International high-risk clones of Klebsiella pneumoniae KPC-2/CC258 and Escherichia coli CTX-M-15/CC10 in urban lake waters

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Arquivos
art_NASCIMENTO_International_highrisk_clones_of_Klebsiella_pneumoniae_KPC2CC258_and_2017.PDF (413.56 KB)
Citações na Scopus
50
Tipo de produção
article
Data de publicação
2017
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE BV
Autores
NASCIMENTO, Tatiane
CANTAMESSA, Rodrigo
MELO, Luana
FERNANDES, Miriam R.
DROPA, Milena
SATO, Maria I. Z.
CERDEIRA, Louise
LINCOPAN, Nilton
Citação
SCIENCE OF THE TOTAL ENVIRONMENT, v.598, p.910-915, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The emergence of high-risk clones of multidrug-resistant (MDR) bacteria in aquatic environments has generated an important public health problem, creating an urgent need to strengthen surveillance. This study reports the occurrence of clinically significant MDR Enterobacteriaceae and non-fermentative bacteria carrying carbapenemases (KPC-2), extended-spectrum beta-lactamases (CTX-M) and plasmid-mediated quinolone resistance (PMQR) genes in urban lakes and reservoirs, in Southeastern Brazil. In this regard, the detection of hospital-associated lineages of KPC-2-producing Klebsiella pneumoniae belonging to the international clonal complex CC258 (STH) and CTX-M-15-producing Escherichia coli belonging to the international CC10 (ST617), in an urban lake, is reported for the first time. Whole genome sequencing (WGS) analysis of KPC-2-producing K. pneumoniae ST11 revealed that bla(KPC-2) gene was carried by an IncN plasmid on a Tn4401b element. This study support that aquatic environments with public access can act as reservoirs of clinically important MDR bacteria, constituting a potential risk to human and animal health. On the other hand, the detection of high-risk clones highlights the extra-hospital spread of clinically significant bacteria into urban aquatic environments.
Palavras-chave
Enterobacteriaceae, K pneumoniae ST11, E. coli ST617, CTX-M, PMQR, Aquatic environment
URI
https://observatorio.fm.usp.br/handle/OPI/21434
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Coleções
Artigos e Materiais de Revistas Científicas - FM/Outros
Artigos e Materiais de Revistas Científicas - ODS/03
Artigos e Materiais de Revistas Científicas - ODS/07