Expression of PAR-4 and PHLDA1 is prognostic for overall and disease-free survival in oral squamous cell carcinomas

Imagem de Miniatura
Arquivos
art_NAGAI_Expression_of_PAR_4_and_PHLDA1_is_prognostic_2013.PDF (390.43 KB)
Citações na Scopus
18
Tipo de produção
article
Data de publicação
2013
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER
Autores
COUTINHO-CAMILLO, Claudia Malheiros
LOURENCO, Silvia Vanessa
NONOGAKI, Suely
VARTANIAN, Jose Guilherme
KOWALSKI, Luiz Paulo
SOARES, Fernando Augusto
Citação
VIRCHOWS ARCHIV, v.463, n.1, p.31-39, 2013
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
PAR-4 is a tumor suppressor protein with a pro-apoptotic function and down-regulation of PAR-4 is seen in a variety of tumors. PHLDA1 gene overexpression has been shown to reduce cell proliferation and induce cell death in a variety of cell types. In this study, 229 cases of oral squamous cell carcinoma (OSCC), arranged in a tissue microarray, were analyzed by immunohistochemistry. PAR-4 expression was predominantly moderate to strong and expression of PHLDA1 was predominantly negative or weak. Cytoplasmic expression of PAR-4 was associated with advanced clinical stage. Expression of PHLDA1 was associated with advanced clinical stage of the tumour. Five-year overall and disease-free survival rates differed significantly between cases that did and cases that did not express PHLDA1, and by multivariate analysis, expression of PHLDA1 and PAR-4 were independent prognostic factors in OSCC patients. Expression of PAR-4 and PHLDA1 is altered in OSCC and might be a valuable prognostic indicator for this disease.
Palavras-chave
Oral squamous cell carcinoma, Tissue microarray, Immunohistochemistry, PAR-4, PHLDA1
URI
https://observatorio.fm.usp.br/handle/OPI/1902
Referências
  1. Boehrer S, HEMATOL J, V2, P103
  2. Burikhanov R, 2009, CELL, V138, P377, DOI 10.1016/j.cell.2009.05.022
  3. Chaudhry P, 2012, MOL CELL BIOL, V32, P826, DOI 10.1128/MCB.06321-11
  4. Cook J, 1999, ONCOGENE, V18, P1205, DOI 10.1038/sj.onc.1202416
  5. Coutinho-Camillo CM, 2010, HISTOPATHOLOGY, V57, P304, DOI 10.1111/j.1365-2559.2010.03621.x
  6. Coutinho-Camillo CM, 2011, HEAD NECK-J SCI SPEC, V33, P1191, DOI 10.1002/hed.21602
  7. Frank D, 1999, MAMM GENOME, V10, P1150, DOI 10.1007/s003359901182
  8. Gomes I, 1999, J NEUROCHEM, V73, P612, DOI 10.1046/j.1471-4159.1999.0730612.x
  9. Goswami A, 2006, CANCER RES, V66, P2889, DOI 10.1158/0008-5472.CAN-05-4458
  10. Hanahan D, 2000, CELL, V100, P57, DOI 10.1016/S0092-8674(00)81683-9
  11. Hanahan D, 2011, CELL, V144, P646, DOI 10.1016/j.cell.2011.02.013
  12. Hossain GS, 2003, J BIOL CHEM, V278, P30317, DOI 10.1074/jbc.M212897200
  13. Johnson EO, 2011, J CELL SCI, V124, P2711, DOI 10.1242/jcs.084970
  14. Kogel D, 2001, BRIT J CANCER, V85, P1801, DOI 10.1054/bjoc.2001.2158
  15. Lee JW, 2010, HEAD NECK-J SCI SPEC, V32, P877, DOI 10.1002/hed.21282
  16. Massano J, 2006, ORAL SURG ORAL MED O, V102, P67, DOI 10.1016/j.tripleo.2005.07.038
  17. Moreno-Bueno G, 2007, CANCER RES, V67, P1927, DOI 10.1158/0008-5472.CAN-06-2687
  18. Nagai MA, 2010, INT J ONCOL, V37, P41, DOI 10.3892/ijo_00000651
  19. Nagai MA, 2007, BREAST CANCER RES TR, V106, P49, DOI 10.1007/s10549-006-9475-6
  20. Neef R, 2002, CANCER RES, V62, P5920
  21. Oberg HH, 2004, CELL DEATH DIFFER, V11, P674, DOI 10.1038/sj.cdd.4401407
  22. Oberst MD, 2008, BMC CANCER, V8, DOI 10.1186/1471-2407-8-189
  23. Ohyama M, 2006, J CLIN INVEST, V116, P249, DOI 10.1172/JCI26043
  24. Park CG, 1996, IMMUNITY, V4, P583, DOI 10.1016/S1074-7613(00)80484-7
  25. Qiu GF, 1999, ONCOGENE, V18, P623, DOI 10.1038/sj.onc.1202344
  26. Sakthianandeswaren A, 2011, CANCER RES, V71, P3709, DOI 10.1158/0008-5472.CAN-10-2342
  27. Saude M, 2011, ESTIMATIVA 2012 INCI
  28. Schoelch ML, 1999, ORAL ONCOL, V35, P77, DOI 10.1016/S1368-8375(98)00065-7
  29. Sellheyer K, 2011, J CUTAN PATHOL, V38, P542, DOI 10.1111/j.1600-0560.2011.01693.x
  30. Sellheyer K, 2011, J CUTAN PATHOL, V38, P460, DOI 10.1111/j.1600-0560.2010.01671.x
  31. Sharma AK, 2011, CLIN CANCER RES, V17, P4474, DOI 10.1158/1078-0432.CCR-10-2370
  32. Shrestha-Bhattarai T, 2010, ONCOGENE, V29, P3873, DOI 10.1038/onc.2010.141
  33. Siegel R, 2012, CA-CANCER J CLIN, V62, P10, DOI 10.3322/caac.20138
  34. Toyoshima Y, 2004, J BIOL CHEM, V279, P25898, DOI 10.1074/jbc.M400661200
  35. Zhao YM, 2008, CANCER BIOL THER, V7, P1867, DOI 10.4161/cbt.7.12.6945

Coleções
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - LIM/24
Artigos e Materiais de Revistas Científicas - ODS/03