Differential Associations of Specific Selective Serotonin Reuptake Inhibitors With Resting-State Heart Rate and Heart Rate Variability: Implications for Health and Well-Being
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Citações na Scopus
29
Tipo de produção
article
Data de publicação
2016
Editora
LIPPINCOTT WILLIAMS & WILKINS
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Título do Volume
Autores
KEMP, Andrew H.
NUNES, Maria A.
DANTAS, Eduardo M.
ANDREAO, Rodrigo V.
MILL, Jose G.
RIBEIRO, Antonio L. P.
KOENIG, Julian
Autor de Grupo de pesquisa
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Organizadores
Citação
PSYCHOSOMATIC MEDICINE, v.78, n.7, p.810-818, 2016
Resumo
Objective Debate has focused on the effects of the selective serotonin reuptake inhibitor (SSRI) antidepressants on heart rate (HR) and HR variability (HRV), both of which are predictors of adverse cardiovascular events. Here, we examine the associations between specific SSRI antidepressants and resting state HR (and HRV) after accounting for a host of potential confounding factors using propensity score techniques. Methods Participants included 10,466 not taking antidepressants, 46 participants taking escitalopram, 86 taking citalopram, 66 taking fluoxetine, 103 taking paroxetine, and 139 taking sertraline. HR and HRV (root mean square of successive squared differences, high frequency) were extracted from 10-minute resting-state ECGs. Analyses including propensity score weighting and matching were conducted using R-statistics to control for potentially confounding variables. Results Major findings indicated that users of all SSRI medicationsexcept fluoxetinedisplayed lower HRV relative to nonusers. Users of paroxetine also displayed significantly lower HRV relative to users of citalopram (Cohen's d = 0.42), fluoxetine (Cohen's d = 0.54), and sertraline (Cohen's d = 0.35), but not escitalopram. Although associations were also observed for HR, these were less robust than those for HRV. Conclusions Although paroxetine is associated with decreases in HRV relative to nonusers, as well as users of other SSRI medications, fluoxetine was the only medication not to display significant alterations in HR or HRV. These conclusions are limited by the cross-sectional design and nonrandomized nature of medication prescriptions. Findings highlight the importance of focusing on specific medications, rather than more heterogeneous groupings according to antidepressant action, and may have implications for health and well-being for the longer term.
Palavras-chave
health, heart rate variability, HRV, selective serotonin reuptake inhibitors, SSRIs, well-being
Referências
- Aquino EML, 2012, AM J EPIDEMIOL, V175, P315, DOI 10.1093/aje/kwr294
- Brunoni AR, 2013, J AFFECT DISORDERS, V151, P71, DOI 10.1016/j.jad.2013.05.054
- Brunoni AR, 2012, BIOL PSYCHIAT, V71, pE27, DOI 10.1016/j.biopsych.2011.08.026
- Brunoni AR, 2013, INT J NEUROPSYCHOPH, V16, P1937, DOI 10.1017/S1461145713000497
- Cacioppo JT, 2007, HANDBOOK OF PSYCHOPHYSIOLOGY, 3RD EDITION, P1, DOI 10.2277/ 0521844711
- Chalmers John A, 2014, Front Psychiatry, V5, P80, DOI 10.3389/fpsyt.2014.00080
- Chang JS, 2012, PROG NEURO-PSYCHOPH, V39, P136, DOI 10.1016/j.pnpbp.2012.06.002
- Cohen J., 1988, STAT POWER ANAL BEHA
- COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
- Colquhoun DM, 2013, MED J AUSTRALIA, V198, P483, DOI 10.5694/mja13.10153
- Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
- Ho DE, 2011, J STAT SOFTW, V42, P1
- Glassman AH, 2002, JAMA-J AM MED ASSOC, V288, P701, DOI 10.1001/jama.288.6.701
- Hamer M, 2011, EUR HEART J, V32, P437, DOI 10.1093/eurheartj/ehq438
- Jordan D, 2005, EXP PHYSIOL, V90, P175, DOI 10.1113/expphysiol.2004.029058
- Kemp AH, 2013, INT J PSYCHOPHYSIOL, V89, P288, DOI 10.1016/j.ijpsycho.2013.06.018
- Kemp AH, 2010, BIOL PSYCHIAT, V67, P1067, DOI 10.1016/j.biopsych.2009.12.012
- Kemp AH, 2014, FRONT PSYCHOL, V5, DOI 10.3389/fpsyg.2014.01387
- Kemp AH, 2014, PSYCHOPHARMACOLOGY, V231, P2281, DOI 10.1007/s00213-013-3374-4
- Kemp AH, 2014, AM J PSYCHIAT, V171, P1328, DOI 10.1176/appi.ajp.2014.13121605
- Kemp Andrew H, 2015, Front Public Health, V3, P9, DOI 10.3389/fpubh.2015.00009
- Kemp AH, 2011, BIOL PSYCHIAT, V69, pE25, DOI 10.1016/j.biopsych.2010.10.035
- Lederbogen F, 2001, J CLIN PSYCHOPHARM, V21, P238, DOI 10.1097/00004714-200104000-00018
- LEWIS G, 1992, PSYCHOL MED, V22, P465
- Licht CMM, 2010, BIOL PSYCHIAT, V68, P861, DOI 10.1016/j.biopsych.2010.06.032
- Licht CMM, 2011, BIOL PSYCHIAT, V69, pE27, DOI 10.1016/j.biopsych.2010.12.039
- Licht CMM, 2008, ARCH GEN PSYCHIAT, V65, P1358, DOI 10.1001/archpsyc.65.12.1358
- Lipsey M, 2001, PRACTICAL METAANALYS
- Magni LR, 2013, COCHRANE DB SYST REV, V7
- Mavrides N, 2013, DEPRESS ANXIETY, V30, P328, DOI 10.1002/da.22051
- McCaffrey DF, 2013, STAT MED, V32, P3388, DOI 10.1002/sim.5753
- Mill JG, 2013, REV SAUDE PUBL, V47, P54, DOI 10.1590/S0034-8910.2013047003851
- Nunes MA, 2012, REV HCPA, V31, P487
- Pacher P, 2004, CURR PHARM DESIGN, V10, P2463, DOI 10.2174/1381612043383872
- Pacher P, 1999, CURR MED CHEM, V6, P469
- Paraskevaidis Ioannis, 2012, Cardiovasc Hematol Agents Med Chem, V10, P109
- del Paso GAR, 2013, PSYCHOPHYSIOLOGY, V50, P477, DOI 10.1111/psyp.12027
- Ribeiro AL, 2013, REV SAUDE PUBL, V47, P87, DOI 10.1590/S0034-8910.2013047004406
- Richelson E, 2003, J CLIN PSYCHIAT, V64, P5
- Richelson E, 1996, J CLIN PSYCHOPHARM, V16, pS7, DOI 10.1097/00004714-199606002-00002
- Roose SP, 1998, AM J PSYCHIAT, V155, P660
- Sanchez C, 2014, INT CLIN PSYCHOPHARM, V29, P185, DOI 10.1097/YIC.0000000000000023
- Saul J., 1990, PHYSIOLOGY, V5, P32
- Schmidt MI, 2015, INT J EPIDEMIOL, V44, P68, DOI 10.1093/ije/dyu027
- Smoller JW, 2009, ARCH INTERN MED, V169, P2128, DOI 10.1001/archinternmed.2009.436
- Thayer JF, 2006, ANN NY ACAD SCI, V1088, P361, DOI 10.1196/annals.1366.014
- Thayer JF, 2009, ANN BEHAV MED, V37, P141, DOI 10.1007/s12160-009-9101-z
- Thayer JF, 2010, INT J CARDIOL, V141, P122, DOI 10.1016/j.ijcard.2009.09.543
- Tracey KJ, 2002, NATURE, V420, P853, DOI 10.1038/nature01321
- van Zyl Louis T, 2008, Biopsychosoc Med, V2, P12, DOI 10.1186/1751-0759-2-12
- Whang W, 2009, J AM COLL CARDIOL, V53, P950, DOI 10.1016/j.jacc.2008.10.060
Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - HU
Artigos e Materiais de Revistas Científicas - LIM/20
Carregar mais Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - HU
Artigos e Materiais de Revistas Científicas - LIM/20