Non-HDL cholesterol is a good predictor of the risk of increased arterial stiffness in postmenopausal women in an urban Brazilian population

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author ALVIM, Rafael de Oliveira
MOURAO-JUNIOR, Carlos Alberto
MAGALHAES, Gessica Lopes
OLIVEIRA, Camila Maciel de
KRIEGER, Jose Eduardo FMUSP-HC
MILL, Jose Geraldo
PEREIRA, Alexandre Costa FMUSP-HC
dc.date.issued 2017
dc.identifier.citation CLINICS, v.72, n.2, p.106-110, 2017
dc.identifier.issn 1807-5932
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/20000
dc.description.abstract OBJECTIVES: Increased arterial stiffness is an important determinant of the risk of cardiovascular disease. Lipid profile impairment, especially hypercholesterolemia, is associated with stiffer blood vessels. Thus, the aim of this study was to determine which of the five circulating lipid components (high-density lipoprotein cholesterol (HDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), low-density lipoprotein cholesterol (LDL), total cholesterol (TC) and triglycerides) is the best predictor of increased arterial stiffness in an urban Brazilian population. METHODS: A random sample of 1,662 individuals from the general population of Vitoria, Brazil (25-64 years), was selected, and lipid components were measured using standard methods. Pulse wave velocity was measured using a non-invasive automatic device, and increased arterial stiffness was defined as a pulse wave velocity >= 10 m/s. RESULTS: In men, only total cholesterol (OR = 1.59; CI = 1.02 to 2.48, p = 0.04) was associated with the risk of increased arterial stiffness. In women, HDL-C (OR= 1.99; CI=1.18 to 3.35, p=0.01) and non-HDL-C (OR= 1.61; CI=1.01 to 2.56, p=0.04) were good predictors of the risk of increased arterial stiffness. However, these associations were only found in postmenopausal women (OR= 2.06; CI=1.00 to 4.26, p=0.05 for HDL-C and OR= 1.83; CI= 1.01 to 3.33, p= 0.04 for non-HDL-C). CONCLUSION: Our findings indicate that both HDL-C and non-HDL-C are good predictors of the risk of increased arterial stiffness in postmenopausal women in an urban Brazilian population and may be useful tools for assessing the risk of arterial stiffness.
dc.language.iso eng
dc.publisher HOSPITAL CLINICAS, UNIV SAO PAULO
dc.relation.ispartof Clinics
dc.rights openAccess
dc.subject Non-HDL-C; Arterial Stiffness; Dyslipidemia; Menopause
dc.subject.other pulse-wave velocity; cardiovascular risk; metabolic syndrome; aortic stiffness; blood-pressure; hypertension; disease; lipids; apolipoproteins; distensibility
dc.title Non-HDL cholesterol is a good predictor of the risk of increased arterial stiffness in postmenopausal women in an urban Brazilian population
dc.type article
dc.rights.holder Copyright HOSPITAL CLINICAS, UNIV SAO PAULO
dc.description.group LIM/13
dc.identifier.doi 10.6061/clinics/2017(02)07
dc.identifier.pmid 28273234
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author KRIEGER, Jose Eduardo:FM:MCP
hcfmusp.author PEREIRA, Alexandre Costa:HC:INCOR
hcfmusp.author.external · ALVIM, Rafael de Oliveira:Univ Fed Espirito Santo, Dept Saude Publ, Vitoria, ES, Brazil
· MOURAO-JUNIOR, Carlos Alberto:Univ Fed Juiz de Fora, Dept Fisiol, Juiz De Fora, MG, Brazil
· MAGALHAES, Gessica Lopes:Univ Sao Paulo, Fac Med, Inst Coracao INCOR, Lab Genet & Cardiol Mol, Sao Paulo, SP, Brazil
· OLIVEIRA, Camila Maciel de:Univ Sao Paulo, Fac Med, Inst Coracao INCOR, Lab Genet & Cardiol Mol, Sao Paulo, SP, Brazil
· MILL, Jose Geraldo:Univ Fed Espirito Santo, Dept Saude Publ, Vitoria, ES, Brazil
hcfmusp.origem.id 2-s2.0-85014521745
hcfmusp.origem.id WOS:000395808800007
hcfmusp.origem.id SCIELO:S1807-59322017000200106
hcfmusp.publisher.city SAO PAULO
hcfmusp.publisher.country BRAZIL
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dc.description.index MEDLINE
dc.identifier.eissn 1980-5322
hcfmusp.citation.scopus 2
hcfmusp.citation.wos 1
hcfmusp.affiliation.country Brasil


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