Serum RBP4 and CKD: Association with insulin resistance and lipids

Imagem de Miniatura
Arquivos
art_DOMINGOS_Serum_RBP4_and_CKD_Association_with_insulin_resistance_2017.PDF (331.51 KB)
Citações na Scopus
9
Tipo de produção
article
Data de publicação
2017
Editora
ELSEVIER SCIENCE INC
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
JOURNAL OF DIABETES AND ITS COMPLICATIONS, v.31, n.7, p.1132-1138, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective: Serum RBP4 is new adipokine and it has been related to insulin resistance and diabetes risk in animal and clinical studies. However, there is controversy on this relationship among CKD patients. In this study, we evaluated the association of serum RBP4 with insulin resistance and cardiovascular risk factors in CKD. Methods: Baseline data from the PROGREDIR Study (Sao Paulo, Brazil) comprising 454 participants (mainly stages 3 and 4) was analyzed. Results: In univariable analysis, RBP4 was inversely related to renal function, age and HDL, and positively related to other lipids, insulinemia, HOMA, glycemia, albumin, phosphorus and right hepatic lobe diameter. After adjustment for sex, age and eGFR, HOMA and lipids remained associated to RBP4. In multivariable analysis, eGFR and triglyceride remained significantly associated with RBP4, while HOMA showed no longer a significant positive association. An interaction term between RBP4 and eGFR was significantly related to HOMA. Conclusions: Renal function is inversely related to serum RBP4. As GFR decreases, the relationship between RBP4 and HOMA is attenuated. On the other hand, triglycerides remained strongly related to RBP4 and this was not affected by eGFR, suggesting that in the CKD population triglycerides may be a better marker of RBP4-associated metabolic effects.
Palavras-chave
CKD, Serum RBP4, Adipokine, Insulin resistance, Triglycerides
URI
https://observatorio.fm.usp.br/handle/OPI/21259
Referências
  1. BERNARD A, 1988, CLIN CHIM ACTA, V171, P85, DOI 10.1016/0009-8981(88)90293-8
  2. BURRI BJ, 1990, CLIN CHEM, V36, P674
  3. Chavez AO, 2009, AM J PHYSIOL-ENDOC M, V296, pE758, DOI 10.1152/ajpendo.90737.2008
  4. Cho YM, 2006, DIABETES CARE, V29, P2457, DOI 10.2337/dc06-0360
  5. D'Ambrosio DN, 2011, NUTRIENTS, V3, P63, DOI 10.3390/nu3010063
  6. de Boer IH, 2016, J AM SOC NEPHROL, V27, P2861, DOI 10.1681/ASN.2015070756
  7. Domingos MAM, 2017, SAO PAULO M IN PRESS
  8. Fliser D, 1998, KIDNEY INT, V53, P1343, DOI 10.1046/j.1523-1755.1998.00898.x
  9. Flower DR, 1996, BIOCHEM J, V318, P1
  10. Frey SK, 2008, LIPIDS HEALTH DIS, V7, DOI 10.1186/1476-511X-7-29
  11. Goulart AC, 2015, SAO PAULO MED J, V133, P115, DOI 10.1590/1516-3180.2014.9150812
  12. Graham TE, 2007, DIABETOLOGIA, V50, P814, DOI 10.1007/s00125-006-0557-0
  13. Graham TE, 2006, NEW ENGL J MED, V354, P2552, DOI 10.1056/NEJMoa054862
  14. HAGER SR, 1989, AM J KIDNEY DIS, V14, P272
  15. Haider DG, 2007, J CLIN ENDOCR METAB, V92, P1168, DOI 10.1210/jc.2006-1839
  16. Henze A, 2010, BIOCHEM BIOPH RES CO, V393, P79, DOI 10.1016/j.bbrc.2010.01.082
  17. Henze A, 2008, DIABETES, V57, P3323, DOI 10.2337/db08-0866
  18. Hermsdorff HHM, 2011, INFLAMMATION, V34, P161, DOI 10.1007/s10753-010-9219-y
  19. Jaconi S, 1996, EUR J ENDOCRINOL, V134, P576
  20. KANAI M, 1968, J CLIN INVEST, V47, P2025, DOI 10.1172/JCI105889
  21. Kloeting N, 2007, CELL METAB, V6, P79, DOI 10.1016/j.cmet.2007.06.002
  22. Koppe L, 2014, NEPHROL DIAL TRANSPL, V29, P1666, DOI 10.1093/ndt/gft435
  23. Levey AS, 2009, ANN INTERN MED, V150, P604
  24. Liu Y, 2016, J CLIN ENDOCR METAB, V101, P4338, DOI 10.1210/jc.2016-1320
  25. MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
  26. McGarry JD, 2002, DIABETES, V51, P7
  27. Mody N, 2008, AM J PHYSIOL-ENDOC M, V294, pE785, DOI 10.1152/ajpendo.00521.2007
  28. Musso G, 2016, DIABETES CARE, V39, P1830, DOI 10.2337/dc15-1182
  29. PEREIRA AB, 1993, CLIN CHEM, V39, P472
  30. Promintzer M, 2007, J CLIN ENDOCR METAB, V92, P4306, DOI 10.1210/jc.2006-2522
  31. Seo JA, 2008, CLIN ENDOCRINOL, V68, P555, DOI 10.1111/j.1365-2265.2007.03072.x
  32. Spoto B, 2016, AM J PHYSIOL-RENAL, V311, pF1087, DOI 10.1152/ajprenal.00340.2016
  33. Trirogoff ML, 2007, AM J CLIN NUTR, V86, P1642
  34. Uelgen Fatma, 2010, Archives of Physiology and Biochemistry, V116, P57, DOI 10.3109/13813451003631421
  35. Vitkova M, 2007, J CLIN ENDOCR METAB, V92, P2330, DOI 10.1210/jc.2006-2668
  36. von Eynatten M, 2007, DIABETOLOGIA, V50, P1930, DOI 10.1007/s00125-007-0743-8
  37. Xu H, 2014, CLIN J AM SOC NEPHRO, V9, P690, DOI 10.2215/CJN.05230513
  38. Yang Q, 2005, NATURE, V436, P356, DOI 10.1038/nature03711
  39. Zanetti M, 2008, J RENAL NUTR, V18, P70, DOI 10.1053/j.jrn.2007.10.015

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/20
Artigos e Materiais de Revistas Científicas - ODS/03