Transmission between Archaic and Modern Human Ancestors during the Evolution of the Oncogenic Human Papillomavirus 16

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art_PIMENOFF_Transmission_between_Archaic_and_Modern_Human_Ancestors_during_2017.PDF (686.43 KB)
Citações na Scopus
66
Tipo de produção
article
Data de publicação
2017
Editora
OXFORD UNIV PRESS
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
PIMENOFF, Ville N.
BRAVO, Ignacio G.
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
MOLECULAR BIOLOGY AND EVOLUTION, v.34, n.1, p.4-19, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Every human suffers through life a number of papillomaviruses (PVs) infections, most of them asymptomatic. A notable exception are persistent infections by Human papillomavirus 16 (HPV16), the most oncogenic infectious agent for humans and responsible for most infection-driven anogenital cancers. Oncogenic potential is not homogeneous among HPV16 lineages, and genetic variation within HPV16 exhibits some geographic structure. However, an in-depth analysis of the HPV16 evolutionary history was still wanting. We have analyzed extant HPV16 diversity and compared the evolutionary and phylogeographical patterns of humans and of HPV16. We show that codivergence with modern humans explains at most 30% of the present viral geographical distribution. The most explanatory scenario suggests that ancestral HPV16 already infected ancestral human populations and that viral lineages co-diverged with the hosts in parallel with the split between archaic Neanderthal-Denisovans and ancestral modern human populations, generating the ancestral HPV16A and HPV16BCD viral lineages, respectively. We propose that after out-of-Africa migration of modern human ancestors, sexual transmission between human populations introduced HPV16A into modern human ancestor populations. We hypothesize that differential coevolution of HPV16 lineages with different but closely related ancestral human populations and subsequent host-switch events in parallel with introgression of archaic alleles into the genomes of modern human ancestors may be largely responsible for the present-day differential prevalence and association with cancers for HPV16 variants.
Palavras-chave
divergence, evolutionary medicine, Hominin evolution, host-switch, human papillomavirus, infection and cancer, sexually transmitted infection, variant, virus-host coevolution
URI
https://observatorio.fm.usp.br/handle/OPI/19150
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Coleções
Artigos e Materiais de Revistas Científicas - LIM/52
Artigos e Materiais de Revistas Científicas - ODS/03