White adipose tissue IFN-gamma expression and signalling along the progression of rodent cancer cachexia

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art_YAMASHITA_White_adipose_tissue_IFNgamma_expression_and_signalling_along_2017.PDF (380.33 KB)
Citações na Scopus
16
Tipo de produção
article
Data de publicação
2017
Editora
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
YAMASHITA, Alex Shimura
NEVES, Rodrigo Xavier das
ROSA-NETO, Jose Cesar
LIRA, Fabio dos Santos
BATISTA JR., Miguel Luis
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
CYTOKINE, v.89, Special Issue, p.122-126, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Cachexia is associated with increased morbidity and mortality in cancer. The White adipose tissue (WAT) synthesizes and releases several pro-inflammatory cytokines that play a role in cancer cachexia-related systemic inflammation. IFN-gamma is a pleiotropic cytokine that regulates several immune and metabolic functions. To assess whether IFN-gamma signalling in different WAT pads is modified along cancer-cachexia progression, we evaluated IFN-gamma receptors expression (IFNGR1 and IFNGR2) and IFN-gamma protein expression in a rodent model of cachexia (7, 10, and 14 days after tumour implantation). IFN-gamma protein expression was heterogeneously modulated in WAT, with increases in the mesenteric pad and decreased levels in the retroperitoneal depot along cachexia progression. Ifngr1 was up-regulated 7 days after tumour cell injection in mesenteric and epididymal WAT, but the retroperitoneal depot showed reduced Ifngr1 gene expression. Ifngr2 gene expression was increased 7 and 14 days after tumour inoculation in mesenteric WAT. The results provide evidence that changes in IFN-gamma expression and signalling may be perceived at stages preceding refractory cachexia, and therefore, might be employed as a means to assess the early stage of the syndrome.
Palavras-chave
Cancer-cachexia, White adipose tissue, Interferon-gamma signalling
URI
https://observatorio.fm.usp.br/handle/OPI/19897
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCG
Artigos e Materiais de Revistas Científicas - HU
Artigos e Materiais de Revistas Científicas - LIM/26
Artigos e Materiais de Revistas Científicas - ODS/03