Evaluation of the efficacy of photodynamic therapy for the treatment of actinic cheilitis

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author CHAVES, Yuri N.
dc.date.issued 2017
dc.identifier.citation PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE, v.33, n.1, p.14-21, 2017
dc.identifier.issn 0905-4383
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/18812
dc.description.abstract IntroductionActinic cheilitis (AC) is a lip intraepithelial neoplasia, whose cells present alterations similar to those presented by invasive squamous cell carcinomas (SCCs). ObjectiveTo conduct clinical and laboratory evaluation by histopathology and immunohistochemistry of the efficacy of actinic cheilitis treatment using photodynamic therapy (PDT) with methyl aminolevulinate (MAL) and noncoherent red light. Materials and methodsPatients with actinic cheilitis detected by histopathological examination were submitted to two sessions of photodynamic therapy with a two-week interval between them. They were examined immediately after the sessions, four, six, and twelve weeks after beginning treatment when a new biopsy was carried out. Clinical histopathological and immunohistochemical parameters were evaluated before and after treatment. ResultsOf the 23 patients who underwent biopsy, 16 completed two photodynamic therapy sessions and the material of one patient was insufficient for immunohistochemistry. Complete clinical response was achieved in 62.5% (10 of 16 patients) and 37.5% still remained with clinical evidence of AC. In spite of this, no case of cure by histopathological analysis was found. There was no significant statistical change among the values of Ki-67, survivin, and p53 observed before and after treatment. ConclusionPhotodynamic therapy, as carried out in this trial, was not an efficacious therapeutic option for treating patients with actinic cheilitis included in this sample.
dc.language.iso eng
dc.publisher WILEY-BLACKWELL
dc.relation.ispartof Photodermatology Photoimmunology & Photomedicine
dc.rights restrictedAccess
dc.subject actinic cheilitis; immunohistochemistry; photodynamic therapy
dc.subject.other topical methyl aminolevulinate; 5-aminolevulinic acid; randomized multicenter; keratoses; cancer; survivin; scalp; trial; face
dc.title Evaluation of the efficacy of photodynamic therapy for the treatment of actinic cheilitis
dc.type article
dc.rights.holder Copyright WILEY-BLACKWELL
dc.description.group LIM/06
dc.description.group LIM/53
dc.identifier.doi 10.1111/phpp.12281
dc.identifier.pmid 27864997
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author TOREZAN, Luis Antonio:HC:ICHC
hcfmusp.author LOURENCO, Silvia Vanessa:HC:LIM/06
hcfmusp.author NETO, Cyro Festa:FM:MDT
hcfmusp.author.external · CHAVES, Yuri N.:Univ Sao Paulo, Dept Dermatol, Fac Med, Hosp Clin, Sao Paulo, SP, Brazil
hcfmusp.origem.id 2-s2.0-85010842088
hcfmusp.origem.id WOS:000394642900002
hcfmusp.publisher.city HOBOKEN
hcfmusp.publisher.country USA
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dc.description.index MEDLINE
dc.identifier.eissn 1600-0781
hcfmusp.citation.scopus 7
hcfmusp.citation.wos 7
hcfmusp.affiliation.country Brasil

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