Symptom dimensions are associated with age of onset and clinical course of obsessive-compulsive disorder

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author KICHUK, Stephen A.
TORRES, Albina R.
FONTENELLE, Leonardo F.
ROSARIO, Maria Conceicao
SHAVITT, Roseli G. FMUSP-HC
MIGUEL, Euripedes C. FMUSP-HC
PITTENGER, Christopher
BLOCH, Michael H.
dc.date.issued 2013
dc.identifier.citation PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v.44, p.233-239, 2013
dc.identifier.issn 0278-5846
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/2155
dc.description.abstract Meta-analysis of the heterogeneous symptoms of obsessive-compulsive disorder (OCD) has found a four-factor structure of symptom dimensions consisting of cleaning, forbidden thoughts, symmetry, and hoarding. Research into age of onset of symptom dimensions has yielded inconsistent results, and it is unknown whether symptoms along these dimensions differ in their clinical course. We assessed age of onset and clinical course of different OCD symptom dimensions in a large cohort of adult patients. Nine-hundred fifty-five subjects were assessed using the Dimensional Yale-Brown Obsessive-Compulsive Scale. For age of onset analysis, we tested across three methods of classification: (1) primary (more severe) symptom dimension (2) clinically significant symptoms within a dimension or (3) any symptoms within a dimension. Age of onset was defined as the earliest age of onset reported for any individual item within a symptom dimension. For analysis of different types of clinical course, we used chi-square tests to assess for differences between primary symptom dimensions. OCD symptoms in the symmetry dimension had an earlier age of onset than other OCD symptom dimensions. These findings remained significant across all three methods of classification and controlling for gender and comorbid tics. No significant differences were found between the other dimensions. Subjects with primary OCD symptoms in the forbidden thoughts dimension were more likely to report a waxing-and-waning course, whereas symmetry symptoms were less likely to be associated with a waxing-and-waning course. (C) 2013 Published by Elsevier Inc.
dc.description.sponsorship · Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2005/55628-8]
· Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [573974/2008-0]
· NIH/National Institute of Mental Health (NIMH)
· National Institutes of Health (NIH) [K23MH091240, K08MH081190]
· APIRE/Eli Lilly Psychiatric Research Fellowship
· AACAP/Eli Lilly Junior Investigator Award
· Trichotillomania Learning Center
· NARSAD
· Doris Duke Charitable Foundation
· National Center for Research Resources, a component of the National Institutes of Health (NIH) [UL1 RR024139]
· National Institutes of Health (NIH) roadmap for Medical Research
dc.language.iso eng
dc.publisher PERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartof Progress in Neuro-Psychopharmacology & Biological Psychiatry
dc.rights restrictedAccess
dc.subject.other ocd collaborative genetics; multicenter; predictors; phenotypes; features; children
dc.title Symptom dimensions are associated with age of onset and clinical course of obsessive-compulsive disorder
dc.type article
dc.rights.holder Copyright PERGAMON-ELSEVIER SCIENCE LTD
dc.description.group LIM/21
dc.identifier.doi 10.1016/j.pnpbp.2013.02.003
dc.identifier.pmid 23410525
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author SHAVITT, Roseli G.:HC:IPQ
hcfmusp.author MIGUEL, Euripedes C.:FM:MPS
hcfmusp.author.external · KICHUK, Stephen A.:Yale Univ, Dept Psychiat, New Haven, CT 06520 USA
· TORRES, Albina R.:Univ Estadual Paulista, Botucatu Med Sch, Dept Neurol Psychol & Psychiat, Botucatu, SP, Brazil
· FONTENELLE, Leonardo F.:Univ Fed Rio de Janeiro, Inst Psychiat, Anxiety & Depress Res Program, Rio De Janeiro, RJ, Brazil
· ROSARIO, Maria Conceicao:Univ Fed Sao Paulo, Sch Med, Dept Psychiat, Sao Paulo, SP, Brazil
· PITTENGER, Christopher:Yale Univ, Dept Psychiat, New Haven, CT 06520 USA; Yale Univ, Dept Psychol, New Haven, CT 06520 USA; Yale Univ, Ctr Child Study, New Haven, CT 06520 USA
· BLOCH, Michael H.:Yale Univ, Dept Psychol, New Haven, CT 06520 USA; Yale Univ, Ctr Child Study, New Haven, CT 06520 USA
hcfmusp.origem.id 2-s2.0-84876323992
hcfmusp.origem.id WOS:000320297400031
hcfmusp.publisher.city OXFORD
hcfmusp.publisher.country ENGLAND
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dc.description.index MEDLINE
hcfmusp.citation.scopus 19
hcfmusp.citation.wos 19
hcfmusp.affiliation.country Brasil
hcfmusp.affiliation.country Estados Unidos


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