A new densovirus in cerebrospinal fluid from a case of anti-NMDA-receptor encephalitis

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author Tung Gia Phan
COSTA, Antonio Charlys da FMUSP-HC
DENG, Xutao
dc.date.issued 2016
dc.identifier.citation ARCHIVES OF VIROLOGY, v.161, n.11, p.3231-3235, 2016
dc.identifier.issn 0304-8608
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/17304
dc.description.abstract We characterized the genome of a densovirus, tentatively called human CSF-associated densovirus 1 (HuCSFDV1), in cerebrospinal fluid (CSF) from a human case of encephalitis with antibodies against the N-methyl D-aspartate receptor. The presence of the viral genome in CSF was independently confirmed. This virus, which is proposed to be a member of a new species in the genus Iteradensovirus of the subfamily Densovirinae, showed the typical two ORFs encoding nonstructural and structural proteins with low-level identities of 22 and 16 % to the closest known densovirus relative. No other eukaryotic viral sequences were detected using deep sequencing. The replication and pathogenicity in humans of this virus, which belongs to a viral subfamily whose members are only known to replicate in invertebrates, remain to be demonstrated. Alternative explanations for the detection of densovirus DNA in CSF are discussed.
dc.description.sponsorship · NHLBI Grant [R01 HL105770]
· NIH/NCATS Colorado CTSA Grant [UL1 TR001082]
dc.language.iso eng
dc.publisher SPRINGER WIEN
dc.relation.ispartof Archives of Virology
dc.rights restrictedAccess
dc.subject.other simplex virus-1 encephalitis; fecal samples reveals; metagenomic analysis; sequence; parvoviruses; organization; mosquitos; disease; genomes; binding
dc.title A new densovirus in cerebrospinal fluid from a case of anti-NMDA-receptor encephalitis
dc.type article
dc.rights.holder Copyright SPRINGER WIEN
dc.description.group LIM/46
dc.identifier.doi 10.1007/s00705-016-3002-9
dc.identifier.pmid 27522586
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author COSTA, Antonio Charlys da:IMT:
hcfmusp.author.external · Tung Gia Phan:Blood Syst Res Inst, San Francisco, CA 94118 USA; Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94118 USA
· MESSACAR, Kevin:Childrens Hosp Colorado, Aurora, CO USA; Univ Colorado, Sch Med, Aurora, CO USA
· DOMINGUEZ, Samuel R.:Childrens Hosp Colorado, Aurora, CO USA; Univ Colorado, Sch Med, Aurora, CO USA
· DENG, Xutao:Blood Syst Res Inst, San Francisco, CA 94118 USA
· DELWART, Eric:Blood Syst Res Inst, San Francisco, CA 94118 USA; Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94118 USA
hcfmusp.origem.id WOS:000385252100026
hcfmusp.origem.id 2-s2.0-84982126484
hcfmusp.publisher.city WIEN
hcfmusp.publisher.country AUSTRIA
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dc.description.index MEDLINE
dc.identifier.eissn 1432-8798
hcfmusp.citation.scopus 7
hcfmusp.citation.wos 5
hcfmusp.affiliation.country Brasil
hcfmusp.affiliation.country Estados Unidos

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