The effect of fetal anemia on fetal cardiac troponin T in pregnancies complicated by RhD alloimmunization

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author NOMURA, Roseli Mieko Yamamoto FMUSP-HC
BRIZOT, Maria de Lourdes FMUSP-HC
LIAO, Adolfo Wenjaw FMUSP-HC
NISHIE, Estela Naomi FMUSP-HC
ZUGAIB, Marcelo FMUSP-HC
dc.date.issued 2013
dc.identifier.citation JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, v.26, n.3, p.246-249, 2013
dc.identifier.issn 1476-7058
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/2054
dc.description.abstract Objective: To study the effect of fetal anemia on fetal cardiac troponin T (cTnT) in pregnancies complicated by RhD alloimmunization. Method: Twenty pregnant women complicated by RhD alloimmunization who underwent intrauterine transfusion (IUT) for treatment of fetal anemia were studied. Immediately before IUT, fetal blood was obtained for hemoglobin and cTnT measurements. Results: Complete measurements of hemoglobin and cTnT before IUT were obtained in 49 procedures, of which 20 were first-time. The regression analysis between hemoglobin z-score and cTnT values in 49 procedures showed significant negative correlation (r = -0.43, p = 0.002, Regression equation Log(cTnT) = -1.5057 + -0.07563 Hb z-score). Cardiac TnT values before first IUT were significantly associated with perinatal death. In the group with elevated cTnT (n = 7), fetal or neonatal death was more frequent (2 IUD and 2 NND) when compared to normal cTnT group (n = 13, 1 IUD) (57.1 vs. 7.7%, p = 0.031, Fisher's exact test). Conclusion: Fetal blood concentration of cTnT before IUT was negatively correlated to hemoglobin z-score, and levels of cTnT help to manage the pregnancies complicated by RhD alloimmunization.
dc.language.iso eng
dc.publisher INFORMA HEALTHCARE
dc.relation.ispartof Journal of Maternal-Fetal & Neonatal Medicine
dc.rights restrictedAccess
dc.subject Alloimmunization; fetal anemia; troponin T
dc.subject.other red-cell isoimmunization; intrauterine transfusion; placental insufficiency; hydrops-fetalis; hemoglobin; fetuses; blood; rat; hematocrit; apoptosis
dc.title The effect of fetal anemia on fetal cardiac troponin T in pregnancies complicated by RhD alloimmunization
dc.type article
dc.rights.holder Copyright INFORMA HEALTHCARE
dc.description.group LIM/57
dc.identifier.doi 10.3109/14767058.2012.733746
dc.identifier.pmid 23013237
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author NOMURA, Roseli Mieko Yamamoto:FM:MOG
hcfmusp.author BRIZOT, Maria de Lourdes:FM:MOG
hcfmusp.author LIAO, Adolfo Wenjaw:FM:MOG
hcfmusp.author NISHIE, Estela Naomi:FM:
hcfmusp.author ZUGAIB, Marcelo:FM:MOG
hcfmusp.origem.id 2-s2.0-84872284547
hcfmusp.origem.id WOS:000313681200007
hcfmusp.publisher.city LONDON
hcfmusp.publisher.country ENGLAND
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dc.description.index MEDLINE
hcfmusp.citation.scopus 3
hcfmusp.citation.wos 3


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