Effects of Ethnicity on the Prevalence of Obstructive Sleep Apnoea in Patients with Acute Coronary Syndrome: A Pooled Analysis of the ISAACC Trial and Sleep and Stent Study

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author KOO, Chieh-Yang
TORRE, Alicia Sanchez de la
LOO, Germaine
TORRE, Manuel Sanchez-de-la
ZHANG, Junjie
DURAN-CANTOLLA, Joaquin
LI, Ruogu
MAYOS, Merce
SETHI, Rishi
ABAD, Jorge
FURLAN, Sofia F. FMUSP-HC
COLOMA, Ramon
HEIN, Thet
HO, Hee-Hwa
JIM, Man-Hong
ONG, Thun-How
TAI, Bee-Choo
TURINO, Cecilia
DRAGER, Luciano F. FMUSP-HC
LEE, Chi-Hang
BARBE, Ferran
dc.date.issued 2017
dc.identifier.citation HEART LUNG AND CIRCULATION, v.26, n.5, p.486-494, 2017
dc.identifier.issn 1443-9506
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/21231
dc.description.abstract Background Obstructive sleep apnoea (OSA) is an emerging risk factor for acute coronary syndrome (ACS). We sought to determine the effects of ethnicity on the prevalence of OSA in patients presenting with ACS who participated in an overnight sleep study. Methods A pooled analysis using patient-level data from the ISAACC Trial and Sleep and Stent Study was performed. Using the same portable diagnostic device, OSA was defined as an apnoea-hypopnoea index of >= 15 events per hour. Results A total of 1961 patients were analysed, including Spanish (53.6%, n=1050), Chinese (25.5%, n=500), Indian (12.0%, n=235), Malay (6.1%, n=119), Brazilian (1.7%, n=34) and Burmese (1.2%, n=23) populations. Significant differences in body mass index (BMI) were found among the various ethnic groups, averaging from 25.3 kg/m(2) for Indians and 25.4 kg/m(2) for Chinese to 28.6 kg/m(2) for Spaniards. The prevalence of OSA was highest in the Spanish (63.1%), followed by the Chinese (50.2%), Malay (47.9%), Burmese (43.5%), Brazilian (41.2%), and Indian (36.1%) patients. The estimated odds ratio of BMI on OSA was highest in the Chinese population (1.17; 95% confidence interval: 1.10-1.24), but was not significant in the Spanish, Burmese or Brazilian populations. The area under the curve (AUC) for the Asian patients (ranging from 0.6365 to 0.6692) was higher than that for the Spanish patients (0.5161). Conclusion There was significant ethnic variation in the prevalence of OSA in patients with ACS. The magnitude of the effect of BMI on OSA was greater in the Chinese population than in the Spanish patients.
dc.description.sponsorship · Fondo de Investigacion Sanitaria [PI10/02763, PI10/02745]
· Spanish Respiratory Society (SEPAR)
· Catalonian Cardiology Society
· ResMed Ltd. (Australia)
· Esteve-Teijin (Spain)
· Oxigen Salud (Spain)
· ALLER
· Investigator Initiated Program of the Boston Scientific Corporation
· Clinician Scientist Program of the National University Health System of Singapore
· FAPESP [2012/02953-2]
dc.language.iso eng
dc.publisher ELSEVIER SCIENCE INC
dc.relation.ispartof Heart Lung and Circulation
dc.rights restrictedAccess
dc.subject Obstructive sleep apnoea; Acute coronary syndrome
dc.subject.other acute myocardial-infarction; american-heart-association; outcomes; disease; impact; atherosclerosis; intervention; progression; cardiology; rationale
dc.title Effects of Ethnicity on the Prevalence of Obstructive Sleep Apnoea in Patients with Acute Coronary Syndrome: A Pooled Analysis of the ISAACC Trial and Sleep and Stent Study
dc.type article
dc.rights.holder Copyright ELSEVIER SCIENCE INC
dc.description.group LIM/09
dc.identifier.doi 10.1016/j.hlc.2016.09.010
dc.identifier.pmid 27939743
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author FURLAN, Sofia F.:HC:INCOR
hcfmusp.author DRAGER, Luciano F.:FM:MCM
hcfmusp.author.external · KOO, Chieh-Yang:Natl Univ Heart Ctr, Dept Cardiol, 5 Lower Kent Ridge Rd, Singapore 119074, Singapore; Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore
· TORRE, Alicia Sanchez de la:Hosp Univ Arnau de Vilanova & Santa Maria, IRB Lleida, Resp Dept, Lleida, Spain; CIBERES, Madrid, Spain
· LOO, Germaine:Natl Univ Heart Ctr, Dept Cardiol, 5 Lower Kent Ridge Rd, Singapore 119074, Singapore; Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore
· TORRE, Manuel Sanchez-de-la:Hosp Univ Arnau de Vilanova & Santa Maria, IRB Lleida, Resp Dept, Lleida, Spain; CIBERES, Madrid, Spain
· ZHANG, Junjie:Nanjing First Hosp, Dept Cardiol, Nanjing, Jiangsu, Peoples R China
· DURAN-CANTOLLA, Joaquin:CIBERES, Madrid, Spain; Univ Basque Country, Dept Med, Araba Univ Hosp, Bioaraba Res Inst, Vitoria, Spain
· LI, Ruogu:Shanghai Chest Hosp, Dept Cardiol, Shanghai, Peoples R China
· MAYOS, Merce:CIBERES, Madrid, Spain; Hosp Santa Creu & Sant Pau, Dept Resp Med, Sleep Unit, Barcelona, Spain
· SETHI, Rishi:King Georges Med Univ, Dept Cardiol, Lucknow, Uttar Pradesh, India
· ABAD, Jorge:Hosp Badalona Germans Trias & Pujol, Resp Dept, Barcelona, Catalonia, Spain
· COLOMA, Ramon:Hosp Gen Univ Albacete, Resp Dept, Albacete, Spain
· HEIN, Thet:1 1000 Bedded Def Serv Gen Hosp, Mingaladon, Yangon, Myanmar
· HO, Hee-Hwa:Tan Tock Seng Hosp, Dept Cardiol, Singapore, Singapore
· JIM, Man-Hong:Grantham Hosp, Cardiac Med Unit, Hong Kong, Hong Kong, Peoples R China
· ONG, Thun-How:Singapore Gen Hosp, Dept Resp & Crit Care Med, Singapore, Singapore
· TAI, Bee-Choo:Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore
· TURINO, Cecilia:Hosp Univ Arnau de Vilanova & Santa Maria, IRB Lleida, Resp Dept, Lleida, Spain
· LEE, Chi-Hang:Natl Univ Heart Ctr, Dept Cardiol, 5 Lower Kent Ridge Rd, Singapore 119074, Singapore; Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore
· BARBE, Ferran:Hosp Univ Arnau de Vilanova & Santa Maria, IRB Lleida, Resp Dept, Lleida, Spain; CIBERES, Madrid, Spain
hcfmusp.origem.id WOS:000402465300009
hcfmusp.origem.id 2-s2.0-85008186391
hcfmusp.publisher.city NEW YORK
hcfmusp.publisher.country USA
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dc.description.index MEDLINE
dc.identifier.eissn 1444-2892
hcfmusp.citation.scopus 4
hcfmusp.citation.wos 3
hcfmusp.affiliation.country Brasil
hcfmusp.affiliation.country China
hcfmusp.affiliation.country Singapura
hcfmusp.affiliation.country Myanmar
hcfmusp.affiliation.country Espanha
hcfmusp.affiliation.country Índia


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