https://observatorio.fm.usp.br/handle/OPI/20165
Title: | Micro-Raman spectroscopic study of thyroid tissues |
Authors: | MEDEIROS NETO, Lazaro Pinto; CARVALHO, Luis Felipe das Chagas e Silva de; SANTOS, Laurita dos; SOTO, Claudio Alberto Tellez; CANEVARI, Renata de Azevedo; SANTOS, Andre Bandiera de Oliveira; MELLO, Evandro Sobroza; PEREIRA, Marina Aparecida; CERNEA, Claudio Roberto; BRANDAO, Lenine Garcia; MARTIN, Airton Abrahao |
Citation: | PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, v.17, p.164-172, 2017 |
Abstract: | Thyroid carcinomas are the most common endocrine malignancy. Inconclusive results for the analysis of malignancies are an issue in the diagnosis of thyroid carcinomas; 20% of thyroid cancer diagnoses are indeterminate or suspicious, resulting in a surgical procedure without immediate need. The use of Raman spectroscopy may help improve the diagnosis of thyroid carcinoma. In this study, 30 thyroid samples, including normal thyroid, goiter and thyroid cancer, were analyzed by confocal Raman spectroscopy. Principal component analysis (PCA), linear discriminant analysis (LDA) with cross validation and binary logistic regression (BLR) analysis were applied to discriminate among tissues. Significant discrimination was observed, with a consistent rate of concordant pairs of 89.2% for normal thyroid versus cancer, 85.7% for goiter versus cancer and 80.6% for normal thyroid versus goiter using just the amide III region. Raman spectroscopy was thus proven to be an important and fast tool for the diagnosis of thyroid tissues. The spectral region of 1200-1400 cm(-1) discriminated normal versus goiter tissues despite the great similarity of these tissues. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCG Artigos e Materiais de Revistas Científicas - FM/MPT Artigos e Materiais de Revistas Científicas - HC/ICESP Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/14 Artigos e Materiais de Revistas Científicas - LIM/28 Artigos e Materiais de Revistas Científicas - ODS/03 |
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art_MEDEIROS NETO_MicroRaman_spectroscopic_study_of_thyroid_tissues_2017.PDF Restricted Access | publishedVersion (English) | 1.44 MB | Adobe PDF | View/Open Request a copy |
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