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https://observatorio.fm.usp.br/handle/OPI/20300
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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | EIBEL, Bruna | - |
dc.contributor.author | MARKOSKI, Melissa M. | - |
dc.contributor.author | RODRIGUES, Clarissa G. | - |
dc.contributor.author | DIPP, Thiago | - |
dc.contributor.author | SALLES, Felipe B. de | - |
dc.contributor.author | GIUSTI, Imarilde I. | - |
dc.contributor.author | NARDI, Nance B. | - |
dc.contributor.author | PLENTZ, Rodrigo D. M. | - |
dc.contributor.author | KALIL, Renato A. K. | - |
dc.date.accessioned | 2017-06-09T15:39:34Z | - |
dc.date.available | 2017-06-09T15:39:34Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | CYTOKINE, v.91, p.44-50, 2017 | - |
dc.identifier.issn | 1043-4666 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/20300 | - |
dc.description.abstract | Background: New vessels are formed in response to stimuli from angiogenic factors, a process in which paracrine signaling is fundamental. Objective: To investigate the cooperative paracrine signaling profile in response to Vascular Endothelial Growth Factor (VEGF) gene therapy in patients with coronary artery disease (CAD) and refractory angina. Method: A cohort study was conducted in which plasma was collected from patients who underwent gene therapy with a plasmid expressing VEGF 165 (10) and from surgical procedure controls (4). Blood samples were collected from both groups prior to baseline and on days 3, 9 and 27 after the interventions and subjected to systemic analysis of protein expression (Interleukin-6, IL-6; Tumor Necrosis Factor-alpha ,TNF-alpha; Interleukin-10, IL-10; Stromal Derived Factor-1 alpha, SDF-1 alpha; VEGF; Angiopoietin-1, ANGPT-1; and Endothelin-1, ET-1) using the enzyme-linked immunosorbent assay (ELISA). Results: Analysis showed an increase in proinflammatory IL-6 (p = 0.02) and ET-1 (p = 0.05) on day 3 after gene therapy and in VEGF (p = 0.02) on day 9. A strong positive correlation was found between mobilization of endothelial progenitor cells and TNF-a on day 9 (r = 0.71; p = 0.03). Furthermore, a strong correlation between beta-blockers, antiplatelets, and vasodilators with SDF-l alpha baseline in the group undergoing gene therapy was verified (r = 0.74; p = 0.004). Conclusion: Analysis of cooperative paracrine signaling after VEGF gene therapy suggests that the immune system cell and angiogenic molecule expression as well as the endothelial progenitor cell mobilization are time-dependent, influenced by chronic inflammatory process and continuous pharmacological treatment. | - |
dc.description.sponsorship | Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS), | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) | - |
dc.description.sponsorship | Fundo de Apoio do Institute de Cardiologia/Fundacdo Universitaria de Cardiologia a Ciencia e Cultura (FAPICC) | - |
dc.language.iso | eng | - |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | - |
dc.relation.ispartof | Cytokine | - |
dc.rights | restrictedAccess | - |
dc.subject | Coronary artery disease | - |
dc.subject | Refractory angina | - |
dc.subject | Vascular endothelial growth factor | - |
dc.subject | Gene therapy | - |
dc.subject | Cell homing | - |
dc.subject | Angiogenesis | - |
dc.subject.other | endothelial growth-factor | - |
dc.subject.other | coronary-artery-disease | - |
dc.subject.other | stem-cells | - |
dc.subject.other | trial | - |
dc.subject.other | angiopoietin-1 | - |
dc.subject.other | migration | - |
dc.subject.other | neovascularization | - |
dc.subject.other | vasoconstriction | - |
dc.subject.other | cardiomyopathy | - |
dc.subject.other | proliferation | - |
dc.title | VEGF gene therapy cooperatively recruits molecules from the immune system and stimulates cell homing and angiogenesis in refractory angina | - |
dc.type | article | - |
dc.rights.holder | Copyright ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | - |
dc.identifier.doi | 10.1016/j.cyto.2016.12.005 | - |
dc.identifier.pmid | 27997860 | - |
dc.subject.wos | Biochemistry & Molecular Biology | - |
dc.subject.wos | Cell Biology | - |
dc.subject.wos | Immunology | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | EIBEL, Bruna:Fundaccio Univ Cardiol, Inst Cardiol, Secretaria Cirurg, Lab Cardiol Mol & Celular,Serv Med Expt, Porto Alegre, RS, Brazil | - |
hcfmusp.author.external | MARKOSKI, Melissa M.:Fundaccio Univ Cardiol, Inst Cardiol, Secretaria Cirurg, Lab Cardiol Mol & Celular,Serv Med Expt, Porto Alegre, RS, Brazil | - |
hcfmusp.author.external | RODRIGUES, Clarissa G.:Fundaccio Univ Cardiol, Inst Cardiol, Secretaria Cirurg, Lab Cardiol Mol & Celular,Serv Med Expt, Porto Alegre, RS, Brazil | - |
hcfmusp.author.external | DIPP, Thiago:Fac Desenvolvimento Rio Grande do Sul FADERGS, Porto Alegre, RS, Brazil | - |
hcfmusp.author.external | GIUSTI, Imarilde I.:Fundaccio Univ Cardiol, Inst Cardiol, Secretaria Cirurg, Lab Cardiol Mol & Celular,Serv Med Expt, Porto Alegre, RS, Brazil | - |
hcfmusp.author.external | NARDI, Nance B.:Univ Luterana Brasil ULBRA, Canoas, RS, Brazil | - |
hcfmusp.author.external | PLENTZ, Rodrigo D. M.:Univ Fed Ciencias Saude Porto Alegre, Porto Alegre, RS, Brazil | - |
hcfmusp.author.external | KALIL, Renato A. K.:Fundaccio Univ Cardiol, Inst Cardiol, Secretaria Cirurg, Lab Cardiol Mol & Celular,Serv Med Expt, Porto Alegre, RS, Brazil; Univ Fed Ciencias Saude Porto Alegre, Porto Alegre, RS, Brazil | - |
hcfmusp.description.beginpage | 44 | - |
hcfmusp.description.endpage | 50 | - |
hcfmusp.description.volume | 91 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000395840600007 | - |
hcfmusp.origem.id | 2-s2.0-85006341312 | - |
hcfmusp.publisher.city | LONDON | - |
hcfmusp.publisher.country | ENGLAND | - |
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dc.description.index | MEDLINE | - |
dc.identifier.eissn | 1096-0023 | - |
hcfmusp.citation.scopus | 4 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - ODS/03 |
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