Allergic and Nonallergic Asthma Have Distinct Phenotypic and Genotypic Features
Carregando...
Citações na Scopus
17
Tipo de produção
article
Data de publicação
2017
Editora
KARGER
Indexadores
Título da Revista
ISSN da Revista
Título do Volume
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, v.172, n.3, p.150-160, 2017
Resumo
Background: Identification of asthma phenotypes enables a better understanding and management of this heterogeneous disease. Studies have reported associations between human leukocyte antigens (HLA) and asthma in different populations, but the results have been inconclusive and they have rarely considered the distinct disease phenotypes. Our objective was to characterize allergic and nonallergic asthma phenotypes and evaluate possible associations with the HLA system. Methods: A total of 109 patients with asthma were prospectively followed during 2 years. They were divided into 2 groups, i.e., allergic and nonallergic asthma, according to their clinical history and skin prick test and serum-specific immunoglobulin E (IgE) results. The control group comprised 297 deceased donors of solid organs. Patients' features and HLA class I and II genotypes were assessed and compared. Results: This study showed different features between asthma phenotypes. Nonallergic patients were older at the onset of asthma symptoms and had a higher rate of intolerance to nonsteroidal anti-inflammatory drugs. Allergic patients had higher total serum IgE levels, reported atopic dermatitis and rhinoconjunctivitis more frequently, and, unexpectedly, had a greater disease severity. New associations between the HLA genotypes and allergic and nonallergic asthma were identified. The HLA-B*42, HLA-C*17, HLA-DPA1*03, and HLA-DPB1*105 genotypes were associated with allergic asthma and the HLA-B*48 genotype with the nonallergic phenotype. The presence of the haplotype HLA-DPA1*03 DQA*05 was associated with allergic asthma, and the presence of HLA-DPA1*03 and the absence of HLA-DQA*05 with nonallergic asthma. Conclusions: Allergic and nonallergic asthma have distinct phenotypic and genotypic features. New associations between asthma phenotypes and HLA class I and II were identified. (C) 2017 S. Karger AG, Basel
Palavras-chave
Asthma, Human leukocyte antigens, Allergic asthma, Nonatopic
Referências
- Abraham B, 2003, EUR RESPIR J, V22, P470, DOI 10.1183/09031936.03.00261903
- Apostolakis J, 1996, RESP MED, V90, P201, DOI 10.1016/S0954-6111(96)90287-5
- Bousquet PJ, 2015, INT ARCH ALLERGY IMM, V166, P231, DOI 10.1159/000381339
- Bradding P, 2010, CURR OPIN ALLERGY CL, V10, P54, DOI 10.1097/ACI.0b013e32833489a9
- Breiman L., 1984, CLASSIFICATION REGRE
- BROSTOFF J, 1976, LANCET, V2, P872
- Brunner E, 2000, BIOMETRICAL J, V42, P17, DOI 10.1002/(SICI)1521-4036(200001)42:1<17::AID-BIMJ17>3.0.CO;2-U
- CARABALLO L, 1991, HUM IMMUNOL, V32, P157, DOI 10.1016/0198-8859(91)90051-A
- Charpin D, 2003, J ASTHMA, V40, P87, DOI 10.1081/JAS-120017211
- Comi AL, 2007, RESP MED, V101, P2526, DOI 10.1016/j.rmed.2007.07.010
- DiCiccio TJ, 1996, STAT SCI, V11, P189
- Dombrowicz D, 2002, IGE ANTI IGE THERAPY, P69
- Esmaeilzadeh H, 2015, AM J RHINOL ALLERGY, V29, pE63, DOI 10.2500/ajra.2015.29.4154
- Gao JM, 2003, CHINESE MED J-PEKING, V116, P1078
- Giavina-Bianchi P, 2015, J ALLERGY CLIN IMMUN, V135, P151, DOI 10.1016/j.jaci.2014.10.029
- Giavina-Bianchi P, 2013, J ALLERGY CLIN IMMUN, V131, P1261, DOI 10.1016/j.jaci.2013.01.050
- Haldar P, 2008, AM J RESP CRIT CARE, V178, P218, DOI [10.1164/rccm.200711-1754OC, 10.1164/rccm.200711-17540C]
- Hallstrand T, 2001, CLIN IMMUNOLOGY PRIN
- Heck S, 2015, INT ARCH ALLERGY IMM, V168, P241, DOI 10.1159/000443930
- HSIEH KH, 1991, TISSUE ANTIGENS, V38, P181, DOI 10.1111/j.1399-0039.1991.tb01893.x
- Ivkovic-Jurekovic I, 2011, COLLEGIUM ANTROPOL, V35, P1243
- Jenkins HA, 2003, CHEST, V124, P1318, DOI 10.1378/chest.124.4.1318
- Johansson SGO, 2001, ALLERGY, V56, P813, DOI 10.1034/j.1398-9995.2001.t01-1-00001.x
- Johansson SGO, 2004, J ALLERGY CLIN IMMUN, V113, P832, DOI 10.1016/j.jaci.2003.12.591
- Kontakioti E, 2014, HUM IMMUNOL, V75, P930, DOI 10.1016/j.humimm.2014.06.022
- Lara-Marquez ML, 1999, CLIN EXP ALLERGY, V29, P60
- LEOPOLD HC, 1965, J ALLERGY, V36, P175, DOI 10.1016/0021-8707(65)90165-6
- Leung DYM, 2004, J ALLERGY CLIN IMMUN, V113, P1
- Li XN, 2010, J ALLERGY CLIN IMMUN, V125, P328, DOI 10.1016/j.jaci.2009.11.018
- Lockey RF, 2014, J ALLER CL IMM-PRACT, V2, P682, DOI 10.1016/j.jaip.2014.09.008
- MACEK V, 1994, AM J RESP CRIT CARE, V150, P7
- MARSH DG, 1981, NEW ENGL J MED, V305, P1551, DOI 10.1056/NEJM198112243052603
- Martyn MB, 2010, ALLERGY ASTHMA PROC, V31, P120, DOI 10.2500/aap.2010.31.3321
- Menz G, 1998, ALLERGY, V53, P15
- Miranda C, 2004, J ALLERGY CLIN IMMUN, V113, P101, DOI 10.1016/j.jaci.2003.10.041
- Moffatt MF, 2010, NEW ENGL J MED, V363, P1211, DOI 10.1056/NEJMoa0906312
- MOLONEY JR, 1980, CLIN OTOLARYNGOL, V5, P183, DOI 10.1111/j.1365-2273.1980.tb01645.x
- Moore WC, 2007, J ALLERGY CLIN IMMUN, V119, P405, DOI 10.1016/j.jaci.2006.11.639
- Moore WC, 2010, AM J RESP CRIT CARE, V181, P315, DOI 10.1164/rccm.200906-0896OC
- Morris M J, 1977, Monogr Allergy, V11, P30
- MORRIS MJ, 1980, CLIN ALLERGY, V10, P173, DOI 10.1111/j.1365-2222.1980.tb02094.x
- Nahm DH, 2001, J KOREAN MED SCI, V16, P407
- Noguchi E, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002170
- OSTERGAARD PA, 1979, EUR J PEDIATR, V131, P263, DOI 10.1007/BF00444347
- Parapanissiou E, 2005, TISSUE ANTIGENS, V65, P481, DOI 10.1111/j.1399-0039.2005.00392.x
- Pillai P, 2011, ISRN ALLERGY, V2011
- RACKEMANN FM, 1947, AM J MED, V3, P601, DOI 10.1016/0002-9343(47)90204-0
- Romanet-Manent S, 2002, ALLERGY, V57, P607, DOI 10.1034/j.1398-9995.2002.23504.x
- SETTIPANE GA, 1977, J ALLERGY CLIN IMMUN, V59, P17, DOI 10.1016/0091-6749(77)90171-3
- SIBBALD B, 1979, THORAX, V34, P332, DOI 10.1136/thx.34.3.332
- Smit LAM, 2014, EUR RESPIR J, V44, P1234, DOI 10.1183/09031936.00068014
- Sociedade Brasileira de Pneumologia e Tisiologia, 2002, J PNEUMOL, V28, P1
- SZCZEKLIK A, 1995, AM J RESP CRIT CARE, V152, P1753
- THORSBY E, 1971, Tissue Antigens, V1, P147
- Toledo M F, 2016, Allergol Immunopathol (Madr), V44, P439, DOI 10.1016/j.aller.2016.02.006
- Torio A, 2000, EUR J IMMUNOGENET, V27, P81, DOI 10.1046/j.1365-2370.2000.00205.x
- TURTON CWG, 1979, THORAX, V34, P670, DOI 10.1136/thx.34.5.670
- ULRIK CS, 1992, J ASTHMA, V29, P29, DOI 10.3109/02770909209110638
- WANG WX, 1988, TISSUE ANTIGENS, V32, P215, DOI 10.1111/j.1399-0039.1988.tb01658.x
Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/19
Artigos e Materiais de Revistas Científicas - LIM/60
Artigos e Materiais de Revistas Científicas - ODS/03
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/19
Artigos e Materiais de Revistas Científicas - LIM/60
Artigos e Materiais de Revistas Científicas - ODS/03