatment setting.Colorectal cancer (CRC) is one of the most common malignancies in Western countries. Over the last 20 years, and the last decade in particular, the clinical outcome for patients with metastatic CRC (mCRC) has improved greatly due not only to an increase in the number of patients being referred for and undergoing surgical resection of their localised metastatic disease but also to a more strategic approach to the delivery of systemic therapy and an expansion in the use of ablative techniques. This reflects the increase in the number of patients that are being managed within a multidisciplinary team environment and specialist cancer centres, and the emergence over the same time period not only of improved imaging techniques but also prognostic and predictive molecular markers. Treatment decisions for patients with mCRC must be evidence-based. Thus, these ESMO consensus guidelines have been developed based on the current available evidence to provide a series of evidence-based recommendations to assist in the treatment and management of patients with mCRC in this rapidly evolving treatment setting.
Palavras-chave
colorectal cancer, ESMO, consensus, clinical practice guidelines
Referências
  1. Adam R, 2011, J CLIN ONCOL, V29
  2. Adam R, 2004, ANN SURG, V240, P644, DOI 10.1097/01.sla.0000141198.92114.16
  3. Adam R, 2012, ONCOLOGIST, V17, P1225, DOI 10.1634/theoncologist.2012-0121
  4. Adam R, 2010, ANN SURG, V252, P774, DOI 10.1097/SLA.0b013e3181fcf3e3
  5. Adams RA, 2011, LANCET ONCOL, V12, P642, DOI 10.1016/S1470-2045(11)70102-4
  6. Al-Mulla F, 1998, J PATHOL, V185, P130, DOI 10.1002/(SICI)1096-9896(199806)185:2<130::AID-PATH85>3.0.CO;2-M
  7. Albanese I, 2004, BIOCHEM BIOPH RES CO, V325, P784, DOI 10.1016/j.bbrc.2004.10.111
  8. Alfonso P Garcia, 2014, ANN ONCOL S4, V25
  9. Amado RG, 2008, J CLIN ONCOL, V26, P1626, DOI 10.1200/JCO.2007.14.7116
  10. Ambrosino G, 2009, ANTICANCER RES, V29, P3381
  11. Arber DA, 2002, APPL IMMUNOHISTO M M, V10, P183, DOI 10.1097/00022744-200206000-00015
  12. Artale S, 2008, J CLIN ONCOL, V26, P4217, DOI 10.1200/JCO.2008.18.7286
  13. Aung K L, 2010, Hugo J, V4, P11, DOI 10.1007/s11568-011-9149-2
  14. Babic A, 2010, METHODS, V52, P287, DOI 10.1016/j.ymeth.2010.08.012
  15. Baldus SE, 2010, CLIN CANCER RES, V16, P790, DOI 10.1158/1078-0432.CCR-09-2446
  16. Barbarino JM, 2014, PHARMACOGENET GENOM, V24, P177, DOI 10.1097/FPC.0000000000000024
  17. Bardelli A, 2010, J CLIN ONCOL, V28, P1254, DOI 10.1200/JCO.2009.24.6116
  18. Bartolotta TV, 2010, RADIOL MED, V115, P714, DOI 10.1007/s11547-010-0506-3
  19. Bennouna J, 2013, LANCET ONCOL, V14, P29, DOI 10.1016/S1470-2045(12)70477-1
  20. Beretta GD, 2013, MED ONCOL, V30, DOI 10.1007/s12032-013-0486-y
  21. Bertotti A, 2011, CANCER DISCOV, V1, P508, DOI 10.1158/2159-8290.CD-11-0109
  22. Bettegowda C, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3007094
  23. Bettstetter M, 2007, CLIN CANCER RES, V13, P3221, DOI 10.1158/1078-0432.CCR-06-3064
  24. Bhutiani N, 2015, WORLD J SURG
  25. BLOMGREN H, 1995, ACTA ONCOL, V34, P861
  26. Bokemeyer C, 2011, ANN ONCOL, V22, P1535, DOI 10.1093/annonc/mdq632
  27. Bokemeyer C, 2015, EUR J CANCER, V51, P1243, DOI 10.1016/j.ejca.2015.04.007
  28. Bokemeyer C, 2009, J CLIN ONCOL, V27, P663, DOI 10.1200/JCO.2008.20.8397
  29. CancerLevy E, 1998, J CLIN ONCOL, V16, P3537
  30. Cao C, 2009, ANN SURG ONCOL, V16, P2152, DOI 10.1245/s10434-009-0487-4
  31. Carotenuto P, 2010, PHARMACOGENOMICS, V11, P1169, DOI [10.2217/pgs.10.86, 10.2217/PGS.10.86]
  32. Cascinu S, 2015, EUR J CANC SS3, V51
  33. Cassidy J, 2008, J CLIN ONCOL, V26, P2006, DOI 10.1200/JCO.2007.14.9898
  34. Cejas P, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0008199
  35. Chafin D, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054138
  36. Chibaudel B, 2009, J CLIN ONCOL, V27, P5727, DOI 10.1200/JCO.2009.23.4344
  37. Chun YS, 2009, JAMA-J AM MED ASSOC, V302, P2338, DOI 10.1001/jama.2009.1755
  38. Ciardiello F, 2014, ANN ONCOL, V25, P1756, DOI 10.1093/annonc/mdu230
  39. Clavien P, 2007, NEW ENGL J MED, V356, P1545, DOI 10.1056/NEJMra065156
  40. Cohen SJ, 2008, J CLIN ONCOL, V26, P3213, DOI 10.1200/JCO.2007.15.8923
  41. Collettini F, 2012, ROFO-FORTSCHR RONTG, V184, P316, DOI 10.1055/s-0031-1299101
  42. Comito T, 2014, BMC CANCER, V14, DOI 10.1186/1471-2407-14-619
  43. Corcoran RB, 2012, CANCER DISCOV, V2, P227, DOI 10.1158/2159-8290.CD-11-0341
  44. Corcoran RB, 2015, J CLIN ONCOL, V33, P4023, DOI 10.1200/JCO.2015.63.2471
  45. Cotte E, 2009, CANCER J, V15, P243, DOI 10.1097/PPO.0b013e3181a58d67
  46. Cremolini C, 2015, ANN ONCOL, V26, P2092, DOI 10.1093/annonc/mdv290
  47. Cremolini C, 2015, ANN ONCOL, V26, P1188, DOI 10.1093/annonc/mdv112
  48. Cremolini C, 2014, ANN ONCOL S4, V24
  49. Cremolini C, 2015, LANCET ONCOL, V16, P1306, DOI 10.1016/S1470-2045(15)00122-9
  50. Cremolini C, 2015, NEW ENGL J MED, V372, P291, DOI 10.1056/NEJMc1413996
  51. Cunningham D, 1998, LANCET, V352, P1413, DOI 10.1016/S0140-6736(98)02309-5
  52. Cunningham D, 2004, NEW ENGL J MED, V351, P337, DOI 10.1056/NEJMoa033025
  53. Cunningham D, 2013, LANCET ONCOL, V14, P1077, DOI 10.1016/S1470-2045(13)70154-2
  54. Dancey JE, 2010, CLIN CANCER RES, V16, P1745, DOI 10.1158/1078-0432.CCR-09-2167
  55. Dawson SJ, 2013, NEW ENGL J MED, V368, P1199, DOI 10.1056/NEJMoa1213261
  56. de Gramont A, 2000, J CLIN ONCOL, V18, P2938
  57. De Mattos-Arruda L, 2014, ANN ONCOL, V25, P1729, DOI 10.1093/annonc/mdu239
  58. deGramont A, 1997, J CLIN ONCOL, V15, P808
  59. Des Guetz G, 2007, ANTICANCER RES, V27, P2715
  60. Des Guetz G, 2009, TARGET ONCOL, V4, P57, DOI 10.1007/s11523-008-0103-8
  61. Diaz LA, 2014, J CLIN ONCOL, V32, P579, DOI 10.1200/JCO.2012.45.2011
  62. Diaz LA, 2012, NATURE, V486, P537, DOI 10.1038/nature11219
  63. Diaz-Rubio E, 2012, ONCOLOGIST, V17, P15, DOI 10.1634/theoncologist.2011-0249
  64. Dijkstra JR, 2013, VIRCHOWS ARCH, V462, P39, DOI 10.1007/s00428-012-1356-2
  65. Domingo E, 2005, ONCOGENE, V24, P3995, DOI 10.1038/sj.onc.1208569
  66. Douillard JY, 2014, ANN ONCOL, V25, P1346, DOI 10.1093/annonc/mdu141
  67. Douillard JY, 2010, J CLIN ONCOL, V28, P4697, DOI 10.1200/JCO.2009.27.4860
  68. Douillard JY, 2013, NEW ENGL J MED, V369, P1023, DOI 10.1056/NEJMoa1305275
  69. Douillard JY, 2000, ONCOLOGY-NY, V14, P51
  70. Dykewicz CA, 2001, CLIN INFECT DIS, V33, P139, DOI 10.1086/321805
  71. Elias D, 2014, EJSO-EUR J SURG ONC, V40, P1467, DOI 10.1016/j.ejso.2014.06.006
  72. Elias D, 2009, J CLIN ONCOL, V27, P681, DOI 10.1200/JCO.2008.19.7160
  73. Engel KB, 2011, ARCH PATHOL LAB MED, V135, P537, DOI 10.1043/2010-0702-RAIR.1
  74. Etienne-Grimaldi MC, 2008, CLIN CANCER RES, V14, P4830, DOI 10.1158/1078-0432.CCR-07-4906
  75. European Medicines Agency, 2015, CHMP SUMM OP ERB
  76. Evrard S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0114404
  77. Falcone A, 2007, J CLIN ONCOL, V25, P1670, DOI 10.1200/JCO.2006.09.0928
  78. Ferlay J, 2013, EUR J CANCER, V49, P1374, DOI 10.1016/j.ejca.2012.12.027
  79. Ferlay J, 2015, INT J CANCER, V136, pE359, DOI 10.1002/ijc.29210
  80. Filippi AR, 2014, TECHNOL CANCER RES T, V13, P37, DOI 10.7785/tcrt.2012.500355
  81. Fiorentini G, 2012, ANTICANCER RES, V32, P1387
  82. Floriani I, 2010, J MAGN RESON IMAGING, V31, P19, DOI 10.1002/jmri.22010
  83. Folprecht G, 2005, ANN ONCOL, V16, P1311, DOI 10.1093/annonc/mdi246
  84. Folprecht G, 2014, ANN ONCOL, V25, P1018, DOI 10.1093/annonc/mdu088
  85. Folprecht G, 2010, LANCET ONCOL, V11, P38, DOI 10.1016/S1470-2045(09)70330-4
  86. Fong Y, 1999, ANN SURG, V230, P309, DOI 10.1097/00000658-199909000-00004
  87. Forshew T, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3003726
  88. Fuchs CS, 2007, J CLIN ONCOL, V25, P4779, DOI 10.1200/JCO.2007.11.3357
  89. Fumagalli I, 2012, RADIAT ONCOL, V7, DOI 10.1186/1748-717X-7-164
  90. Garlipp B, 2014, HEPATOLOGY, V59, P1864, DOI 10.1002/hep.26947
  91. Garufi C, 2010, BRIT J CANCER, V103, P1542, DOI 10.1038/sj.bjc.6605940
  92. Geva R, 2013, ONCOTARGETS THER, V6, P53, DOI 10.2147/OTT.S41383
  93. Giantonio BJ, 2007, J CLIN ONCOL, V25, P1539, DOI 10.1200/JCO.2006.09.6305
  94. Goldstein J, 2014, ANN ONCOL, V25, P1032, DOI 10.1093/annonc/mdu100
  95. Goodman KA, 2010, INT J RADIAT ONCOL, V78, P486, DOI 10.1016/j.ijrobp.2009.08.020
  96. Gormally E, 2007, MUTAT RES-REV MUTAT, V635, P105, DOI 10.1016/j.mrrev.2006.11.002
  97. Grothey A, 2004, J CLIN ONCOL, V22, P1209, DOI 10.1200/JCO.2004.11.037
  98. Grothey A, 2005, J CLIN ONCOL, V23, P9441, DOI 10.1200/JCO.2005.04.4792
  99. Grothey A, 2013, LANCET, V381, P303, DOI 10.1016/S0140-6736(12)61900-X
  100. Gruenberger B, 2008, J CLIN ONCOL, V26, P1830, DOI 10.1200/JCO.2007.13.7679
  101. Gruenberger T, 2015, ANN ONCOL, V26, P702, DOI 10.1093/annonc/mdu580
  102. Guinney J, 2015, NAT MED, V21, P1350, DOI 10.1038/nm.3967
  103. Haller DG, 2008, J CLIN ONCOL, V26, P4544, DOI 10.1200/JCO.2008.17.1249
  104. Hecht JR, 2007, CANCER, V110, P980, DOI 10.1002/cncr.22915
  105. Hecht JR, 2015, CLIN COLORECTAL CANC, V14, P72, DOI 10.1016/j.clcc.2014.12.009
  106. Hegewisch-Becker S, 2015, LANCET ONCOL, V16, P1355, DOI 10.1016/S1470-2045(15)00042-X
  107. Heinemann V, 2014, ANN ONCOL S2, V25
  108. Heinemann V, 2014, LANCET ONCOL, V15, P1065, DOI 10.1016/S1470-2045(14)70330-4
  109. Hendlisz A, 2012, ANN ONCOL, V23, P1687, DOI 10.1093/annonc/mdr554
  110. Hendlisz A, 2010, J CLIN ONCOL, V28, P3687, DOI 10.1200/JCO.2010.28.5643
  111. Higgins MJ, 2012, CLIN CANCER RES, V18, P3462, DOI 10.1158/1078-0432.CCR-11-2696
  112. Hoskins JM, 2007, J NATL CANCER I, V99, P1290, DOI 10.1093/jnci/djm115
  113. Hoyer M, 2006, ACTA ONCOL, V45, P823, DOI 10.1080/02841860600904854
  114. Hurwitz H, 2004, NEW ENGL J MED, V350, P2335, DOI 10.1056/NEJMoa032691
  115. Hyman DM, 2015, NEW ENGL J MED, V373, P726, DOI 10.1056/NEJMoa1502309
  116. Italiano A, 2010, ANN SURG ONCOL, V17, P1429, DOI 10.1245/s10434-009-0864-z
  117. Jhawer M, 2008, CANCER RES, V68, P1953, DOI 10.1158/0008-5472.CAN-07-5659
  118. Johnsson A, 2013, ANN ONCOL, V24, P2335, DOI 10.1093/annonc/mdt236
  119. Jones RP, 2014, SURG ONCOL, V23, P53, DOI 10.1016/j.suronc.2014.02.002
  120. Juo YY, 2014, ANN ONCOL, V25, P2314, DOI 10.1093/annonc/mdu149
  121. Kabbinavar F, 2008, ONCOLOGY-BASEL, V75, P215, DOI 10.1159/000163850
  122. Kanas Gena P, 2012, Clin Epidemiol, V4, P283, DOI 10.2147/CLEP.S34285
  123. Karapetis CS, 2008, NEW ENGL J MED, V359, P1757, DOI 10.1056/NEJMoa0804385
  124. Karapetis CS, 2014, CLIN CANCER RES, V20, P744, DOI 10.1158/1078-0432.CCR-13-0606
  125. Kashima M, 2011, AM J ROENTGENOL, V197, pW576, DOI 10.2214/AJR.11.6408
  126. Kavuri SM, 2015, CANCER DISCOV, V5, P832, DOI 10.1158/2159-8290.CD-14-1211
  127. Kemeny N, 2009, ANN ONCOL, V20, P1236, DOI 10.1093/annonc/mdn769
  128. Kerr KM, 2014, ANN ONCOL, V25, P1681, DOI 10.1093/annonc/mdu145
  129. Khattak MA, 2012, CLIN COLORECTAL CANC, V11, P247, DOI 10.1016/j.clcc.2012.06.004
  130. Kim JE, 2011, CANCER SCI, V102, P1706, DOI 10.1111/j.1349-7006.2011.02009.x
  131. Kircher SM, 2015, ONCOLOGIST, V20, P14, DOI 10.1634/theoncologist.2014-0252
  132. Knijn N, 2011, BRIT J CANCER, V104, P1020, DOI 10.1038/bjc.2011.26
  133. Koeberle D, 2015, ANN ONCOL, V26, P709, DOI 10.1093/annonc/mdv011
  134. Kohne CH, 2008, ANN ONCOL, V19, P920, DOI 10.1093/annonc/mdm544
  135. Koopman M, 2007, LANCET, V370, P135, DOI 10.1016/S0140-6736(07)61086-1
  136. Kopetz S, 2015, J CLIN ONCOL, V33, P4032, DOI 10.1200/JCO.2015.63.2497
  137. Kozloff M, 2009, ONCOLOGIST, V14, P862, DOI 10.1634/theoncologist.2009-0071
  138. Labianca R, 2011, ANN ONCOL, V22, P1236, DOI 10.1093/annonc/mdq580
  139. Laurent-Puig P, 2009, J CLIN ONCOL, V27, P5924, DOI 10.1200/JCO.2008.21.6796
  140. Le DT, 2015, NEW ENGL J MED, V372, P2509, DOI 10.1056/NEJM0A1500596
  141. Lee MT, 2009, J CLIN ONCOL, V27, P1585, DOI 10.1200/JCO.2008.20.0600
  142. Lencioni R, 2008, LANCET ONCOL, V9, P621, DOI 10.1016/S1470-2045(08)70155-4
  143. Lenz HJ, 2014, ANN ONCOL S5, V25
  144. Li J, 2015, LANCET ONCOL, V16, P619, DOI 10.1016/S1470-2045(15)70156-7
  145. Li J, 2015, SMART STRUCT SYST, V15, P15
  146. Lievre A, 2009, BMC CANCER, V9, DOI 10.1186/1471-2407-9-347
  147. Liu DM, 2015, FUTURE ONCOL, V11, P1421, DOI 10.2217/fon.15.3
  148. LOSI L, 1992, EUR J CANCER, V28A, P1115, DOI 10.1016/0959-8049(92)90468-H
  149. Loughrey MB, 2007, FAM CANCER, V6, P301, DOI 10.1007/s10689-007-9124-1
  150. Loupakis F, 2009, J CLIN ONCOL, V27, P2622, DOI 10.1200/JCO.2008.20.2796
  151. Loupakis F, 2014, NEW ENGL J MED, V371, P1609, DOI 10.1056/NEJMoa1403108
  152. Maffione AM, 2015, EUR J NUCL MED MOL I, V42, P152, DOI 10.1007/s00259-014-2930-4
  153. Mansmann UR, 2012, J CLIN ONCOL, V30
  154. Mansmann UR, 2012, J CLIN ONCOL S4, V30
  155. Marisa L, 2013, PLOS MED, V10, DOI 10.1371/journal.pmed.1001453
  156. Marsh S, 2010, PHARMACOGENOMICS, V11, P1003, DOI [10.2217/pgs.10.95, 10.2217/PGS.10.95]
  157. Martin RCG, 2015, CANCER-AM CANCER SOC, V121, P3649, DOI 10.1002/cncr.29534
  158. Masi G, 2015, ANN ONCOL, V26, P724, DOI 10.1093/annonc/mdv012
  159. Masi G, 2010, LANCET ONCOL, V11, P845, DOI 10.1016/S1470-2045(10)70175-3
  160. Maughan TS, 2011, LANCET, V377, P2103, DOI 10.1016/S0140-6736(11)60613-2
  161. Maughan TS, 2003, LANCET, V361, P457, DOI 10.1016/S0140-6736(03)12461-0
  162. Mayer RJ, 2015, NEW ENGL J MED, V372, P1909, DOI 10.1056/NEJMoa1414325
  163. Romero AM, 2006, ACTA ONCOL, V45, P831, DOI 10.1080/02841860600897934
  164. Meulendijks D, 2015, LANCET ONCOL, V16, P1639, DOI 10.1016/S1470-2045(15)00286-7
  165. Misale S, 2014, CANCER DISCOV, V4, P1269, DOI 10.1158/2159-8290.CD-14-0462
  166. Misale S, 2012, NATURE, V486, P532, DOI 10.1038/nature11156
  167. Mitry E, 2008, J CLIN ONCOL, V26, P4906, DOI 10.1200/JCO.2008.17.3781
  168. Mohan S, 2014, PLOS GENET, V10, DOI 10.1371/journal.pgen.1004271
  169. Molinari F, 2009, BRIT J CANCER, V100, P1087, DOI 10.1038/sj.bjc.6604848
  170. Montagut C, 2012, NAT MED, V18, P221, DOI 10.1038/nm.2609
  171. Moosmann N, 2011, J CLIN ONCOL, V29, P1050, DOI 10.1200/JCO.2010.31.1936
  172. Moulton C, 2011, J CLIN ONCOL S, V29
  173. MOUTINHO C, 2014, J NATL CANC I, V0106
  174. Muller CI, 2008, INT J COLORECTAL DIS, V23, P1033, DOI 10.1007/s00384-008-0504-2
  175. Murtaza M, 2013, NATURE, V497, P108, DOI 10.1038/nature12065
  176. Neumeister VM, 2012, J NATL CANCER I, V104, P1815, DOI 10.1093/jnci/djs438
  177. Newman AM, 2014, NAT MED, V20, P552, DOI 10.1038/nm.3519
  178. Niekel MC, 2010, RADIOLOGY, V257, P674, DOI 10.1148/radiol.10100729
  179. Nopel-Dunnebacke S, 2014, Z GASTROENTEROL, V52, P1394, DOI 10.1055/s-0034-1366781
  180. Nordlinger B, 2009, ANN ONCOL, V20, P985, DOI 10.1093/annonc/mdn735
  181. Nordlinger B, 2013, LANCET ONCOL, V14, P1208, DOI 10.1016/S1470-2045(13)70447-9
  182. Nordlinger B, 2008, LANCET, V371, P1007, DOI 10.1016/S0140-6736(08)60455-9
  183. Nordlinger B, 2007, EUR J CANCER, V43, P2037, DOI 10.1016/j.ejca.2007.07.017
  184. Ogino S, 2014, ONCOGENE, V33, P2949, DOI 10.1038/onc.2013.244
  185. Ohrling K, 2008, ANTICANCER RES, V28, P1741
  186. Okines A, 2009, BRIT J CANCER, V101, P1033, DOI 10.1038/sj.bjc.6605259
  187. Olaussen KA, 2007, CURR OPIN PULM MED, V13, P284, DOI 10.1097/MCP.0b013e32816b5c63
  188. Oliveira C, 2007, ONCOGENE, V26, P158, DOI 10.1038/sj.onc.1209758
  189. Orlandi A, 2015, J CANCER, V6, P70, DOI 10.7150/jca.10478
  190. OUDEJANS JJ, 1991, INT J CANCER, V49, P875, DOI 10.1002/ijc.2910490613
  191. Papamichael D, 2015, ANN ONCOL, V26, P463, DOI 10.1093/annonc/mdu253
  192. Passardi A, 2015, ANN ONCOL, V26, P1201, DOI 10.1093/annonc/mdv130
  193. Peeters M, 2013, CLIN CANCER RES, V19, P1902, DOI 10.1158/1078-0432.CCR-12-1913
  194. Peeters M, 2010, J CLIN ONCOL, V28, P4706, DOI 10.1200/JCO.2009.27.6055
  195. Peeters M, 2015, CLIN CANCER RES, V21, P5469, DOI 10.1158/1078-0432.CCR-15-0526
  196. Perrone F, 2009, ANN ONCOL, V20, P84, DOI 10.1093/annonc/mdn541
  197. Peters GJ, 2002, BBA-MOL BASIS DIS, V1587, P194, DOI 10.1016/S0925-4439(02)00082-0
  198. Peters N, 2008, STRAHLENTHER ONKOL, V184, P296, DOI 10.1007/s00066-008-1718-5
  199. Petersen Rasmus K, 2014, Am J Nucl Med Mol Imaging, V4, P471
  200. Petre EN, 2013, CLIN COLORECTAL CANC, V12, P37, DOI [10.1016/j.clcc.2012.07.003, 10.1016/clcc.2012.07.003]
  201. Piessevaux H, 2009, ANN ONCOL, V20, P1375, DOI 10.1093/annonc/mdp011
  202. Piessevaux H, 2013, J CLIN ONCOL, V31, P3764, DOI 10.1200/JCO.2012.42.8532
  203. Pietrantonio F, 2015, EUR J CANCER, V51, P587, DOI 10.1016/j.ejca.2015.01.054
  204. Portier BP, 2013, MODERN PATHOL, V26, P1, DOI 10.1038/modpathol.2012.123
  205. Poulin-Costello M, 2013, TARGET ONCOL, V8, P127, DOI 10.1007/s11523-013-0271-z
  206. Prada-Villaverde A, 2014, J SURG ONCOL, V110, P779, DOI 10.1002/jso.23728
  207. Prades J, 2014, FUTURE ONCOL, V10, P1995, DOI [10.2217/fon.14.125, 10.2217/FON.14.125]
  208. Prades J, 2015, HEALTH POLICY, V119, P464, DOI 10.1016/j.healthpol.2014.09.006
  209. Prahallad A, 2012, NATURE, V483, P100, DOI 10.1038/nature10868
  210. Prenen H, 2009, CLIN CANCER RES, V15, P3184, DOI 10.1158/1078-0432.CCR-08-2961
  211. Price TJ, 2014, LANCET ONCOL, V15, P569, DOI 10.1016/S1470-2045(14)70118-4
  212. Price TJ, 2012, ASIA-PAC J CLIN ONCO, V8, P10, DOI 10.1111/j.1743-7563.2011.01458.x
  213. Primrose J, 2014, LANCET ONCOL, V15, P601, DOI 10.1016/S1470-2045(14)70105-6
  214. Punnoose EA, 2012, CLIN CANCER RES, V18, P2391, DOI 10.1158/1078-0432.CCR-11-3148
  215. Qian YY, 2014, ASIAN PAC J CANCER P, V15, P8383, DOI 10.7314/APJCP.2014.15.19.8383
  216. Ricke J, 2010, INT J RADIAT ONCOL, V78, P479, DOI 10.1016/j.ijrobp.2009.09.026
  217. Rivera F, 2015, ANN ONCOL S4, V26
  218. Rougier P, 2002, ANN ONCOL, V13, P1558, DOI 10.1093/annonc/mdf259
  219. Rougier P, 1998, LANCET, V352, P1407, DOI 10.1016/S0140-6736(98)03085-2
  220. Rowland A, 2015, BRIT J CANCER, V112, P1888, DOI 10.1038/bjc.2015.173
  221. Ruers T, 2012, ANN ONCOL, V23, P2619, DOI 10.1093/annonc/mds053
  222. Ruers T, 2015, J CLIN ONCOL S, V33, P3501
  223. Rusthoven KE, 2009, J CLIN ONCOL, V27, P1572, DOI 10.1200/JCO.2008.19.6329
  224. Saltz LB, 2008, J CLIN ONCOL, V26, P2013, DOI 10.1200/JCO.2007.14.9930
  225. Sanoff Hanna K, 2008, Semin Colon Rectal Surg, V19, P226, DOI 10.1053/j.scrs.2008.09.007
  226. Santini D, 2008, ONCOLOGIST, V13, P1270, DOI 10.1634/theoncologist.2008-0181
  227. Sartore-Bianchi A, 2009, CANCER RES, V69, P1851, DOI 10.1158/0008-5472.CAN-08-2466
  228. Schlijper RCJ, 2014, CANCER TREAT REV, V40, P60, DOI 10.1016/j.ctrv.2013.05.004
  229. Schmiegel W, 2013, ANN ONCOL, V24, P1580, DOI 10.1093/annonc/mdt028
  230. Schmoll HJ, 2012, ANN ONCOL, V23, P2479, DOI 10.1093/annonc/mds236
  231. Schwartzberg LS, 2014, J CLIN ONCOL, V32, P2240, DOI 10.1200/JCO.2013.53.2473
  232. Schwarzenbach H, 2011, NAT REV CANCER, V11, P426, DOI 10.1038/nrc3066
  233. Scorsetti M, 2013, INT J RADIAT ONCOL, V86, P336, DOI 10.1016/j.ijrobp.2012.12.021
  234. Seymour MT, 2013, LANCET ONCOL, V14, P749, DOI 10.1016/S1470-2045(13)70163-3
  235. Seymour MT, 2007, LANCET, V370, P143, DOI 10.1016/S0140-6736(07)61087-3
  236. Shah S, 2014, SURG ENDOSC, V28, P2783, DOI 10.1007/s00464-014-3545-3
  237. Siena S, 2015, J CLIN ONCOL, V33
  238. Simkens LHJ, 2015, LANCET, V385, P1843, DOI 10.1016/S0140-6736(14)62004-3
  239. Siravegna G, 2014, GENOME BIOL, V15, DOI 10.1186/s13059-014-0449-4
  240. Sobrero AF, 2008, J CLIN ONCOL, V26, P2311, DOI 10.1200/JCO.2007.13.1193
  241. Soria JC, 2007, J CLIN ONCOL, V25, P2648, DOI 10.1200/JCO.2007.11.3167
  242. Sorich MJ, 2015, ANN ONCOL, V26, P13, DOI 10.1093/annonc/mdu378
  243. Sosman JA, 2012, NEW ENGL J MED, V366, P707, DOI 10.1056/NEJMoa1112302
  244. Souglakos J, 2012, BRIT J CANCER, V106, P453, DOI 10.1038/bjc.2011.594
  245. Souglakos J, 2006, BRIT J CANCER, V94, P798, DOI 10.1038/sj.bjc.6603011
  246. Spindler KLG, 2009, ANN ONCOL, V20, P879, DOI 10.1093/annonc/mdn712
  247. Stein A, 2015, BRIT J CANCER, V113, P872, DOI 10.1038/bjc.2015.299
  248. Sterzing F, 2014, STRAHLENTHER ONKOL, V190, P872, DOI 10.1007/s00066-014-0714-1
  249. Stintzing S, 2014, ANN ONCOL S, V32, P445
  250. Stintzing S, 2013, EUR J CANCER, V49, pS8
  251. Stintzing S, 2014, ANN ONCOL S5, V25
  252. SUCHY B, 1992, INT J CANCER, V52, P30, DOI 10.1002/ijc.2910520107
  253. Swain SM, 2015, NEW ENGL J MED, V372, P724, DOI 10.1056/NEJMoa1413513
  254. Tabernero J, 2014, EUR J CANCER, V50, P320, DOI 10.1016/j.ejca.2013.09.013
  255. Tabernero J, 2015, LANCET ONCOL, V16, P499, DOI 10.1016/S1470-2045(15)70127-0
  256. Tack V, 2015, ONCOLOGIST, V20, P257, DOI 10.1634/theoncologist.2014-0382
  257. Taly V, 2013, CLIN CHEM, V59, P1722, DOI 10.1373/clinchem.2013.206359
  258. Taniguchi K, 2011, CLIN CANCER RES, V17, P7808, DOI 10.1158/1078-0432.CCR-11-1712
  259. Tanis E, 2014, EUR J CANCER, V50, P912, DOI 10.1016/j.ejca.2013.12.008
  260. Tebbutt NC, 2010, J CLIN ONCOL, V28, P3191, DOI 10.1200/JCO.2009.27.7723
  261. Thierry AR, 2014, NAT MED, V20, P430, DOI 10.1038/nm.3511
  262. Tian S, 2013, GUT, V62, P540, DOI 10.1136/gutjnl-2012-302423
  263. Tol J, 2009, NEW ENGL J MED, V361, P98, DOI 10.1056/NEJMc0904160
  264. Tol J, 2010, J CELL MOL MED, V14, P2122, DOI 10.1111/j.1582-4934.2009.00788.x
  265. Tomlinson JS, 2007, J CLIN ONCOL, V25, P4575, DOI 10.1200/JCO.2007.11.0833
  266. Tournigand C, 2004, J CLIN ONCOL, V22, P229, DOI 10.1200/JCO.2004.05.113
  267. Tournigand C, 2006, J CLIN ONCOL, V24, P394, DOI 10.1200/JCO.2005.03.0106
  268. Tournigand C, 2015, LANCET ONCOL, V16, P1493, DOI 10.1016/S1470-2045(15)00216-8
  269. Tran B, 2011, CANCER-AM CANCER SOC, V117, P4623, DOI 10.1002/cncr.26086
  270. Tselis N, 2011, J THORAC ONCOL, V6, P545, DOI 10.1097/JTO.0b013e318208c7a3
  271. Tsiatis AC, 2010, J MOL DIAGN, V12, P425, DOI 10.2353/jmoldx.2010.090188
  272. Turaga K, 2014, ANN SURG ONCOL, V21, P1501, DOI 10.1245/s10434-013-3061-z
  273. Tveit KM, 2012, J CLIN ONCOL, V30, P1755, DOI 10.1200/JCO.2011.38.0915
  274. Valtorta E, 2013, INT J CANCER, V133, P1259, DOI 10.1002/ijc.28106
  275. Van Cutsem E, 2009, ANN ONCOL, V20, P1842, DOI 10.1093/annonc/mdp233
  276. Van Cutsem E, 2004, BRIT J CANCER, V90, P1190, DOI 10.1038/sj.bjc.6601676
  277. Van Cutsem E, 2014, ANN ONCOL, V25, P1, DOI 10.1093/annonc/mdu260
  278. Van Cutsem E, 2011, J CLIN ONCOL, V29, P2011, DOI 10.1200/JCO.2010.33.5091
  279. Van Cutsem E, 2015, J CLIN ONCOL, V33, P692, DOI 10.1200/JCO.2014.59.4812
  280. Van Cutsem E, 2006, EUR J CANCER, V42, P2212, DOI 10.1016/j.ejca.2006.04.012
  281. Van Cutsem E, 2009, NEW ENGL J MED, V360, P1408, DOI 10.1056/NEJMoa0805019
  282. Van Cutsem E, 2012, J CLIN ONCOL, V30, P3499, DOI 10.1200/JCO.2012.42.8201
  283. van Hazel GA, 2016, J CLIN ONCOL, V34, P1723, DOI 10.1200/JCO.2015.66.1181
  284. van Krieken JHJM, 2008, VIRCHOWS ARCH, V453, P417, DOI 10.1007/s00428-008-0665-y
  285. Vaughn CP, 2011, GENE CHROMOSOME CANC, V50, P307, DOI 10.1002/gcc.20854
  286. Venderbosch S, 2014, CLIN CANCER RES, V20, P5322, DOI 10.1158/1078-0432.CCR-14-0332
  287. Venook AP, 2014, J CLIN ONCOL S, V32
  288. Wada H, 2004, INT J RADIAT ONCOL, V58, P1114, DOI 10.1016/j.ijrobp.2003.08.012
  289. Wanebo HJ, 2004, ANN SURG, V240, P657
  290. Wasan H, 2014, LANCET ONCOL, V15, P631, DOI 10.1016/S1470-2045(14)70106-8
  291. Weber JC, 2007, INT J CANCER, V120, P524, DOI 10.1002/ijc.22343
  292. Weiser MR, 2013, ONCOLOGY-NY, V27, P1074
  293. Wong NACS, 2014, J CLIN PATHOL, V67, P751, DOI 10.1136/jclinpath-2014-202467
  294. Wong R, 2011, ANN ONCOL, V22, P2042, DOI 10.1093/annonc/mdq714
  295. Wulf J, 2006, ACTA ONCOL, V45, P838, DOI 10.1080/02841860600904821
  296. Yaeger R, 2014, CANCER-AM CANCER SOC, V120, P2316, DOI 10.1002/cncr.28729
  297. Yamazaki K, 2014, ASCO M, V32, P3534
  298. Ye LC, 2013, J CLIN ONCOL, V31, P1931, DOI 10.1200/JCO.2012.44.8308
  299. Yonesaka K, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3002442
  300. Yoshino T, 2012, LANCET ONCOL, V13, P993, DOI 10.1016/S1470-2045(12)70345-5
  301. Zauber P, 2003, J CLIN PATHOL-MOL PA, V56, P137
  302. Zech CJ, 2014, BRIT J SURG, V101, P613, DOI 10.1002/bjs.9465
  303. Zorzi D, 2007, BRIT J SURG, V94, P274, DOI 10.1002/bjs.5719