Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG)

Imagem de Miniatura
Arquivos
art_KOVACS_Multisite_Assessment_of_AgingRelated_Tau_Astrogliopathy_ARTAG_2017.PDF (2.14 MB)
Citações na Scopus
34
Tipo de produção
article
Data de publicação
2017
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
OXFORD UNIV PRESS INC
Autores
KOVACS, Gabor G.
XIE, Sharon X.
LEE, Edward B.
ROBINSON, John L.
CASWELL, Carrie
IRWIN, David J.
TOLEDO, Jon B.
JOHNSON, Victoria E.
SMITH, Douglas H.
ALAFUZOFF, Irina
Citação
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, v.76, n.7, p.605-619, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Aging-related tau astrogliopathy (ARTAG) is a recently introduced terminology. To facilitate the consistent identification of ARTAG and to distinguish it from astroglial tau pathologies observed in the primary frontotemporal lobar degeneration tauopathies we evaluated how consistently neuropathologists recognize (1) different astroglial tau immunoreactivities, including those of ARTAG and those associated with primary tauopathies (Study 1); (2) ARTAG types (Study 2A); and (3) ARTAG severity (Study 2B). Microphotographs and scanned sections immunostained for phosphorylated tau (AT8) were made available for download and preview. Percentage of agreement and kappa values with 95% confidence interval (CI) were calculated for each evaluation. The overall agreement for Study 1 was > 60% with a kappa value of 0.55 (95% CI 0.433-0.645). Moderate agreement (> 90%, kappa 0.48, 95% CI 0.457-0.900) was reached in Study 2A for the identification of ARTAG pathology for each ARTAG subtype (kappa 0.37-0.72), whereas fair agreement (kappa 0.40, 95% CI 0.341-0.445) was reached for the evaluation of ARTAG severity. The overall assessment of ARTAG showed moderate agreement (kappa 0.60, 95% CI 0.534-0.653) among raters. Our study supports the application of the current harmonized evaluation strategy for ARTAG with a slight modification of the evaluation of its severity.
Palavras-chave
Aging, ARTAG, Digital pathology, Interrater agreement, Neuropathology, Tau, Tau-astrogliopathy
URI
https://observatorio.fm.usp.br/handle/OPI/21428
Referências
  1. Ahmed Z, 2013, ACTA NEUROPATHOL, V126, P537, DOI 10.1007/s00401-013-1171-0
  2. Alafuzoff I, 2008, BRAIN PATHOL, V18, P484, DOI 10.1111/j.1750-3639.2008.00147.x
  3. Alafuzoff I, 2008, ACTA NEUROPATHOL, V115, P533, DOI 10.1007/s00401-008-0358-2
  4. Alafuzoff I, 2008, J NEUROPATH EXP NEUR, V67, P125, DOI 10.1097/nen.0b013e3181633526
  5. Alafuzoff I, 2006, J NEUROPATH EXP NEUR, V65, P740
  6. Alafuzoff I, 2009, ACTA NEUROPATHOL, V117, P635, DOI 10.1007/s00401-009-0523-2
  7. Alafuzoff I, 2009, ACTA NEUROPATHOL, V117, P309, DOI 10.1007/s00401-009-0485-4
  8. BANCHER C, 1989, BRAIN RES, V477, P90, DOI 10.1016/0006-8993(89)91396-6
  9. Botez G, 1999, ACTA NEUROPATHOL, V98, P251
  10. Braak H, 2006, ACTA NEUROPATHOL, V112, P389, DOI 10.1007/s00401-006-0127-z
  11. COHEN J, 1968, PSYCHOL BULL, V70, P213, DOI 10.1037/h0026256
  12. Crary JF, 2014, ACTA NEUROPATHOL, V128, P755, DOI 10.1007/s00401-014-1349-0
  13. Dickson DW, 1998, BRAIN PATHOL, V8, P339
  14. Dickson DW, 2002, J NEUROPATH EXP NEUR, V61, P935
  15. Dickson DW, 1999, J NEUROL, V246, pII6, DOI 10.1007/BF03161076
  16. Ferrer I, 2014, J NEUROPATH EXP NEUR, V73, P81, DOI 10.1097/NEN.0000000000000030
  17. HAUW JJ, 1994, NEUROLOGY, V44, P2015
  18. Ikeda C, 2016, BRAIN PATHOL, V26, P488, DOI 10.1111/bpa.12319
  19. Irwin DJ, 2016, ANN NEUROL, V79, P272, DOI 10.1002/ana.24559
  20. Irwin DJ, 2015, ACTA NEUROPATHOL, V129, P469, DOI 10.1007/s00401-014-1380-1
  21. Kovacs GG, 2015, NEUROPATH APPL NEURO, V41, P3, DOI 10.1111/nan.12208
  22. Kovacs GG, 2013, NEUROPATH APPL NEURO, V39, P166, DOI 10.1111/j.1365-2990.2012.01272.x
  23. Kovacs GG, 2017, J NEUROPATH EXP NEUR, V76, P270, DOI 10.1093/jnen/nlx007
  24. Kovacs GG, 2016, ACTA NEUROPATHOL, V131, P87, DOI 10.1007/s00401-015-1509-x
  25. Kovacs GG, 2013, ACTA NEUROPATHOL, V126, P365, DOI 10.1007/s00401-013-1157-y
  26. Lace G, 2012, DEMENT GERIATR COGN, V34, P15, DOI 10.1159/000341581
  27. LANDIS JR, 1977, BIOMETRICS, V33, P159, DOI 10.2307/2529310
  28. MAXWELL AE, 1977, BRIT J PSYCHIAT, V130, P79, DOI 10.1192/bjp.130.1.79
  29. McKee AC, 2016, ACTA NEUROPATHOL, V131, P75, DOI 10.1007/s00401-015-1515-z
  30. Montine TJ, 2016, ALZHEIMERS DEMENT, V12, P164, DOI 10.1016/j.jalz.2015.07.492
  31. Montine TJ, 2012, ACTA NEUROPATHOL, V123, P1, DOI 10.1007/s00401-011-0910-3
  32. Santpere G, 2009, BRAIN PATHOL, V19, P177, DOI 10.1111/j.1750-3639.2008.00173.x
  33. Schultz C, 2004, NEUROBIOL AGING, V25, P397, DOI 10.1016/S0197-4580(03)00113-1
  34. Thal DR, 2002, NEUROLOGY, V58, P1791
  35. Toledo JB, 2012, ACTA NEUROPATHOL, V124, P23, DOI 10.1007/s00401-012-0983-7

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - LIM/22