Perinatal complications, lipid peroxidation, and mental health problems in a large community pediatric sample

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art_MANSUR_Perinatal_complications_lipid_peroxidation_and_mental_health_problems_2017.PDF (460.12 KB)
Citações na Scopus
9
Tipo de produção
article
Data de publicação
2017
Editora
SPRINGER
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
MANSUR, Rodrigo B.
CUNHA, Graccielle R.
ASEVEDO, Elson
ZUGMAN, Andre
RIOS, Adiel C.
SALUM, Giovanni A.
PAN, Pedro M.
GADELHA, Ary
LEVANDOWSKI, Mateus L.
BELANGERO, Sintia I.
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, v.26, n.5, p.521-529, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Replicated evidence indicates that perinatal complications are associated with increased markers of oxidative stress and with mental health problems in children. However, there are fewer reports on the impact of perinatal complications in later phases of development. We aimed to investigate the estimated effects of perinatal complications on levels of lipid peroxidation and on psychopathology in children and adolescents. The study is part of the High Risk Cohort Study for Psychiatric Disorders; the population was composed by 554 students, 6-14 years of age. Serum levels of malondialdehyde, a product of lipid peroxidation, were measured by the TBARS method. A household interview with parents and caregivers was conducted and included inquiries about perinatal history, the Child Behavior Checklist (CBCL), and parent's evaluation, using the Mini International Psychiatric Interview (MINI). We created a cumulative risk index, conceptualized as each individual's cumulative exposure to perinatal complications. Results indicate that perinatal complications were associated with higher levels of TBARS. After adjusting for age, gender, socio-economic status, CBCL total problems score, parental psychopathology, and childhood maltreatment, children exposed to 3 or more perinatal complications had an 26.9% (95% CI 9.9%, 46.6%) increase in TBARS levels, relative to the unexposed group. Exploratory mediation analysis indicated that TBARS levels partially mediated the association between perinatal complications and externalizing problems. In conclusion, an adverse intrauterine and/or early life environment, as proxied by the cumulative exposure to perinatal complications, was independently associated with higher levels of lipid peroxidation in children and adolescents.
Palavras-chave
Oxidative stress, Lipid peroxidation, Perinatal complications, Adverse early life environment, Childhood, Psychopathology
URI
https://observatorio.fm.usp.br/handle/OPI/20155
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - LIM/21
Artigos e Materiais de Revistas Científicas - ODS/03
Artigos e Materiais de Revistas Científicas - ODS/16