Left ventricular area on non-contrast cardiac computed tomography as a predictor of incident heart failure The Multi-Ethnic Study of Atherosclerosis

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art_BITTENCOURT_Left_ventricular_area_on_noncontrast_cardiac_computed_tomography_2016.PDF (1.21 MB)
Citações na Scopus
10
Tipo de produção
article
Data de publicação
2016
Editora
ELSEVIER SCIENCE INC
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
BLANKSTEIN, Ron
MAO, Songshou
RIVERA, Juan J.
BERTONI, Alain G.
SHAW, Leslee J.
BLUMENTHAL, Roger S.
BUDOFF, Matthew J.
NASIR, Khurram
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
Journal of Cardiovascular Computed Tomography, v.10, n.6, p.500-506, 2016
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: The use of non-contrast cardiac computed tomography measurements to predict heart failure (HF) has not been studied. In the present study we evaluated the prognostic value of left ventricular area adjusted for the body surface area (LVA-BSA) measured by non-contrast cardiac CT to predict incident HF and cardiovascular disease (CVD) events. Methods: We studied left ventricular dimensions and calculated LVA-BSA in 6781 participants of the MESA study (mean age: was 62 +/- 10 years, 53% females; 62% non-white) free from prior HF who underwent non-contrast cardiac CT to evaluate the coronary artery calcium score (CAC) at baseline and were followed up for a median of 10.2 years. Results: During follow up, 237 (3.5%) incident HF and 475 (7.0%) CVD events occurred. After adjustment for clinical variables and CAC, LVA-BSA was significantly associated with incident HF (hazard ratio [HR]: 1.10 per 100 mm(2)/m(2), p < 0.001) and CVD events (HR: 1.07 per 100 mm(2)/m(2), p < 0.001). The area under the ROC curve for the prediction of incident HF improved from 0.787 on a model including only risk factors to 0.798 when CAC was added (p = 0.02), and to 0.816 with the additional inclusion of LVA-BSA (p = 0.007). Similar improvements for the prediction of CVD events were noted. Conclusion: In an ethnically diverse population of asymptomatic individuals free from baseline CVD or HF, the left ventricular area measured by non-contrast cardiac CT is a strong predictor of incident HF events beyond traditional risk factors and CAC score.
Palavras-chave
Non-contrast cardiac computed tomography, Left ventricle size, Heart failure, Prognosis
URI
https://observatorio.fm.usp.br/handle/OPI/18146
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Coleções
Artigos e Materiais de Revistas Científicas - HU
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - ODS/03