A new densovirus in cerebrospinal fluid from a case of anti-NMDA-receptor encephalitis

Show simple item record

dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author Tung Gia Phan
MESSACAR, Kevin
DOMINGUEZ, Samuel R.
COSTA, Antonio Charlys da FMUSP-HC
DENG, Xutao
DELWART, Eric
dc.date.issued 2016
dc.identifier.citation ARCHIVES OF VIROLOGY, v.161, n.11, p.3231-3235, 2016
dc.identifier.issn 0304-8608
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/17304
dc.description.abstract We characterized the genome of a densovirus, tentatively called human CSF-associated densovirus 1 (HuCSFDV1), in cerebrospinal fluid (CSF) from a human case of encephalitis with antibodies against the N-methyl D-aspartate receptor. The presence of the viral genome in CSF was independently confirmed. This virus, which is proposed to be a member of a new species in the genus Iteradensovirus of the subfamily Densovirinae, showed the typical two ORFs encoding nonstructural and structural proteins with low-level identities of 22 and 16 % to the closest known densovirus relative. No other eukaryotic viral sequences were detected using deep sequencing. The replication and pathogenicity in humans of this virus, which belongs to a viral subfamily whose members are only known to replicate in invertebrates, remain to be demonstrated. Alternative explanations for the detection of densovirus DNA in CSF are discussed.
dc.description.sponsorship · NHLBI Grant [R01 HL105770]
· NIH/NCATS Colorado CTSA Grant [UL1 TR001082]
dc.language.iso eng
dc.publisher SPRINGER WIEN
dc.relation.ispartof Archives of Virology
dc.rights restrictedAccess
dc.subject.other simplex virus-1 encephalitis; fecal samples reveals; metagenomic analysis; sequence; parvoviruses; organization; mosquitos; disease; genomes; binding
dc.title A new densovirus in cerebrospinal fluid from a case of anti-NMDA-receptor encephalitis
dc.type article
dc.rights.holder Copyright SPRINGER WIEN
dc.description.group LIM/46
dc.identifier.doi 10.1007/s00705-016-3002-9
dc.identifier.pmid 27522586
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author COSTA, Antonio Charlys da:IMT:
hcfmusp.author.external · Tung Gia Phan:Blood Syst Res Inst, San Francisco, CA 94118 USA; Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94118 USA
· MESSACAR, Kevin:Childrens Hosp Colorado, Aurora, CO USA; Univ Colorado, Sch Med, Aurora, CO USA
· DOMINGUEZ, Samuel R.:Childrens Hosp Colorado, Aurora, CO USA; Univ Colorado, Sch Med, Aurora, CO USA
· DENG, Xutao:Blood Syst Res Inst, San Francisco, CA 94118 USA
· DELWART, Eric:Blood Syst Res Inst, San Francisco, CA 94118 USA; Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94118 USA
hcfmusp.origem.id WOS:000385252100026
hcfmusp.origem.id 2-s2.0-84982126484
hcfmusp.publisher.city WIEN
hcfmusp.publisher.country AUSTRIA
hcfmusp.relation.reference · Armangue T, 2013, J PEDIATR-US, V162, P850, DOI 10.1016/j.jpeds.2012.10.011
· Bergoin M, 2000, CONTRIB MICROBIOL, V4, P12
· Carlson J, 2006, ADV VIRUS RES, V68, P361, DOI 10.1016/S0065-3527(06)38010-X
· Cotmore SF, 2014, ARCH VIROL, V159, P1239, DOI 10.1007/s00705-013-1914-1
· Dalmau J, 2008, LANCET NEUROL, V7, P1091, DOI 10.1016/S1474-4422(08)70224-2
· Dalmau J, 2007, ANN NEUROL, V61, P25, DOI 10.1002/ana.21050
· Fediere G, 2002, VIROLOGY, V292, P299, DOI 10.1006/viro.2001.1257
· Ge XY, 2012, J VIROL, V86, P4620, DOI 10.1128/JVI.06671-11
· Gilbert GJ, 2014, NEUROLOGY, V82, P2041, DOI 10.1212/01.wnl.0000450946.75616.32
· Gleichman AJ, 2012, J NEUROSCI, V32, P11082, DOI 10.1523/JNEUROSCI.0064-12.2012
· Hewson I, 2014, P NATL ACAD SCI USA, V111, P17278, DOI 10.1073/pnas.1416625111
· ILYINA TV, 1992, NUCLEIC ACIDS RES, V20, P3279, DOI 10.1093/nar/20.13.3279
· Leypoldt F, 2013, NEUROLOGY, V81, P1637, DOI 10.1212/WNL.0b013e3182a9f531
· Li LL, 2010, J VIROL, V84, P6955, DOI 10.1128/JVI.00501-10
· Liu HQ, 2011, J VIROL, V85, P9863, DOI 10.1128/JVI.00828-11
· Liu KY, 2011, J VIROL, V85, P10069, DOI 10.1128/JVI.00625-11
· Ng TFF, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020579
· Oh J, 2016, CELL, V165, P854, DOI 10.1016/j.cell.2016.04.008
· Shi CY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129845
· Sivaram A, 2009, INTERVIROLOGY, V52, P1, DOI 10.1159/000210044
· Suzuki Y, 2015, SCI REP-UK, V5, DOI 10.1038/srep12701
· Tamura K, 2013, MOL BIOL EVOL, V30, P2725, DOI 10.1093/molbev/mst197
· Phan TG, 2015, VIROLOGY, V482, P98, DOI 10.1016/j.virol.2015.03.011
· Venkatesan A, 2015, CURR NEUROL NEUROSCI, V15, DOI 10.1007/s11910-015-0529-1
· WALKER JE, 1982, EMBO J, V1, P945
· Wang JP, 2005, J GEN VIROL, V86, P2169, DOI 10.1099/vir.0.80898-0
· Wang M, 2006, GENE, V366, P219, DOI 10.1016/j.gene.2005.07.015
· Wickstrom R, 2014, EUR J PAEDIATR NEURO, V18, P543, DOI 10.1016/j.ejpn.2014.03.011
· Woo PCY, 2014, VIROLOGY, V471, P117, DOI 10.1016/j.virol.2014.09.020
· Xu PJ, 2012, J VIROL, V86, P10909, DOI 10.1128/JVI.01912-12
· Yu Q, 2014, GENOME ANNOUNCEMENTS, V2
· Zhou CL, 2015, VIROL J, V12, DOI 10.1186/s12985-015-0431-0
dc.description.index MEDLINE
dc.identifier.eissn 1432-8798
hcfmusp.citation.scopus 7
hcfmusp.citation.wos 5
hcfmusp.affiliation.country Brasil
hcfmusp.affiliation.country Estados Unidos


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace



Browse

My Account

Statistics