Therapy of Canine Hyperlipidemia with Bezafibrate

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Arquivos
art_MARCO_Therapy_of_Canine_Hyperlipidemia_with_Bezafibrate_2017.PDF (405.58 KB)
Citações na Scopus
25
Tipo de produção
article
Data de publicação
2017
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY
Autores
MARCO, V. De
NORONHA, K. S. M.
CASADO, T. C.
FLORIO, J. C.
SANTOS, E. Z.
GILOR, C.
Citação
JOURNAL OF VETERINARY INTERNAL MEDICINE, v.31, n.3, p.717-722, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: Bezafibrate (BZF) is effective in the treatment of hypertriglyceridemia in human patients, but there are no data on its use in dogs. Objective: To assess the safety of BZF in hyperlipidemic dogs and its efficacy in decreasing serum triglyceride (TG) and cholesterol (CHO) concentrations. Animals: Forty-six dogs, 26 females and 20 males, mean (+/-SD) age of 9 (+/-3) years, with TG = 150 mg/dL (33 dogs also were hypercholesterolemic [>300 mg/dL]). Methods: Prospective, uncontrolled clinical trial. Dogs were treated with bezafibrate once daily, using 200 mg tablets at a dosage of 4-10 mg/kg (depending on body weight). Serum TG and CHO concentrations and alanine aminotransferase (ALT) and creatine kinase (CK) activity before and after 30 days of treatment were compared. Results: Sixteen dogs (34.8%) had primary hyperlipidemia, and 30 dogs (65.2%) had secondary hyperlipidemia (including spontaneous hyperadrenocorticism [41.3%, n = 19/46], chronic treatment with glucocorticoids [10.8%, n = 5/46], and hypothyroidism [15.2%, n = 7/46]). After 30 days, serum TG concentration normalized (< 150 mg/dL) in 42 dogs (91.3%) and CHO concentration normalized (< 270 mg/dL) in 22 of 33 dogs (66.7%). There was no difference in baseline TG concentration between the primary and secondary hyperlipidemia subgroups, but the decrease in TG concentration after treatment was greater in the primary hyperlipidemia subgroup. No adverse effects were observed, but ALT activity decreased significantly after 30 days of treatment. Conclusions and Clinical Importance: Over 30 days, BZF was safe and effective in treatment of primary and secondary hyperlipidemia in dogs.
Palavras-chave
Cholesterol, Hyperadrenocorticism, Peroxisome proliferator-activated receptor, Schnauzer, Triglyceride
URI
https://observatorio.fm.usp.br/handle/OPI/21227
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - LIM/10