Insulin-like growth factor 1 gene (CA)n repeats and a variable number of tandem repeats of the insulin gene in Brazilian children born small for gestational age

Show simple item record

dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author COLETTA, Rocio R. D. FMUSP-HC
JORGE, Alexander A. L. FMUSP-HC
ALVA, Catarina Brasil D'
PINTO, Emilia M.
BILLERBECK, Ana Elisa C.
PACHI, Paulo R.
LONGUI, Carlos A.
GARCIA, Ricardo M.
BOGUSZEWSKI, Margaret
ARNHOLD, Ivo J. P. FMUSP-HC
MENDONCA, Berenice B. FMUSP-HC
COSTA, Elaine M. F. FMUSP-HC
dc.date.issued 2013
dc.identifier.citation CLINICS, v.68, n.6, p.785-791, 2013
dc.identifier.issn 1807-5932
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/1777
dc.description.abstract OBJECTIVE: To investigate the influence of (CA)n repeats in the insulin-like growth factor 1 gene and a variable number of tandem repeats of the insulin gene on birth size in children who are small or adequate-sized for gestational age and to correlate these polymorphisms with serum insulin-like growth factor 1 levels and insulin sensitivity in children who are small for gestational age, with and without catch-up growth. PATIENTS AND METHODS: We evaluated 439 infants: 297 that were adequate-sized for gestational age and 142 that were small for gestational age (66 with and 76 without catch-up). The number of (CA) n repeat in the insulin-like growth factor 1 gene and a variable number of tandem repeats in the insulin gene were analyzed using GENESCAN software and polymerase chain reaction followed by enzymatic digestion, respectively. Clinical and laboratory data were obtained from all patients. RESULTS: The height, body mass index, paternal height, target height and insulin-like growth factor 1 serum levels were higher in children who were small for gestational age with catch-up. There was no difference in the allelic and genotypic distributions of both polymorphisms between the adequate-sized and small infants or among small infants with and without catch-up. Similarly, the polymorphisms were not associated with clinical or laboratory variables. CONCLUSION: Polymorphisms of the (CA) n repeats of the insulin-like growth factor 1 gene and a variable number of tandem repeats of the insulin gene, separately or in combination, did not influence pre- or postnatal growth, insulin-like growth factor 1 serum levels or insulin resistance.
dc.description.sponsorship · Fundacao de Amparo a Pesquisa do Estado de Sao Paulo - FAPESP [05/50093-9, 05/04726-0]
· Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) [301246/1995-5, 300982/2009-7, 306000/2004-0, 301477/2009-4]
· Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES): PRODOC [00031/03-8]
dc.language.iso eng
dc.publisher HOSPITAL CLINICAS, UNIV SAO PAULO
dc.relation.ispartof Clinics
dc.rights openAccess
dc.subject IGF1 Gene; Small For Gestational Age; Serum IGF1 Levels; IGF1 Polymorphism; VNTR of the Insulin Gene; Growth
dc.subject.other igf-i gene; low-birth-weight; catch-up growth; ins-vntr locus; intrauterine growth; glucose-tolerance; postnatal-growth; fetal-growth; generation-r; prospective cohort
dc.title Insulin-like growth factor 1 gene (CA)n repeats and a variable number of tandem repeats of the insulin gene in Brazilian children born small for gestational age
dc.type article
dc.rights.holder Copyright HOSPITAL CLINICAS, UNIV SAO PAULO
dc.description.group LIM/42
dc.description.group LIM/25
dc.identifier.doi 10.6061/clinics/2013(06)10
dc.identifier.pmid 23778474
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author COLETTA, Rocio R. D.:HC:ICHC
hcfmusp.author JORGE, Alexander A. L.:FM:MCM
hcfmusp.author ARNHOLD, Ivo J. P.:HC:ICHC
hcfmusp.author MENDONCA, Berenice B.:FM:MCM
hcfmusp.author COSTA, Elaine M. F.:HC:LIM/42
hcfmusp.author.external · ALVA, Catarina Brasil D':Univ Sao Paulo, Fac Med, Hosp Clin, Unidade Endocrinol Desenvolvimento,Lab Hormonios, Sao Paulo, Brazil
· PINTO, Emilia M.:Univ Sao Paulo, Fac Med, Hosp Clin, Unidade Endocrinol Desenvolvimento,Lab Hormonios, Sao Paulo, Brazil
· BILLERBECK, Ana Elisa C.:Univ Sao Paulo, Fac Med, Hosp Clin, Unidade Endocrinol Desenvolvimento,Lab Hormonios, Sao Paulo, Brazil
· PACHI, Paulo R.:Santa Casa Sao Paulo, Sao Paulo, Brazil
· LONGUI, Carlos A.:Santa Casa Misericordia Sao Paulo, Unidade Endocrinol Pediatr, Sao Paulo, Brazil
· GARCIA, Ricardo M.:Santa Casa Misericordia Sao Paulo, Unidade Endocrinol Pediatr, Sao Paulo, Brazil
· BOGUSZEWSKI, Margaret:Hosp Clin Curitiba, Unidade Endocrinol Pediatr, Curitiba, PR, Brazil
hcfmusp.origem.id WOS:000320463800010
hcfmusp.origem.id 2-s2.0-84879283327
hcfmusp.origem.id SCIELO:S1807-59322013000600785
hcfmusp.publisher.city SAO PAULO
hcfmusp.publisher.country BRAZIL
hcfmusp.relation.reference · Allen NE, 2002, CANCER EPIDEM BIOMAR, V11, P319
· Arends N, 2002, J CLIN ENDOCR METAB, V87, P2720, DOI 10.1210/jc.87.6.2720
· BELL GI, 1982, NATURE, V295, P31, DOI 10.1038/295031a0
· Bennett AJ, 2004, DIABETES, V53, P2126, DOI 10.2337/diabetes.53.8.2126
· CLIVER SP, 1995, OBSTET GYNECOL, V85, P625, DOI 10.1016/0029-7844(94)00437-I
· DAUGHADAY WH, 1989, ENDOCR REV, V10, P68
· Dunger DB, 1998, NAT GENET, V19, P98, DOI 10.1038/ng0598-98
· Elmlinger MW, 2004, CLIN CHEM LAB MED, V42, P654, DOI 10.1515/CCLM.2004.112
· Ester WA, 2009, HORM RES, V72, P15, DOI 10.1159/000224336
· Flanagan DE, 2000, AM J PHYSIOL-ENDOC M, V278, P700
· Frayling TM, 2002, DIABETES, V51, P2313, DOI 10.2337/diabetes.51.7.2313
· FREEMAN JV, 1995, ARCH DIS CHILD, V73, P17
· Geelhoed JJM, 2008, CLIN ENDOCRINOL, V68, P382, DOI 10.1111/j.1365-2265.2007.03050.x
· GIUDICE LC, 1995, J CLIN ENDOCR METAB, V80, P1548, DOI 10.1210/jc.80.5.1548
· Gluckman P D, 1997, Acta Paediatr Suppl, V422, P69
· Harrela M, 1996, J CLIN INVEST, V98, P2612, DOI 10.1172/JCI119081
· HEMMILA I, 1984, ANAL BIOCHEM, V137, P335, DOI 10.1016/0003-2697(84)90095-2
· Ibanez L, 2001, J CLIN ENDOCR METAB, V86, P5788, DOI 10.1210/jc.86.12.5788
· Iniguez G, 2006, J CLIN ENDOCR METAB, V91, P4645, DOI 10.1210/jc.2006-0844
· Ioannidis JPA, 2001, NAT GENET, V29, P306, DOI 10.1038/ng749
· Jaquet D, 2000, J CLIN ENDOCR METAB, V85, P1401, DOI 10.1210/jc.85.4.1401
· Johnston LB, 2003, J CLIN ENDOCR METAB, V88, P4805, DOI 10.1210/jc.2003-030563
· LASSARRE C, 1991, PEDIATR RES, V29, P219, DOI 10.1203/00006450-199103000-00001
· Leger J, 1996, PEDIATR RES, V40, P101, DOI 10.1203/00006450-199607000-00018
· Lindsay RS, 2003, DIABETES, V52, P187, DOI 10.2337/diabetes.52.1.187
· LIU JP, 1993, CELL, V75, P59, DOI 10.1016/S0092-8674(05)80084-4
· Maas JAJBM, 2010, HORM RES PAEDIAT, V73, P120, DOI 10.1159/000277631
· Man PL, 1997, J CLIN ENDOCR METAB, V82, P402
· MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
· Missmer SA, 2002, INT J CANCER, V100, P332, DOI 10.1002/ijc.10473
· Mitchell SMS, 2004, J CLIN ENDOCR METAB, V89, P310, DOI 10.1210/jc.2003-030605
· Mook-Kanamori DO, 2007, EUR J ENDOCRINOL, V157, P741, DOI 10.1530/EJE-07-0378
· Netchine I, 2009, J CLIN ENDOCR METAB, V94, P3913, DOI 10.1210/jc.2009-0452
· Nielsen EMD, 2004, CLIN BIOCHEM, V37, P660, DOI 10.1016/j.clinbiochem.2004.03.014
· Ong KKL, 2000, BRIT MED J, V320, P967, DOI 10.1136/bmj.320.7240.967
· Ong KKL, 1999, NAT GENET, V21, P262
· Paquette J, 1998, J BIOL CHEM, V273, P14158, DOI 10.1074/jbc.273.23.14158
· Phillips DIW, 2000, HYPERTENSION, V35, P1301
· PHIPPS K, 1993, DIABETOLOGIA, V36, P225, DOI 10.1007/BF00399954
· Pringle PJ, 2005, J CLIN ENDOCR METAB, V90, P2556, DOI 10.1210/jc.2004-1674
· Redden DT, 2003, J NUTR, V133, P3323
· Rosen CJ, 1998, J CLIN ENDOCR METAB, V83, P2286, DOI 10.1210/jc.83.7.2286
· ROTWEIN P, 1986, J BIOL CHEM, V261, P4828
· Saenger P, 2007, ENDOCR REV, V28, P219, DOI 10.1210/er.2006-0039
· Shen H, 2005, J BONE MINER RES, V20, P365, DOI 10.1359/JBMR.041129
· SOINI E, 1983, CLIN CHEM, V29, P65
· Soto N, 2003, J CLIN ENDOCR METAB, V88, P3645, DOI 10.1210/jc.2002-030031
· TRINDER P, 1969, J CLIN PATHOL, V22, P246, DOI 10.1136/jcp.22.2.246-b
· Usher R, 1969, BIRTH WEIGHT GESTATI
· USHER R, 1969, J PEDIATR, V74, P901, DOI 10.1016/S0022-3476(69)80224-6
· Usher R, 1969, BIRTH LENGH
· Vaessen N, 2002, LANCET, V359, P1036, DOI 10.1016/S0140-6736(02)08067-4
· Vaessen N, 2001, DIABETES, V50, P637, DOI 10.2337/diabetes.50.3.637
· Veening MA, 2002, J CLIN ENDOCR METAB, V87, P4657, DOI 10.1210/jc.2001-011940
· Vu-Hong TA, 2006, J CLIN ENDOCR METAB, V91, P2437, DOI 10.1210/jc.2005-2245
· Walenkamp MJE, 2005, J CLIN ENDOCR METAB, V90, P2855, DOI 10.1210/jc.2004-1254
· Woods KA, 1996, NEW ENGL J MED, V335, P1363, DOI 10.1056/NEJM199610313351805
dc.description.index MEDLINE
hcfmusp.citation.scopus 2
hcfmusp.citation.wos 2
hcfmusp.affiliation.country Brasil


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace



Browse

My Account

Statistics