Preconception allergen sensitization can induce B10 cells in offspring: a potential main role for maternal IgG

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author OLIVEIRA, Marlia Garcia de
OLIVEIRA, Luana de Mendonca FMUSP-HC
LIRA, Aline Aparecida de Lima FMUSP-HC
SGNOTTO, Fabio da Ressureicao
DUARTE, Alberto Jose da Silva FMUSP-HC
SATO, Maria Notomi FMUSP-HC
VICTOR, Jefferson Russo FMUSP-HC
dc.date.issued 2017
dc.identifier.citation ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY, v.13, article ID 22, 10p, 2017
dc.identifier.issn 1710-1484
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/20181
dc.description.abstract Background: The mechanisms through which allergies can be inhibited after preconception immunization with allergens are not fully understood. We aimed to evaluate whether maternal immunization can induce a regulatory B (B10) cell population in offspring in concert with allergy inhibition. Methods: C57BL/6 females were or were not immunized with OVA and were mated with normal WT males. Their offspring were evaluated at 3 days of age or 20 days after neonatal immunization. Human peripheral B cells from atopic and non-atopic individuals were also evaluated. Results: Preconception OVA immunization induced B10 cells in offspring, and IL-10 production appeared to be critical for FcyRIIB upregulation in offspring B cells. Murine and human IL-10-producing B cells responded in vitro to IgG according to the atopic repertoire of the cells. Conclusions: Our results reveal that maternal immunization induces allergen-specific B10 cells in offspring and a pivotal role for the IgG repertoire in IL-10 production by murine and human B cells.
dc.description.sponsorship · Sao Paulo Research Foundation (FAPESP) [2015/17256-3, 2013/22820-0, 2010/09004-0]
· National Council for Scientific and Technological Development (CNPq) [115603/2015-8]
· Laboratory of Medical Investigation-56, Medical School, University of Sao Paulo, Sao Paulo, Brazil (LIM-56 HC-FMUSP)
dc.language.iso eng
dc.publisher BIOMED CENTRAL LTD
dc.relation.ispartof Allergy Asthma and Clinical Immunology
dc.rights openAccess
dc.subject Allergy; Allergen-specific IgG; B10 cells; IL-10; Maternal immunization
dc.subject.other i hypersensitivity response; gamma-riib expression; regulatory b-cells; dermatophagoides-pteronyssinus; immunization; ovalbumin; immunotherapy; antibodies; tolerance; exposure
dc.title Preconception allergen sensitization can induce B10 cells in offspring: a potential main role for maternal IgG
dc.type article
dc.rights.holder Copyright BIOMED CENTRAL LTD
dc.description.group LIM/56
dc.identifier.doi 10.1186/s13223-017-0195-8
dc.identifier.pmid 28428801
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author OLIVEIRA, Luana de Mendonca:HC:LIM/56
hcfmusp.author LIRA, Aline Aparecida de Lima:HC:LIM/56
hcfmusp.author DUARTE, Alberto Jose da Silva:FM:MPT
hcfmusp.author SATO, Maria Notomi:FM:MDT
hcfmusp.author VICTOR, Jefferson Russo:FM:
hcfmusp.author.external · OLIVEIRA, Marlia Garcia de:Univ Sao Paulo, Med Sch, Div Clin Dermatol, Lab Med Invest LIM 56, Av Dr Eneas Carvalho Aguiar 500,3rd Floor, BR-05403000 Sao Paulo, Brazil
· SGNOTTO, Fabio da Ressureicao:Univ Sao Paulo, Med Sch, Div Clin Dermatol, Lab Med Invest LIM 56, Av Dr Eneas Carvalho Aguiar 500,3rd Floor, BR-05403000 Sao Paulo, Brazil
hcfmusp.origem.id WOS:000401022100001
hcfmusp.origem.id 2-s2.0-85018503331
hcfmusp.publisher.city LONDON
hcfmusp.publisher.country ENGLAND
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dc.description.index PubMed
dc.identifier.eissn 1710-1492
hcfmusp.citation.scopus 5
hcfmusp.citation.wos 5
hcfmusp.affiliation.country Brasil


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