Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis

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Arquivos
art_BOEDHOE_Distinct_Subcortical_Volume_Alterations_in_Pediatric_and_Adult_2017.PDF (575.69 KB)
Citações na Scopus
240
Tipo de produção
article
Data de publicação
2017
Editora
AMER PSYCHIATRIC PUBLISHING, INC
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
BOEDHOE, Premika S. W.
SCHMAAL, Lianne
ABE, Yoshinari
AMEIS, Stephanie H.
ARNOLD, Paul D.
BENEDETTI, Francesco
BEUCKE, Jan C.
BOLLETTINI, Irene
BOSE, Anushree
Autor de Grupo de pesquisa
ENIGMA OCD Working Grp
Editores
Coordenadores
Organizadores
Citação
AMERICAN JOURNAL OF PSYCHIATRY, v.174, n.1, p.60-69, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective: Structural brain imaging studies in obsessive compulsive disorder (OCD) have produced inconsistent findings. This may be partially due to limited statistical power from relatively small samples and clinical heterogeneity related to variation in illness profile and developmental stage. To address these limitations, the authors conducted meta and mega-analyses of data from OCD sites worldwide. Method: T-1 images from 1,830 OCD patients and 1,759 control subjects were analyzed, using coordinated and standardized processing, to identify subcortical brain volumes that differ between OCD patients and healthy subjects. The authors performed a meta analysis on the mean of the left and right hemisphere measures of each subcortical structure, and they performed a mega-analysis by pooling these volumetric measurements from each site. The authors additionally examined potential modulating effects of clinical characteristics on morphological differences in OCD patients. Results: The meta-analysis indicated that adult patients had significantly smaller hippocampal volumes (Cohen's d=-0.13; % difference=-2.80) and larger pallidum volumes (d=0.16; % difference=3.16) compared with adult controls. Both effects were stronger in medicated patients compared with controls (d=-0.29, % difference=-4.18, and d=0.29, % difference=4.38, respectively). Unmedicated pediatric patients had significantly larger thalamic volumes (d=0.38, % difference=3.08) compared with pediatric controls. None of these findings were mediated by sample characteristics, such as mean age or scanning field strength. The mega-analysis yielded similar results. Conclusions: The results indicate different patterns of sub cortical abnormalities in pediatric and adult OCD patients. The patlidum and hippocampus seem to be of importance in adult OCD, whereas the thalamus seems to be key in pediatric OCD. These findings highlight the potential importance of neurodevelopmental alterations in OCD and suggest that further research on neuroplasticity in OCD may be useful.
Palavras-chave
URI
https://observatorio.fm.usp.br/handle/OPI/18134
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Coleções
Artigos e Materiais de Revistas Científicas - LIM/21
Artigos e Materiais de Revistas Científicas - HC/InRad