High risk of heterosexual transmission of human T-cell lymphotropic virus type 1 infection in Brazil

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author PAIVA, Arthur FMUSP-HC
SMID, Jerusa
HAZIOT, Michel E. J.
ASSONE, Tatiane FMUSP-HC
PINHEIRO, Samara FMUSP-HC
FONSECA, Luiz A. M. FMUSP-HC
OLIVEIRA, Augusto C. Penalva de
CASSEB, Jorge FMUSP-HC
dc.date.issued 2017
dc.description.abstract Human T-cell lymphotropic virus type 1 is transmitted primarily either through sexual intercourse or from mother to child. The current study investigated sexual transmission and compared the HTLV-1 proviral load between seroconcordant and serodiscordant couples by examining both men and women among the index partners without using subjective criteria to establish the direction of sexual transmission. Between January 2013 and May 2015, 178 HTLV-1-positive patients had spouses, 107 of which had tested partners, thus increasing the initial sample size (46 men and 61 women). Individuals co-infected with HTLV-2 or human immunodeficiency virus were not included in the analysis. From among the included participants, 26 men and 26 women were paired with each other, resulting in 26 seroconcordant couples; 12 seroconcordant couples were formed from another four men and eight women. Forty-three serodiscordant couples were formed from 16 men and 27 women. The rate of seroconcordance was 46.9%. The HTLV-1 proviral load was compared between 19 and 37 seroconcordant and serodiscondant couples, respectively, and the concordant couples showed higher proviral loads (P = 0.03). There were no differences between the groups according to age, relationship length, having a mother or sibling with HTLV-1, race, ethnicity, nationality, education, history of blood transfusion, HAM/TSP, ALT, or hepatitis C virus status. In multivariate analysis, relationship time was shown associated with ocurrence of seroconcordance status. The apparent association between high circulating levels of provirus and seroconcordance rate among couples suggests that proviral loads contribute markedly to the risk of sexual transmission, regardless of gender index.
dc.description.group LIM/56
dc.description.group LIM/38
dc.description.index MEDLINE
dc.description.sponsorship · FAPESP [2012/23397-0]
· CNPq [234058/2014-5]
dc.identifier.citation JOURNAL OF MEDICAL VIROLOGY, v.89, n.7, p.1287-1294, 2017
dc.identifier.doi 10.1002/jmv.24745
dc.identifier.eissn 1096-9071
dc.identifier.issn 0146-6615
dc.identifier.pmid 27935065
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/21619
dc.language.iso eng
dc.publisher WILEY
dc.relation.ispartof Journal of Medical Virology
dc.rights restrictedAccess
dc.rights.holder Copyright WILEY
dc.subject Brazil; HTLV-1; proviral load; sexual transmission
dc.subject.other anti-tax antibody; htlv-i; sexual transmission; blood-donors; intrafamilial transmission; silent dissemination; leukemia-virus; family-members; proviral load; viral load
dc.title High risk of heterosexual transmission of human T-cell lymphotropic virus type 1 infection in Brazil
dc.type article
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author PAIVA, Arthur:IMT:
hcfmusp.author ASSONE, Tatiane:IMT:
hcfmusp.author PINHEIRO, Samara:HC:LIM/56
hcfmusp.author FONSECA, Luiz A. M.:HC:ICHC
hcfmusp.author CASSEB, Jorge:IMT:DVCIENT-83
hcfmusp.author.external · SMID, Jerusa:Inst Infect Dis Emilio Ribas IIER, Sao Paulo, SP, Brazil
· HAZIOT, Michel E. J.:Inst Infect Dis Emilio Ribas IIER, Sao Paulo, SP, Brazil
· OLIVEIRA, Augusto C. Penalva de:Inst Infect Dis Emilio Ribas IIER, Sao Paulo, SP, Brazil
hcfmusp.origem.id WOS:000405242000024
hcfmusp.publisher.city HOBOKEN
hcfmusp.publisher.country USA
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