Inhaled ambient-level traffic-derived particulates decrease cardiac vagal influence and baroreflexes and increase arrhythmia in a rat model of metabolic syndrome

Imagem de Miniatura
Arquivos
art_CARLL_Inhaled_ambientlevel_trafficderived_particulates_decrease_cardiac_vagal_influence_2017.PDF (1.64 MB)
Citações na Scopus
27
Tipo de produção
article
Data de publicação
2017
Editora
BIOMED CENTRAL LTD
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
CARLL, Alex P.
COULL, Brent A.
DIAZ, Edgar A.
RAIMUNDO, Rodrigo D.
RICCI-VITOR, Ana Laura
PAPAPOSTOLOU, Vasileios
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
PARTICLE AND FIBRE TOXICOLOGY, v.14, article ID 16, 15p, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: Epidemiological studies have linked exposures to ambient fine particulate matter (PM2.5) and traffic with autonomic nervous system imbalance (ANS) and cardiac pathophysiology, especially in individuals with preexisting disease. It is unclear whether metabolic syndrome (MetS) increases susceptibility to the effects of PM2.5. We hypothesized that exposure to traffic-derived primary and secondary organic aerosols (P + SOA) at ambient levels would cause autonomic and cardiovascular dysfunction in rats exhibiting features of MetS. Male Sprague Dawley (SD) rats were fed a high-fructose diet (HFrD) to induce MetS, and exposed to P + SOA (20.4 +/- 0.9 mu g/m(3)) for 12 days with time-matched comparison to filtered-air (FA) exposed MetS rats; normal diet (ND) SD rats were separately exposed to FA or P + SOA (56.3 +/- 1.2 mu g/m(3)). Results: In MetS rats, P + SOA exposure decreased HRV, QTc, PR, and expiratory time overall (mean effect across the entirety of exposure), increased breathing rate overall, decreased baroreflex sensitivity (BRS) on three exposure days, and increased spontaneous atrioventricular (AV) block Mobitz Type II arrhythmia on exposure day 4 relative to FA-exposed animals receiving the same diet. Among ND rats, P + SOA decreased HRV only on day 1 and did not significantly alter BRS despite overall hypertensive responses relative to FA. Correlations between HRV, ECG, BRS, and breathing parameters suggested a role for autonomic imbalance in the pathophysiologic effects of P + SOA among MetS rats. Autonomic cardiovascular responses to P + SOA at ambient PM2.5 levels were pronounced among MetS rats and indicated blunted vagal influence over cardiovascular physiology. Conclusions: Results support epidemiologic findings that MetS increases susceptibility to the adverse cardiac effects of ambient-level PM2.5, potentially through ANS imbalance.
Palavras-chave
Particulate matter, Secondary organic aerosol, Baroreflex, Heart rate variability, Autonomic, Arrhythmia, Traffic, Respiratory, Cardiopulmonary
URI
https://observatorio.fm.usp.br/handle/OPI/21438
Referências
  1. Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
  2. Bartoli CR, 2009, ENVIRON HEALTH PERSP, V117, P361, DOI 10.1289/ehp.11573
  3. Brook RD, 2010, CIRCULATION, V121, P2331, DOI 10.1161/CIR.0b013e3181dbece1
  4. Carll AP, 2015, INHAL TOXICOL, V27, P100, DOI 10.3109/08958378.2014.995387
  5. Carll AP, 2013, TOXICOL SCI, V135, P425, DOI 10.1093/toxsci/kft155
  6. Carll AP, 2012, TOXICOL SCI, V128, P490, DOI 10.1093/toxsci/kfs162
  7. Carll AP, 2010, INHAL TOXICOL, V22, P355, DOI 10.3109/08958370903365692
  8. Carnevali L, 2014, FRONT PHYSIOL, V5, DOI 10.3389/fphys.2014.00118
  9. CASTELLANOS A, 1974, BRIT HEART J, V36, P487
  10. Chen JC, 2008, ENVIRON HEALTH PERSP, V116, P612, DOI 10.1289/ehp.10565
  11. Chuang HC, 2013, TOXICOL APPL PHARM, V266, P298, DOI 10.1016/j.taap.2012.11.006
  12. Cohen MA, 2002, J PHYSIOL-LONDON, V542, P669, DOI 10.1113/jphysiol.2002.017483
  13. Conklin DJ, 2011, ISSUES TOXICOL, V8, P301
  14. Cosselman KE, 2012, HYPERTENSION, V59, P943, DOI 10.1161/HYPERTENSIONAHA.111.186593
  15. Davoodi Gholamreza, 2010, Environmental Health and Preventive Medicine, V15, P217, DOI 10.1007/s12199-009-0130-9
  16. de Hartog JJ, 2009, ENVIRON HEALTH PERSP, V117, P105, DOI 10.1289/ehp.11062
  17. DELUNA AB, 1989, AM HEART J, V117, P151, DOI 10.1016/0002-8703(89)90670-4
  18. Devlin R B, 2003, Eur Respir J Suppl, V40, p76s
  19. Devlin RB, 2014, TOXICOL SCI, V140, P61, DOI 10.1093/toxsci/kfu063
  20. Diaz EA, 2013, AIR QUAL ATMOS HLTH, V6, P431, DOI 10.1007/s11869-012-0179-2
  21. Dick TE, 2014, PROG BRAIN RES, V209, P191, DOI 10.1016/B978-0-444-63274-6.00010-2
  22. Dresing TJ, 2001, CURR TREAT OPTION CA, V3, P291, DOI 10.1007/s11936-001-0091-9
  23. Epstein Andrew E, 2008, J Am Coll Cardiol, V51, pe1, DOI 10.1016/j.jacc.2008.02.032
  24. Farah V, 2007, AM J PHYSIOL-HEART C, V293, pH1083, DOI 10.1152/ajpheart.00106.2006
  25. Farraj AK, 2015, INHAL TOXICOL, V27, P564, DOI 10.3109/08958378.2015.1057884
  26. Farraj AK, 2011, AM J RESP CELL MOL, V44, P185, DOI 10.1165/rcmb.2009-0456OC
  27. Germano G, 1998, BLOOD PRESS MONIT, V3, P213
  28. Godleski JJ, 2011, INHAL TOXICOL, V23, P1, DOI 10.3109/08958378.2010.568019
  29. Han Y, 2011, J APPL PHYSIOL, V110, P646, DOI 10.1152/japplphysiol.00908.2010
  30. HATRIDGE J, 1989, J APPL PHYSIOL, V67, P2257
  31. Hazari MS, 2014, CARDIOVASC TOXICOL, V14, P52, DOI 10.1007/s12012-013-9228-9
  32. Hazari MS, 2011, ENVIRON HEALTH PERSP, V119, P951, DOI 10.1289/ehp.1003200
  33. Hemmingsen JG, 2015, PART FIBRE TOXICOL, V12, DOI 10.1186/s12989-015-0081-9
  34. Hotta H, 2009, AUTON NEUROSCI-BASIC, V151, P98, DOI 10.1016/j.autneu.2009.07.008
  35. Keuken MP, 2016, ATMOS ENVIRON, V132, P345, DOI 10.1016/j.atmosenv.2016.03.009
  36. KLEIGER RE, 1987, AM J CARDIOL, V59, P256, DOI 10.1016/0002-9149(87)90795-8
  37. La Rovere MT, 2001, CIRCULATION, V103, P2072
  38. Lamoureux DP, 2013, AIR QUAL ATMOS HLTH, V6, P407, DOI 10.1007/s11869-012-0177-4
  39. Lewin G, 2009, CIRCULATION, V119, P79, DOI 10.1161/CIRCULATIONAHA.108.786533
  40. MASSIE B, 1978, CIRCULATION, V58, P305
  41. MURAKAWA Y, 1992, AM J CARDIOL, V69, P339, DOI 10.1016/0002-9149(92)90230-V
  42. Papapostolou V, 2013, AIR QUAL ATMOS HLTH, V6, P419, DOI 10.1007/s11869-012-0178-3
  43. Papapostolou V, 2011, INHAL TOXICOL, V23, P853, DOI 10.3109/08958378.2011.619590
  44. Park SK, 2010, ENVIRON HEALTH PERSP, V118, P1406, DOI 10.1289/ehp.0901778
  45. Patel J, 2009, INDIAN J BIOCHEM BIO, V46, P66
  46. Peters A, 2015, PART FIBRE TOXICOL, V12, DOI 10.1186/s12989-015-0083-7
  47. Pham H, 2009, ENVIRON HEALTH PERSP, V117, P1448, DOI 10.1289/ehp.0900674
  48. Pinna GD, 2015, PHYSIOL MEAS, V36, P741, DOI 10.1088/0967-3334/36/4/741
  49. PIROLA FT, 1990, J AUTONOM NERV SYST, V31, P1, DOI 10.1016/0165-1838(90)90166-G
  50. Pope CA, 2015, CIRC RES, V116, P108, DOI 10.1161/CIRCRESAHA.116.305060
  51. Pope CA, 1999, AM HEART J, V138, P890, DOI 10.1016/S0002-8703(99)70014-1
  52. Rich DQ, 2012, ENVIRON HEALTH PERSP, V120, P1162, DOI 10.1289/ehp.1104262
  53. Rose BA, 2010, PHYSIOL REV, V90, P1507, DOI 10.1152/physrev.00054.2009
  54. Routledge HC, 2006, HEART, V92, P220, DOI 10.1136/hrt.2004.051672
  55. Schneider A, 2010, PART FIBRE TOXICOL, V7, DOI 10.1186/1743-8977-7-14
  56. Soliman EZ, 2014, HEART RHYTHM, V11, P93, DOI 10.1016/j.hrthm.2013.10.003
  57. Sun LX, 2013, PART FIBRE TOXICOL, V10, DOI 10.1186/1743-8977-10-43
  58. Tan Alex Y, 2013, Handb Clin Neurol, V117, P135, DOI 10.1016/B978-0-444-53491-0.00012-2
  59. Tartiere JM, 2008, AM HEART J, V155, P758, DOI 10.1016/j.ahj.2007.11.030
  60. Taylor JA, 2001, AM J PHYSIOL-HEART C, V280, pH2804
  61. Teng THK, 2014, J EPIDEMIOL COMMUN H, V68, P37, DOI 10.1136/jech-2013-203116
  62. Tilley DG, 2011, CIRC RES, V109, P217, DOI 10.1161/CIRCRESAHA.110.231225
  63. Tran LT, 2009, MOL CELL BIOCHEM, V332, P145, DOI 10.1007/s11010-009-0184-4
  64. UCHIDA Y, 1976, AM J PHYSIOL, V230, P1003
  65. Vanderlei FM, 2015, INT ARCH MED, V8, P1, DOI 10.3823/1799
  66. Vora R, 2014, PART FIBRE TOXICOL, V11, DOI 10.1186/s12989-014-0031-y
  67. Wagner JG, 2014, ENVIRON HEALTH PERSP, V122, P27, DOI 10.1289/ehp.1307085
  68. Wang F, 2010, ATMOS CHEM PHYS, V10, P2745
  69. Wellenius GA, 2004, TOXICOL SCI, V80, P367, DOI 10.1093/toxsci/kfh161
  70. Wiklund U, 2008, ANN NONINVAS ELECTRO, V13, P249, DOI 10.1111/j.1542-474X.2008.00228.x
  71. Wilker E, 2009, ENVIRON HEALTH PERSP, V117, P935, DOI 10.1289/ehp.0800279
  72. Zhang YY, 2011, ARCH INTERN MED, V171, P1727, DOI 10.1001/archinternmed.2011.433
  73. Zhao XY, 2014, HYPERTENSION, V63, P871, DOI 10.1161/HYPERTENSIONAHA.113.02588

Coleções
Artigos e Materiais de Revistas Científicas - FM/Outros
Artigos e Materiais de Revistas Científicas - ODS/03