Allergic and Nonallergic Asthma Have Distinct Phenotypic and Genotypic Features

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author TAKEJIMA, Priscila FMUSP-HC
AGONDI, Rosana Camara FMUSP-HC
RODRIGUES, Helcio FMUSP-HC
AUN, Marcelo Vivolo FMUSP-HC
KALIL, Jorge FMUSP-HC
GIAVINA-BIANCHI, Pedro FMUSP-HC
dc.date.issued 2017
dc.identifier.citation INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, v.172, n.3, p.150-160, 2017
dc.identifier.issn 1018-2438
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/19955
dc.description.abstract Background: Identification of asthma phenotypes enables a better understanding and management of this heterogeneous disease. Studies have reported associations between human leukocyte antigens (HLA) and asthma in different populations, but the results have been inconclusive and they have rarely considered the distinct disease phenotypes. Our objective was to characterize allergic and nonallergic asthma phenotypes and evaluate possible associations with the HLA system. Methods: A total of 109 patients with asthma were prospectively followed during 2 years. They were divided into 2 groups, i.e., allergic and nonallergic asthma, according to their clinical history and skin prick test and serum-specific immunoglobulin E (IgE) results. The control group comprised 297 deceased donors of solid organs. Patients' features and HLA class I and II genotypes were assessed and compared. Results: This study showed different features between asthma phenotypes. Nonallergic patients were older at the onset of asthma symptoms and had a higher rate of intolerance to nonsteroidal anti-inflammatory drugs. Allergic patients had higher total serum IgE levels, reported atopic dermatitis and rhinoconjunctivitis more frequently, and, unexpectedly, had a greater disease severity. New associations between the HLA genotypes and allergic and nonallergic asthma were identified. The HLA-B*42, HLA-C*17, HLA-DPA1*03, and HLA-DPB1*105 genotypes were associated with allergic asthma and the HLA-B*48 genotype with the nonallergic phenotype. The presence of the haplotype HLA-DPA1*03 DQA*05 was associated with allergic asthma, and the presence of HLA-DPA1*03 and the absence of HLA-DQA*05 with nonallergic asthma. Conclusions: Allergic and nonallergic asthma have distinct phenotypic and genotypic features. New associations between asthma phenotypes and HLA class I and II were identified. (C) 2017 S. Karger AG, Basel
dc.language.iso eng
dc.publisher KARGER
dc.relation.ispartof International Archives of Allergy and Immunology
dc.rights restrictedAccess
dc.subject Asthma; Human leukocyte antigens; Allergic asthma; Nonatopic
dc.subject.other bronchial-asthma; nonatopic asthma; cluster-analysis; hla antigens; revised nomenclature; intrinsic asthma; research-program; atopic asthma; nasal polyps; class-ii
dc.title Allergic and Nonallergic Asthma Have Distinct Phenotypic and Genotypic Features
dc.type article
dc.rights.holder Copyright KARGER
dc.description.group LIM/19
dc.description.group LIM/60
dc.identifier.doi 10.1159/000458151
dc.identifier.pmid 28380482
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author TAKEJIMA, Priscila:FM:
hcfmusp.author AGONDI, Rosana Camara:HC:LIM/19
hcfmusp.author RODRIGUES, Helcio:HC:INCOR
hcfmusp.author AUN, Marcelo Vivolo:FM:
hcfmusp.author KALIL, Jorge:FM:MCM
hcfmusp.author GIAVINA-BIANCHI, Pedro:FM:MCM
hcfmusp.origem.id 2-s2.0-85017135051
hcfmusp.origem.id WOS:000401163600003
hcfmusp.publisher.city BASEL
hcfmusp.publisher.country SWITZERLAND
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dc.description.index MEDLINE
dc.identifier.eissn 1423-0097
hcfmusp.citation.scopus 4
hcfmusp.citation.wos 4


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