Left ventricular area on non-contrast cardiac computed tomography as a predictor of incident heart failure The Multi-Ethnic Study of Atherosclerosis

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author BITTENCOURT, Marcio Sommer FMUSP-HC
BLANKSTEIN, Ron
MAO, Songshou
RIVERA, Juan J.
BERTONI, Alain G.
SHAW, Leslee J.
BLUMENTHAL, Roger S.
BUDOFF, Matthew J.
NASIR, Khurram
dc.date.issued 2016
dc.identifier.citation Journal of Cardiovascular Computed Tomography, v.10, n.6, p.500-506, 2016
dc.identifier.issn 1934-5925
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/18146
dc.description.abstract Background: The use of non-contrast cardiac computed tomography measurements to predict heart failure (HF) has not been studied. In the present study we evaluated the prognostic value of left ventricular area adjusted for the body surface area (LVA-BSA) measured by non-contrast cardiac CT to predict incident HF and cardiovascular disease (CVD) events. Methods: We studied left ventricular dimensions and calculated LVA-BSA in 6781 participants of the MESA study (mean age: was 62 +/- 10 years, 53% females; 62% non-white) free from prior HF who underwent non-contrast cardiac CT to evaluate the coronary artery calcium score (CAC) at baseline and were followed up for a median of 10.2 years. Results: During follow up, 237 (3.5%) incident HF and 475 (7.0%) CVD events occurred. After adjustment for clinical variables and CAC, LVA-BSA was significantly associated with incident HF (hazard ratio [HR]: 1.10 per 100 mm(2)/m(2), p < 0.001) and CVD events (HR: 1.07 per 100 mm(2)/m(2), p < 0.001). The area under the ROC curve for the prediction of incident HF improved from 0.787 on a model including only risk factors to 0.798 when CAC was added (p = 0.02), and to 0.816 with the additional inclusion of LVA-BSA (p = 0.007). Similar improvements for the prediction of CVD events were noted. Conclusion: In an ethnically diverse population of asymptomatic individuals free from baseline CVD or HF, the left ventricular area measured by non-contrast cardiac CT is a strong predictor of incident HF events beyond traditional risk factors and CAC score.
dc.description.sponsorship · National Heart, Lung, and Blood Institute [N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC 95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC 95169]
· National Center for Research Resources [UL1-TR-000040, UL1 TR 001079, UL1-RR-025005]
· [R01 HL071739]
dc.language.iso eng
dc.publisher ELSEVIER SCIENCE INC
dc.relation.ispartof Journal of Cardiovascular Computed Tomography
dc.rights restrictedAccess
dc.subject Non-contrast cardiac computed tomography; Left ventricle size; Heart failure; Prognosis
dc.subject.other heinz nixdorf recall; general-population; cardiovascular events; association; disease; update; mass
dc.title Left ventricular area on non-contrast cardiac computed tomography as a predictor of incident heart failure The Multi-Ethnic Study of Atherosclerosis
dc.type article
dc.rights.holder Copyright ELSEVIER SCIENCE INC
dc.identifier.doi 10.1016/j.jcct.2016.07.009
dc.identifier.pmid 27499493
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author BITTENCOURT, Marcio Sommer:HU:SCPACEX-62
hcfmusp.author.external · BLANKSTEIN, Ron:Brigham & Womens Hosp, Dept Med, Div Cardiovasc, Noninvas Cardiovasc Imaging Program, Boston, MA USA; Brigham & Womens Hosp, Dept Radiol, Boston, MA USA; Harvard Med Sch, Boston, MA USA
· MAO, Songshou:Harbour UCLA, Los Angeles Biomed Res Inst, Div Cardiol, Torrance, CA USA
· RIVERA, Juan J.:Johns Hopkins Ciccarone Ctr Prevent Heart Dis, Baltimore, MD USA
· BERTONI, Alain G.:Wake Forest Univ, Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC USA
· SHAW, Leslee J.:Emory Univ, Sch Med, Dept Med, Emory Clin Cardiovasc Res Inst, Atlanta, GA 30322 USA
· BLUMENTHAL, Roger S.:Johns Hopkins Ciccarone Ctr Prevent Heart Dis, Baltimore, MD USA
· BUDOFF, Matthew J.:Harbour UCLA, Los Angeles Biomed Res Inst, Div Cardiol, Torrance, CA USA
· NASIR, Khurram:Johns Hopkins Ciccarone Ctr Prevent Heart Dis, Baltimore, MD USA; Baptist Hlth South Florida, Ctr Healthcare Adv & Outcomes, Miami, FL USA; Baptist Hlth South Florida, MCVI, Miami, FL USA; Florida Int Univ, Robert Stempel Coll Publ Hlth & Social Work, Herbert Wertheim Coll Med, Dept Med, Miami, FL 33199 USA; Florida Int Univ, Robert Stempel Coll Publ Hlth & Social Work, Dept Epidemiol, Miami, FL 33199 USA
hcfmusp.origem.id WOS:000389158600009
hcfmusp.origem.id 2-s2.0-84998865425
hcfmusp.publisher.city NEW YORK
hcfmusp.publisher.country USA
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dc.description.index MEDLINE
hcfmusp.citation.scopus 3
hcfmusp.citation.wos 4
hcfmusp.affiliation.country Brasil
hcfmusp.affiliation.country Estados Unidos


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