https://observatorio.fm.usp.br/handle/OPI/19947
Title: | Does brain creatine content rely on exogenous creatine in healthy youth? A proof-of-principle study |
Authors: | MEREGE-FILHO, Carlos Alberto Abujabra; OTADUY, Maria Concepcion Garcia; SA-PINTO, Ana Lucia de; OLIVEIRA, Maira Okada de; GONCALVES, Livia de Souza; HAYASHI, Ana Paula Tanaka; ROSCHEL, Hamilton; PEREIRA, Rosa Maria Rodrigues; SILVA, Clovis Artur; BRUCKI, Sonia Maria Dozzi; LEITE, Claudia da Costa; GUALANO, Bruno |
Citation: | APPLIED PHYSIOLOGY NUTRITION AND METABOLISM, v.42, n.2, p.128-134, 2017 |
Abstract: | It has been hypothesized that dietary creatine could influence cognitive performance by increasing brain creatine in developing individuals. This double-blind, randomized, placebo-controlled, proof-of-principle study aimed to investigate the effects of creatine supplementation on cognitive function and brain creatine content in healthy youth. The sample comprised 67 healthy participants aged 10 to 12 years. The participants were given creatine or placebo supplementation for 7 days. At baseline and after the intervention, participants undertook a battery of cognitive tests. In a random subsample of participants, brain creatine content was also assessed in the regions of left dorsolateral prefrontal cortex, left hippocampus, and occipital lobe by proton magnetic resonance spectroscopy (1H-MRS) technique. The scores obtained from verbal learning and executive functions tests did not significantly differ between groups at baseline or after the intervention (all p > 0.05). Creatine content was not significantly different between groups in left dorsolateral prefrontal cortex, left hippocampus, and occipital lobe (all p > 0.05). In conclusion, a 7-day creatine supplementation protocol did not elicit improvements in brain creatine content or cognitive performance in healthy youth, suggesting that this population mainly relies on brain creatine synthesis rather than exogenous creatine intake to maintain brain creatine homeostasis. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - FM/MDR Artigos e Materiais de Revistas Científicas - FM/MPE Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/ICr Artigos e Materiais de Revistas Científicas - HC/InRad Artigos e Materiais de Revistas Científicas - LIM/17 Artigos e Materiais de Revistas Científicas - LIM/36 Artigos e Materiais de Revistas Científicas - LIM/44 Artigos e Materiais de Revistas Científicas - LIM/45 |
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art_MEREGE-FILHO_Does_brain_creatine_content_rely_on_exogenous_creatine_2017.PDF Restricted Access | publishedVersion (English) | 619.33 kB | Adobe PDF | View/Open Request a copy |
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