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https://observatorio.fm.usp.br/handle/OPI/17794
Title: | The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats |
Authors: | CAMARGO, Cristina Pires; FERNANDES, Felipe Alexandre; LEE, Michel Hyo Mi; SILVA, Luiza Campos Moreira; BESTEIRO, Julio Morais; GEMPERLI, Rolf |
Citation: | ACTA CIRURGICA BRASILEIRA, v.31, n.11, p.720-723, 2016 |
Abstract: | PURPOSE: To evaluate the effect of Botulinum Toxin A in different time of tobacco exposure. METHODS: 60 male, Wistar rats were divided into two tobacco exposure groups: a 2-month or a 4-month regimen. After this period, these two groups were subdivided as two: saline solution(SS) or botulinum toxin A(Bonta), at the time of the surgery. Seven days before the SS or Bonta injection, the animals were submitted to a random flap (3x10cm). On the seventh postoperative day, all animals were assessed for total flap area, viable area, and the viable/total area ratio. RESULTS: This study showed a difference between groups 2-month saline vs. BontA injection (p=0.04); groups 4-month saline vs. BontA injection (p=0.001); groups 2-month saline vs. 4-month BontA (p=0.003), and, between groups 2-month BontA vs. 4-month saline(p=0.03). CONCLUSIONS: Botulinum Toxin A increased random flap viability in tobacco-exposed rats. Two months of tobacco exposure had the same effect as exposure for four months. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCG Artigos e Materiais de Revistas Científicas - LIM/04 Artigos e Materiais de Revistas Científicas - LIM/05 Artigos e Materiais de Revistas Científicas - ODS/03 |
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art_CAMARGO_The_positive_effect_of_Botulinum_toxin_type_A_2016.PDF | publishedVersion (English) | 284.95 kB | Adobe PDF | View/Open |
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