Age- and Sex-Dependent Changes of Intra-articular Cortical and Trabecular Bone Structure and the Effects of Rheumatoid Arthritis

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art_SIMON_Age_and_SexDependent_Changes_of_Intraarticular_Cortical_and_2017.PDF (1.38 MB)
Citações na Scopus
32
Tipo de produção
article
Data de publicação
2017
Editora
WILEY
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
SIMON, David
KLEYER, Arnd
STEMMLER, Fabian
SIMON, Christoph
BERLIN, Andreas
HUEBER, Axel J.
HASCHKA, Judith
RENNER, Nina
NEUHUBER, Winfried
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
JOURNAL OF BONE AND MINERAL RESEARCH, v.32, n.4, p.722-730, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The objective of this cross-sectional study was to define normal sex- and age-dependent values of intra-articular bone mass and microstructures in the metacarpal heads of healthy individuals by high-resolution peripheral quantitative computed tomography (HR-pQCT) and test the effect of rheumatoid arthritis (RA) on these parameters. Human cadaveric metacarpal heads were used to exactly define intra-articular bone. Healthy individuals of different sex and age categories and RA patients with similar age and sex distribution received HR-pQCT scans of the second metacarpal head and the radius. Total, cortical, and trabecular bone densities as well as microstructural parameters were compared between 1) the different ages and sexes in healthy individuals; 2) between metacarpal heads and the radius; and 3) between healthy individuals and RA patients. The cadaveric study allowed exact definition of the intra-articular (intracapsular) bone margins. These data were applied in measuring intra-articular and radial bone parameters in 214 women and men (108 healthy individuals, 106 RA patients). Correlations between intra-articular and radial bone parameters were good (r=0.51 to 0.62, p<0.001). In contrast to radial bone, intra-articular bone remained stable until age 60 years (between 297 and 312mg HA/cm(3)) but decreased significantly (p<0.001) in women thereafter (237.5 +/- 44.3) with loss of both cortical and trabecular bone. Similarly, RA patients showed significant (p<0.001) loss of intra-articular total (263.0 +/- 44.8), trabecular (171.2 +/- 35.6), and cortical bone (610.2 +/- 62.0) compared with sex- and age-adjusted controls. Standard sex- and age-dependent values for physiological intra-articular bone were defined. Postmenopausal state and RA led to significant decrease of intra-articular bone. (c) 2016 American Society for Bone and Mineral Research.
Palavras-chave
INTRA-ARTICULAR BONE STRUCTURE, RHEUMATOID ARTHRITIS, HR-pQCT
URI
https://observatorio.fm.usp.br/handle/OPI/20201
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Coleções
Artigos e Materiais de Revistas Científicas - FM/Outros